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Alvotinib has the main ingredient Imatinib, which is made in the form of film-coated tablets. It is indicated for the treatment of leukemia, Hypereosinophilic syndrome and inoperable gastrointestinal malignancies.1. What is Alvotinib 100mg?
Alvotinib 100mg is a product manufactured in the Republic of Cyprus by Remedica Ltd Pharmaceuticals. Alvotinib 100mg drug has the main ingredient Imatinib and excipients just enough 1 tablet.
Alvotinib 100mg is made in the form of film-coated tablets.
2. Indications and contraindications of Alvotinib 100mg
2.1. Indications of Alvotinib 100mg Alvotinib 100mg is indicated in the following cases:
People with chronic myeloid leukemia (CML). People with acute lymphoblastic leukemia, Philadelphia chromosome (Ph-positive ALL). Myelodysplastic/myelodysplasia (MDS/MPD). Hypereosinophilic syndrome or chronic eosinophilic leukemia Treatment of unresectable metastatic protuberans dermatofibrosarcoma. Indicated for patients with gastrointestinal malignancies that cannot be resected, metastatic (GIST). 2.2. Contraindications of the drug Alvotinib 100mg Contraindications of the drug Alvotinib 100mg with any person with hypersensitivity to any ingredient of the drug.
3. Usage - Dosage of Alvotinib 100mg
3.1. How to take Alvotinib 100mg is made in the form of film-coated tablets that should be taken orally. Patients should take the drug with food, along with plenty of water.
3.2. Dosage Adults:
Patients with chronic myeloid leukemia: 400-800 mg/day. Patients with chronic myeloid leukemia in the acute stage and the flare-up: Dosage 600-800 mg/day, divided into 1-2 times. Patients with acute lymphoblastic leukemia, Philadelphia chromosome: 600 mg/day. Patients with Myelodysplastic disease / myelosuppression: Dosage 400 mg/day. Patients with SM: Dosage 400 mg/day; SM combined with eosinophilia: Dosage is 100 mg/day, or may be increased to 400 mg/day if well tolerated and inadequate response to therapy. Gastrointestinal malignancies: Dosage 400-600 mg/day, adjuvant treatment after surgical resection of GIST: Dosage is 400 mg/day. Fibrodermoid sarcoma (DFSP): 800 mg/day. Children:
Chronic myeloid leukemia: The dose is 340 mg/m2/day (be careful not to exceed the total dose of 600 mg/day). It should be noted: The above drug dosage is for reference only, patients need to take the drug exactly as prescribed by the doctor or pharmacist who has advised and prescribed it.
4. Notes when using Alvotinib 100mg
During the use of Alvotinib 100mg, patients need to pay attention to the following:
People with severe liver failure should carefully weigh the benefits and risks before appointing the drug. In addition, a complete blood count and liver enzyme tests should be performed. Patients should take the drug with Alvotinib 100mg with a large glass of water to minimize gastrointestinal irritation. Alvotinib 100mg drug has the potential to cause fluid retention complications. Therefore, the elderly, people with a history of heart failure need to weigh themselves regularly to monitor and detect abnormalities early. Special attention is required, as bleeding may occur. Cancer patients need to check the blood count regularly, if there is any abnormality, the dose can be stopped or reduced. Pregnancy and breast-feeding: Both of these cases should not take Alvotinib 100mg. If Alvotinib 100mg must be used during pregnancy, the benefits and risks should be weighed. During lactation, if the drug must be used, breast-feeding should be discontinued. Using Alvotinib 100mg for drivers and operating machines: Alvotinib 100mg can cause headache, nausea, fever,... Therefore, caution should be exercised when driving and operating machinery.
5. Side effects of Alvotinib 100mg
During the use of Alvotinib 100mg, patients may experience some of the following side effects:
Rash; difficulty breathing, swelling of the face, lips and tongue. Fever, chills, body aches; Bruising, unusual bleeding Body edema, rapid weight gain, feeling short of breath Black/clay or bloody stools Nausea, upper abdominal pain, loss of appetite, jaundice Coughing up blood Less urine, urinary retention, blood in the urine, dark urine; Numbness, stinging sensation around the mouth; Back pain, muscle weakness, overactive reflexes; Arrhythmia , weak pulse , feeling short of breath , confusion , fainting Skin allergy , redness , hives . In addition, patients also experience other side effects but not listed above. Therefore, if the patient shows unusual symptoms, allergies, it is necessary to immediately notify the doctor or go to a medical facility for timely examination and treatment.
6. Alvotinib 100mg . drug interactions
During the use of Alvotinib 100mg, the following interactions may occur if the patient takes the drug simultaneously:
Some drugs can increase the concentration of imatinib in the blood plasma: itraconazole, ketoconazole, erythromycin, clarithromycin. .. Drugs that can reduce plasma concentrations of imatinib: phenytoin, dexamethasone, carbamazepicine, rifampicine, phenobarbital. Plasma concentrations may be altered by imatinib simvastatin, paracetamol, ceclosporin;
7. Treatment of missed dose, overdose of Alvotinib 100mg
If you forget a dose of Alvotinib 100mg, take that dose as soon as you remember. However, if it is too long, skip the missed dose, take the next dose as usual, do not take a double dose to make up for the missed dose.
The overdose of the drug can cause dangerous complications affecting health. Therefore, if the drug overdose and abnormal symptoms appear, the patient should stop using and notify the doctor for timely treatment.
Patients need to store Alvotinib 100mg at a temperature below 30°C, in the original packaging and avoid direct light. Keep medicine out of reach of children and household pets.
In summary, Alvotinib has the main ingredient Imatinib, which is made in the form of film-coated tablets. It is indicated for the treatment of leukemia, Hypereosinophilic syndrome and inoperable gastrointestinal malignancies.
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