Uses of Afinitor 2.5 mg

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1. What are the effects of Afinitor 2.5 mg?

Afinitor 2.5 mg is used in the following cases:
In combination with exemestane for postmenopausal women with hormone receptor-positive (+), HER2/neu (-) breast cancer, after recurrence or progression without symptomatic visceral metastasis & prior treatment with a non-steroidal aromatase inhibitor. Adult patients with advanced stage neuroendocrine tumors of pancreatic origin, well or moderately differentiated, inoperable or metastatic. Treatment of advanced renal cell carcinoma with disease progression during or after VEGF-targeted therapy. Afinitor 2.5 mg is not used for patients with hypersensitivity, history of allergy to Everolimus or any of the ingredients in the drug. The patient is allergic to Rapamycin derivatives.

2. Dosage - How to take Afinitor 2.5 mg

2.1. How to use Afinitor is taken once a day at a certain time, can be taken with or without food.
Patients should swallow the Afinitor tablet whole with 1 glass of water, do not chew or crush the tablet.
In case the patient cannot swallow the whole tablet, the Afinitor tablet can be completely dissolved in 1 glass of water about 30ml by gently stirring the tablet until it is completely dissolved and used immediately after dissolving the drug. The patient should rinse the glass with a small amount of water and drink it all to ensure the dose.
2.2. Dosage The dosage of Afinitor 2.5mg is as follows:
Adults: Use the recommended dose of 10mg Everolimus tablets, taken once a day. Continue treatment with Everolimus until clinical benefit is observed or unacceptable toxicity occurs. In cases of severe or unacceptable adverse drug reactions, a temporary reduction of Everolimus dose of approximately 50% may be required. Children: Everolimus is not recommended for children with cancer. Elderly patients > 65 years: No dose adjustment of Everolimus is required. Patients with renal impairment: No dose adjustment of Everolimus is required. Hepatic impairment: Mild hepatic impairment, the recommended dose is 7.5mg Everolimus/day. Moderate hepatic impairment The recommended dose is 5 mg/day and can be reduced to 2.5 mg Everolimus if well tolerated. In severe liver failure, the use of Everolimus is not recommended. If the potential benefit outweighs the risk, a dose not to exceed 2.5 mg Everolimus/day can be used.

3. Drug Interactions Afinitor 2.5 mg

Combination of Afinitor 2.5 mg with some of the following drugs may cause drug interactions such as:
Combination of Everolimus with strong inhibitors of CYP3A4/PgP such as Ritonavir, Ketoconazole, Itraconazole, Clarithromycin, Telithromycin ,.... Combining Everolimus with Live Vaccines. Grapefruit and grapefruit juice, Seville oranges, star fruit, food affect CYP3A4/PgP. Cautiously combine Everolimus with moderate inhibitors of CYP3A4/PgP such as: Verapamine, Erythromycin, Ciclosporin, Amprenavir, Fluconazole, Diltiazem, Aprepitant,... Caution should be exercised in combining Everolimus with strong inducers of CYP3A4/PgP such as: Rifabutin, Rifampicin, St John's Wort, Corticosteroids, antiviral drugs, anticonvulsants,... The above are not all possible drug interactions when using Afinitor 2.5 mg in combination. To ensure safety, the patient should list to the doctor all the medicines or health-protective drugs that are being used by the medical professional to avoid unwanted interactions.

4. Side effects when taking Afinitor 2.5 mg

During the use of Afinitor 2.5 mg, patients may experience some side effects as follows:
Common:
Infection Anemia, thrombocytopenia, neutropenia, lymphocytopenia, decreased white blood cells. Decreased appetite, hyperglycemia, hypercholesterolemia, hypertriglyceridemia, hypophosphataemia, hyperlipidemia, hypokalemia, dehydration, diabetes mellitus. Insomnia... Uncommon:
Noncardiac chest pain Amenorrhoea Frequent urination, acute renal failure Hemoptysis, pulmonary embolism Deep vein thrombosis Total platelet count anaphylaxis Hypersensitivity reactions Rare:
Any Simple red blood cell production Acute respiratory distress syndrome Angioedema Slow wound healing

5. Precautions when using Afinitor 2.5 mg

Patients should carefully refer to the notes and cautions in the instruction sheet for Afinitor 2.5 mg. In addition, you can refer to some notes when using Afinitor 2.5 mg as follows:
In case of women of childbearing potential: It is recommended that women of childbearing potential use a highly effective method of contraception during while taking Everolimus and up to 8 weeks after ending treatment with Everolimus. There have been no reports of Everolimus causing infertility in male or female patients. However, there are data showing menstrual irregularity, secondary amenorrhea, and an imbalance of luteal and follicle-stimulating hormone. Therefore, the use of Afinitor medicine can reduce fertility in men and women. In the case of pregnant women: There are not enough data on the safety and efficacy of Afinitor in pregnant women, there are data on fetotoxicity in animals but unknown in humans. Therefore, Afinitor should not be used during pregnancy, only when the potential benefits outweigh the risks. Lactation: It has not been reported whether Everolimus is excreted in human milk. However, in clinical studies used in rats, Everolimus was found to be excreted in human milk. Therefore, Afinitor should not be used while breastfeeding. Cases of overdose of Afinitor are limited. In animal studies, Everolimus showed low-grade toxicity, with no fatal or severe toxicity observed in mice or rats at doses limited to 2000 mg/kg. Single doses of approximately 70 mg have been administered with tolerable acute tolerability. In this case, general supportive measures should be taken in all cases of Everolimus overdose. Hopefully with the useful information below, patients can have more useful information about the Afinitor drug line. Patients should always strictly follow the instructions for taking Afinitor medication by their doctor or pharmacist to ensure safety and effectiveness.

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