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The drug ambixol 15mg/5ml has the main ingredient Ambroxol hydrochloride. Effective in the treatment of bronchial asthma, exacerbation of chronic bronchitis, acute bronchitis. On the market today, there is a lot of information about the drug product ambixol 15mg/5ml, but it is still incomplete. To better understand what ambixol is, what are the uses of ambixol 15mg/5ml, let's learn more in the article below.
1. What is ambixol 15mg/5ml?
Ambixol 15mg/5ml Syrup is an OTC medicine used in the treatment of bronchial asthma and acute bronchitis as well as chronic bronchitis.
Dosage form of the drug ambixol 15mg/5ml: The main dosage form is: Each 5ml of syrup contains Ambroxol hydrochloride 15mg Concentration, content: 15mg Registration number: VN-20667-17 Packing: Box of 1 bottle of 100ml Manufacturer: Sopharma AD Distributor: DP TW Codupha Joint Stock Company Ingredients of Ambixol 15mg/5ml Syrup: The main ingredient is Ambroxol Hydrochlorid 15mg/5ml
Other excipients: Sorbitol 35g, Methyl Parahydroxybenzoate 0.1g, Propyl Parahydroxybenzoate 0.02g, Glycerol 10g, Propylene Glycol 28, Saccharin Sodium 0.02g, Citric Acid Monohydrate 0.1g, Raspberry flavoring 0.03g and Purified water just enough 100 ml.
1.1. Pharmacodynamics of ambixol 15mg/5ml:
Ambroxol is a metabolite of Bromhexin and a mucolytic agent that acts on the gel phase of mucus by cleaving the disulfure bridge. of glycoproteins and thus facilitate expectoration.
Ambroxol is a derivative of mucolytics and bromhexine. The drug stimulates the mucous glands to secrete secretions, and cuts off the glycoprotein acid system in the mucus, making the sputum less sticky. Ambroxol stimulates the action of the cilia and increases the cleansing ability of the cilia, making it easier to spit out thin mucus.
1.2. Pharmacokinetics of ambixol 15mg/5ml:
Ambroxol is well absorbed from the gastrointestinal tract and reaches maximum plasma concentrations approximately 2 hours after oral administration. Bioavailability of the drug is about 70%. Drugs with a high volume of distribution indicate that there will be significant extravascular diffusion.
The half-life is about 7.5 hours. The drug is mainly excreted in the urine with two major metabolites in the form of glucuronic conjugates. Elimination of the active substance and metabolites mainly takes place in the kidneys.
2. What are the uses of ambixol 15mg/5ml?
Ambroxol is a metabolite of Bromhexin, it has the same effect and effect as Bromhexin. Ambroxol is considered to have expectorant and mucolytic effects but has not been fully proven. Ambixol 15mg/5ml Syrup is indicated for the treatment of acute and chronic diseases of the respiratory tract associated with abnormal mucus secretion and impaired mucus transport, such as bronchial asthma and inflammation. bronchi, exacerbation of chronic bronchitis.
Some literature reports that ambroxol improves symptoms and reduces the number of exacerbations in bronchitis.
Recent literature suggests that the drug is effective in patients with mild and moderate obstructive pulmonary disease, but has no clear benefit for those with severe obstructive pulmonary disease.
Nebulized ambroxol also works well for patients with alveolar proteinosis, who refuse to wash the bronchi.
3. Contraindications of ambixol 15mg/5ml
Ambixol 15mg/5ml syrup should not be used in the following cases:
Hypersensitivity to any ingredient in the formula. Gastric ulcers.
4. Side effects of the drug ambixol 15mg/5ml
Side effects on the immune system: rare allergic reactions and hypersensitivity with symptoms such as swelling of the face, increased body temperature, tremors,... Side effects on the respiratory system such as runny nose. Gastrointestinal side effects: the most common is diarrhea. Some less common side effects include: nausea, vomiting, upset stomach, constipation,... Side effects on the skin and subcutaneous tissue: redness and itching of the skin, more rarely Dubin's syndrome- Johnson, Lyell's syndrome,... Urinary side effects such as urinary retention,... If you see any of the above symptoms or any other symptoms during the course of taking the drug, notify us. Immediately consult your doctor or pharmacist for assistance.
5. Drug interactions
Antibiotics such as Cefuroxim, Erythromycin, Doxycycline, Amoxicillin, ... used together with Ambixol 15mg/5ml syrup can increase the concentration and absorption of antibiotics.
