This is an automatically translated article.
Systemic lupus erythematosus is a fairly common autoimmune disease, mainly caused by the body's abnormal immune response leading to the immune system fighting against the body's own organs.1. What is an anti-Sm test?
The anti-Sm antibody is a ribonucleoprotein-bound antibody that plays an important role in clinical practice when directed against the 7 nuclear proteins of the cell, this complex is involved in mRNA translation and present. present in 5 to 30% of patients with systemic lupus erythematosus.
Because of the specificity of the anti-Sm antibody, the anti-Sm test is influential in the serological criteria for the diagnosis of systemic lupus erythematosus.
The anti-Sm test is an ELISA based automated in vitro test system for the determination of the amount of IgG antibodies against the Sm protein in the serum or plasma of a patient.
2. Significance of anti-Sm test in the diagnosis of Lupus
Mẫu xét nghiệm anti-Sm trong chẩn đoán Lupus
The highly specific anti-Sm test is found in most cases of systemic lupus erythematosus. Although the positive rate in cases is only about 20% of those infected. But anti-Sm donors are rarely found in other immunological diseases and only in 1% of healthy people. Therefore, testing and quantification of anti-Sm are useful in the definitive diagnosis of systemic lupus erythematosus.
However, unlike anti-dsDNA, anti-Sm is not directly correlated with the presence of the kidney-damaging form of lupus and the scientific evidence also suggests that anti-Sm is not associated with exacerbations. of active lupus.
3. Diagnosis of systemic lupus erythematosus is based on what factors?
Viêm màng phổi là một trong các yếu tố chẩn đoán bệnh Lupus ban đỏ hệ thống
According to the American Rheumatology Society's 1997 SLE diagnostic criteria, systemic lupus erythematosus is diagnosed based on the following factors:
Cheek rash: Butterfly-shaped rash on the nose and cheeks Disc-shaped rash: Erythema Elevated, well-defined margin with unreliably adherent keratosis, follicular thickening of hair follicles, with skin atrophy Light sensitivity Oral ulcers Arthritis : Two or more peripheral joints swollen, painful, effusion Serositis: Pleurisy, pleural effusion, pericarditis, pericardial effusion Renal disorders: Cellular deposits, proteinuria over 500 mg/day Central nervous system disorders: Seizures or episodes of psychotic absence Hematologic disorders: Hemolytic anemia with reticulocytosis, leukopenia and thrombocytopenia. Immune disorders: In addition to anti-Sm (+), there are also LE (+) cells, anti-DNA (+) Antinuclear antibodies: Ds DNA, SSA and SSB If there are more than 4 diagnostic criteria, the patient will was diagnosed with systemic lupus erythematosus.
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