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Amnox drug with the main ingredient is Clopidogrel, known quite popularly with the main effect of preventing and treating cardiovascular disease. Learning about information, ingredients and usage helps users to use the drug effectively.
1. What is Amnox?
Amnox drug belongs to the group of cardiovascular drugs, manufactured and registered at AMN Life Science Pvt, Ltd - INDIA, with SKU: VN-16938-13.
Amnox drug is prepared in the form of film-coated tablets, packed in the form of a box of 3 blisters x 10 tablets, with the main ingredient being Clopidogrel 75mg and excipients just enough in 1 tablet (including: Microcrystalline Cellulose, Maize Starch, Anhydrous Colloidal Silica, Povidon, Purified Talc, Sodium Starch Glycollat, Croscarmellose Sodium, Ready mix, Filmcoat Erythrosin colour).
2. What are the uses of Amnox?
Amnox is used in the following cases:
Primary prevention of thromboembolic disorders in patients at risk of myocardial infarction, stroke and peripheral artery disease. Control, secondary prevention in patients with atherosclerotic plaque with recent myocardial infarction, recent stroke, or established peripheral arterial disease. Treatment of patients with acute coronary symptoms (a syndrome with unstable angina/non-Q-wave myocardial infarction), including patients who have undergone coronary intervention (with implantation of coronary artery disease). stent or no stent) or the patient has recovered.
3. Usage and dosage of Amnox
3.1. How to take Amnox is taken orally. Clopidogrel is not an additive when taken with food, so Amnox can be taken with or after meals.
3.2 Dosage For different conditions of patients, the dose is applied differently, patients should take the drug according to the instructions on the listing sheet or according to the doctor's prescription or refer to the following dosage:
For patients with a history of atherosclerosis, the dose is 1 tablet Amnox 75mg/day. Prophylactic dose to prevent diseases: myocardial infarction, stroke and peripheral artery disease is: 1 tablet Amnox 75mg/day. Treatment in acute coronary syndrome: The starting dose is 300mg (4 Amnox 75mg tablets), a single dose and the maintenance dose is Amnox 75mg/day. For the elderly and patients with renal impairment, no dose adjustment is required. 3.3. What to do in the event of an Amnox overdose An overdose of Clopidogrel can lead to prolonged bleeding time and cause bleeding complications. There are experimental data on lethal doses of 1500 or 2000 mg/kg in rats.
If a patient with an overdose of Amnox develops symptoms of acute toxicity such as vomiting, shortness of breath, exhaustion, and gastrointestinal bleeding that have been reported, they should be treated as soon as possible, using platelet transfusions can reverses the pharmacological effects of clopidogrel.
4. Contraindications to taking Amnox
Amnox drug is not used in the following cases:
Patients with hypersensitivity, history of allergy to Clopidogrel or any ingredient of the drug. Patients with bleeding diseases such as intracranial hemorrhage, gastrointestinal ulcers. Severe liver failure.
5. Amnox drug interactions
Amnox drug when used in combination with some of the following drugs may cause drug interactions such as:
When clopidogrel is combined with Aspirin, a pharmacodynamic interaction between these two drugs may occur and lead to an increased risk of bleeding. blood. Therefore, patients should be cautious when co-administering Clopidogrel with Aspirin. Co-administration of Clopidogrel with Heparin may result in an increased risk of bleeding. Therefore, caution should be exercised when co-administering Clopidogrel with Heparin. Concomitant use of Clopidogrel with Warfarin should be used with caution because of an increased risk of bleeding. Caution should be exercised when co-administration of non-steroidal anti-inflammatory drugs (NSAIDs) with clopidogrel may increase the potential for gastrointestinal bleeding, which has been reported in studies in healthy volunteers using naproxen, using naproxen. Concomitant use of naproxen and clopidogrel. Drugs Metabolized by the Cytochrome P450 System with Clopidogrel: At high concentrations in vitro, Clopidogrel inhibited Cytochrome P450 (2C9). It may therefore affect the metabolism of Tamoxifen, Phenytoin, Tolbutamide, Fluvastatin, Warfarin, Torsemid and many other non-steroidal anti-inflammatory agents, but there are no data on the severity of these interactions. Concomitant administration of Clopidogrel with an inhibitor of CYP2C19 enzyme activity may result in decreased concentrations of the active metabolite Clopidogrel. Therefore, caution should be exercised when co-administering CYP2C19 inhibitors including Esomeprazole, Omeprazole, Fluvoxamine, Fluoxetine, Fluconazole, Moclobemide, Voriconazole, Ticlopidine, Ciprofloxacin, Cimetidine, Carbamazepine, Oxcarbazepine and Chloramphenicol. To ensure safety when using the drug, the patient should inform the doctor, the pharmacist treating all the current drugs and other medical conditions.
6. Side effects when using Amnox
Amnox drug is generally well absorbed, but in the process of using Amnox drug, patients may encounter some unwanted effects such as:
Common:
Skin allergies such as: Erythema, itching. Gastrointestinal disorders such as: Diarrhea, abdominal pain, indigestion and nausea. Uncommon:
Chest tightness, nosebleeds. Rare:
Gastrointestinal bleeding, gastric ulcer Severe neutropenia or agranulocytosis, thrombocytopenia, thrombocytopenic purpura, aplastic anemia. Kidney disease such as nephritic syndrome Loss of taste Acute arthritis Intracerebral and ocular haemorrhage.
7. Precautions when using Amnox
Patients should note some of the following before using Amnox.
Use caution when using Clopidogrel in patients with bleeding due to trauma, surgery or other pathologies. In case the patient is about to undergo surgery, clopidogrel must be discontinued 5 days before surgery. Clopidogrel should be used with caution in patients with bleeding-prone lesions (eg, ulcers). Caution should be exercised when using Amnox drugs that can cause similar damage to patients taking Clopidogrel. Clopidogrel should be used with caution in patients with hepatic impairment who have changes in metabolism such as poor metabolism due to CYP2C19. There is limited experience with clopidogrel in patients with severe renal impairment. Therefore, extreme caution should be exercised when clopidogrel is used in these patients. Pregnancy using Clopidogrel: There are no adequate studies on the use of Amnox in pregnant women. Therefore, Amnox should only be used during pregnancy when clearly needed. Lactation: There are no data on whether clopidogrel is excreted in human milk. Since many Amnox drugs are excreted in human milk, caution should be exercised when administering the drug to a nursing woman. Amnox does not affect the ability to drive and use machines. Amnox is only available on prescription from a doctor or pharmacist. Patients are not allowed to arbitrarily buy Amnox medicine to self-treat at home. If there are any side effects during the use of the drug, notify your doctor immediately for more information and timely treatment.
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