Do not use syrup Ambixol 100ml at the same time with drugs that inhibit the cough center.
To ensure safety and effectiveness, tell your doctor about all medicines, health foods you are taking and other diseases you have.
6. How to use ambixol 15mg/5ml effectively
Taking medicine should not depend on meals. However, it should be taken after meals with the appropriate dose in the enclosed graduated cup.
Children under 2 years old: 2.5 ml/time and 2 times/day (corresponding to 15 mg ambroxol hydrochloride/day).
Children from 2 to 5 years old: 2.5 ml/time, 3 times/day (corresponding to 22.5 mg ambroxol hydrochloride/day).
Children from 6 to 12 years old: 5 ml/time, 2-3 times/day (corresponding to 30 - 45 mg ambroxol hydrochloride/day).
Adults and adolescents over 12 years old:
+ In the first 2-3 days: 10 ml/time and 3 times/day (corresponding to 90 mg ambroxol hydrochloride/day).
+ Then: 10ml/time and 2 times/day (corresponding to 60mg ambroxol hydrochloride/day).
At the dose for adults and adolescents over 12 years old, to increase the effectiveness, can use 20ml / time, 2 times / day (corresponding to 120 mg ambroxol hydrochloride / day).
According to the medical guidelines, the duration of the basic drug should not be limited. However, patients should not use it for more than 4 to 5 days without medical advice.
6.1. Treatment of overdose when taking ambixol 15mg/5ml There are no specific reports of symptoms of drug overdose. If you experience an overdose, you should immediately notify your doctor or go to the nearest medical facility to receive appropriate adjustment.
6.2. How to handle a missed dose of ambixol 15mg/5ml Use the dose as soon as you remember.
+ Skip the missed dose if it is almost time for the next dose, take the next dose as scheduled.
+ Do not take double the prescribed dose.
7. Be careful when using ambixol 15mg/5ml
With caution when used for patients with liver damage and kidney failure, the dose is reduced by 1/2 compared to the adult dose. Products containing Sorbitol should be used with caution in people with fructose intolerance and may cause a mild laxative effect. The product contains Methyl Parahydroxybenzoate, Propyl Parahydroxybenzoate (paraben compound) which may cause allergic reactions (possibly delayed). Concomitant use of Ambroxol and antibiotics (Amoxicillin, Cefuroxim, Erythromycin, Doxycycline) leads to an increase in antibiotic concentrations in lung tissue. Ambroxol should not be used concomitantly with cough suppressants. Animal studies have also shown that the drug is not teratogenic, but due to the lack of data in humans, caution should be exercised to avoid its use during pregnancy. If you are pregnant, ask your doctor or pharmacist for advice and answers before taking this medicine. This medicine should not be used during lactation as it is excreted in breast milk.
8. Notes when using the drug and how to store ambixol 15mg/5ml
8.1. When used in pregnancy and lactation Pregnant women:
+ Animal studies have shown no teratogenic effects.
+ There are no adequate human studies so avoid taking this medicine during pregnancy.
Lactating mothers: The drug is excreted in breast milk. This medicine should not be used while breastfeeding.
Precautions for taking Ambixol 15mg/5ml syrup during pregnancy Animal studies have shown that the drug is not teratogenic. Due to the lack of data in humans, caution should be exercised to avoid this drug during pregnancy.
Look up the US Food and Drug Administration (FDA) classification of drugs for use in pregnancy below:
A = No risk;
B = No risk in some studies
C = Possible risk;
D = There is evidence of risk;
X = Contraindications;
N = Still unknown.
Note to use Ambixol 15mg/5ml syrup when breastfeeding Do not use while breastfeeding. Note to use Ambixol 15mg/5ml syrup for the elderly Use caution with the elderly because the sensitivity to the drug in this subject may be greater than that of normal adults. Notes on diet when taking Ambixol 15mg/5ml syrup Read carefully the dietary notes on the instruction sheet. Care should be taken in taking the drug. Carefully read the instructions in the container, or your doctor's instructions. 8.2. People driving and operating machines should not affect the ability to drive and use machines. 8.3. Other special precautions Use caution when used in people with liver damage and kidney failure. The product contains Sorbitol and should be used with caution for people with fructose intolerance which may cause a mild laxative effect. The product contains Propyl parahydroxybenzoate and Methyl parahydroxybenzoate (Paraben compound) risk of allergic reactions (may appear delayed). 8.4. Storage conditions Temperature below 30 degrees C. Protect from light. Keep out of sight and reach of children. Do not use after the expiry date printed on the package.
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