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Amphocin is an antifungal drug that is administered intravenously. The drug is indicated for use in severe fungal infections and life-threatening fungal infections. How should Amphocin be taken?
1. What is Amphocin? What's the use?
Amphocin's active ingredient is Amphotericin B, which is given as an intravenous route.
Amphocin is used primarily to treat patients with severe, progressive and potentially life-threatening fungal infections. The drug is not used to treat non-invasive fungal diseases such as oral thrush, vaginal candidiasis, and esophageal candidiasis. The drug is indicated for the following patients:
Patients with severe life-threatening fungal infections; Prevention of the risk of fungal infections in some subjects with neutropenia, cancer, organ transplants with prolonged antibiotic use. Long-term treatment for people living with HIV because of the high risk of fungal infections. Amphocin's main active ingredient is Amphotericin B, which is an antifungal drug. Amphotericin B is an antifungal agent that binds to sterols (mainly ergosterol) in the fungal cell membrane, altering the membrane permeability, causing fungal killing.
The drug is insoluble in water but is formulated for intravenous infusion by complexing with bile salts deoxycholate, or complex with lipids to reduce toxicity. In addition, because the drug is poorly absorbed orally, it is often prepared in the form of an infusion.
2. How to use Amphocin?
How to use: The drug is prepared in the form of an intravenous infusion, so it should be prepared by medical staff and infused intravenously for the patient. In addition, the drug is also used by joint injection, spinal injection, pleural injection ... depending on the situation, there are appropriate routes of administration. When intravenous infusion should be given within 2 to 6 hours, avoid rapid infusion in less than 1 hour because of the potential for shock.
Dosage: Dosage depends on the severity of the disease, weight and comorbidities. Use time is usually once a day or every other day. To make sure it's safe to use the medicine, your doctor will test it on your skin first to make sure you're not allergic to it, and then proceed with the infusion.
Note: Amphotericin B for injection should not be used in doses greater than 1.5mg/kg. Care should be taken in dose selection to avoid accidental overdose, as overdose can lead to cardiac arrest or respiratory arrest with high potential for death, overdose in children can cause convulsions, cardiopulmonary arrest immediately after taking the drug. To make sure the product name and dosage need to be verified before use, keep a close eye on the medication.
3. Amphocin side effects
Along with the necessary effects in the treatment of disease, Amphocin medicine can cause some unwanted effects. Not all of these side effects are possible though. Here are some of the side effects that you may experience while taking Amphocin:
Some common side effects: Fever and chills, headache, increased or decreased frequency of urination, irregular heartbeat, cramps or muscle pain, nausea and vomiting, pain at the injection site, unusual tiredness or weakness; Some less common or rare side effects: Blurry or double vision, seizures, numbness, tingling, pain or weakness in the hands or feet, trouble breathing, trouble breathing, wheezing or tightness in the chest, itching tingling, pain or weakness... Tell your doctor if the following side effects persist or make you uncomfortable: Diarrhea, headache, indigestion, loss of appetite, nausea or vomiting , stomachache; with spinal injection causes back pain, leg pain, neck pain, dizziness or lightheadedness... In addition to the above side effects, when using the drug you can also occur other side effects. It is necessary to notify or seek medical attention for advice and care when serious or prolonged side effects occur.
4. Notes when taking Amphocin
Do not use this medicine with patients with a history of hypersensitivity to any of the ingredients contained in the drug. Use caution in patients with impaired renal function because the drug is nephrotoxic.
Before taking the drug, it is necessary to inform the doctor about the allergic condition, the accompanying diseases. The use of drugs for children has not seen a higher risk of harm than adults, but it should be considered when used, elderly people may have impaired kidney function, so choose the appropriate dose. Talk to your doctor so you can weigh the benefits and risks of administering the drug to the patient.
Medication should be administered in a hospital where emergency conditions are available. Patients should be closely monitored while taking the drug, especially in the early stages. Drug-related adverse events may occur during the first infusion, 1 to 3 hours after the first infusion. In the beginning, liver and kidney function should also be monitored, blood count by testing twice a week.
This medicine should only be used under the direction of a doctor and only when absolutely necessary in a life-threatening situation.
Drug interactions: The use of Amphocin with other drugs can cause drug interactions. Some drugs that cause interactions with this drug include:
Nephrotoxic drugs (aminoglycosides, capreomycin, colistin, cisplatin, cyclosporine, methoxyflurane, pentamidine, polymyxin B, vancomycin) must be avoided in combination with amphotericin B. blood potassium (cardiac glycosides, tubocurarin...) if used concurrently with amphotericin B will increase cardiotoxicity due to cardiac glycosides and increase the muscle relaxant effect of muscle relaxants. Other antifungals: Flucytosin and amphotericin B have a synergistic inhibitory effect on some fungi, but co-administration may increase flucytosin toxicity by increasing local cellular absorption and/or decreasing its excretion. through the kidney. If the two drugs are used concurrently in HIV-infected individuals, serum flucytosin levels and blood cell counts should be measured. Zidovudine: Co-administration of these two drugs in animals for 30 days has been shown to increase myelotoxicity and nephrotoxicity. Although not known in humans, when combining these two drugs, caution should be exercised, closely monitoring renal function and hematology. Anticancer drugs (such as mechlorethamine) may increase nephrotoxicity, bronchospasm, and lower blood pressure in patients receiving these two drugs concurrently. Corticosteroids can increase the loss of potassium in the body from amphotericin B. The two drugs should not normally be combined, unless needed to treat the side effects of amphotericin B. Here's some information. About the drug Amphocin, the drug is used under the doctor's prescription when absolutely necessary. You should ask your doctor about the possible risks so that you can self-monitor while taking the medication.
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Reference source: drugs.com
