Pulmonary fibrosis in premature infants: Symptoms, diagnosis and treatment

This is an automatically translated article.

The article was professionally consulted by Specialist Doctor I Nguyen Thi My Linh - Neonatologist - Department of Pediatrics - Neonatology - Vinmec Danang International General Hospital. Specialist Doctor I Nguyen Thi My Linh has 12 years of experience in diagnosing and treating pediatric diseases.
Pulmonary fibrosis in premature babies is a disease that damages the lungs, which can lead to dangerous complications such as heart failure, respiratory failure. The disease affects the health and development of children.

1. What is pulmonary fibrosis in premature infants?

Pulmonary fibrosis is a lung disease that occurs when lung tissue is damaged and scarred. Thick and hard tissue makes it difficult for a child's lungs to function properly. As pulmonary fibrosis worsens, the patient becomes increasingly short of breath.
Pulmonary fibrosis in premature infants, if not detected early and treated promptly, can easily lead to dangerous and fatal complications.

2. Causes of pulmonary fibrosis in infants


Trẻ phải sử dụng thuốc hóa trị - Methotrexate có thể gây xơ phổi
Trẻ phải sử dụng thuốc hóa trị - Methotrexate có thể gây xơ phổi
Children long-term exposure to a number of toxins and pollutants can damage their lungs: Silica dust, Asbestos fibers, heavy metals, coal dust, bird and animal droppings,... Some children are exposed to Radiation during radiation therapy can cause pulmonary fibrosis. Medications: Chemotherapy drugs (drugs designed to kill cancer cells, such as methotrexate, cyclophosphamide), Heart medications (amiodarone), antibiotics (Macrobid, Macrodantin, ethambutol), Anti-inflammatory drugs (rituximab) , sulfasalazine) Lung damage can also result from a number of conditions, including: Atopic dermatitis, polymyositis, mixed connective tissue disease, systemic lupus erythematosus, rheumatoid arthritis, scleroderma. , pneumonia,... There are many substances and diseases that can lead to pulmonary fibrosis. Even so, in most cases, the cause is usually not identified. Pulmonary fibrosis without a cause is called idiopathic pulmonary fibrosis.

3. Symptoms of pulmonary fibrosis

Signs and symptoms of pulmonary fibrosis may include:
Shortness of breath Dry cough Fatigue Unexplained weight loss Muscle and joint pain.

4. Complications of pulmonary fibrosis in infants


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Suy tim phải là biến chứng của xơ phổi ở trẻ sơ sinh
Complications of pulmonary fibrosis in infants can include:
4.1 Pulmonary hypertension Pulmonary hypertension affects the arteries in the child's lungs. It begins when the smallest arteries and capillaries are compressed by scar tissue, increasing resistance to blood flow in your lungs. This in turn increases pressure in the pulmonary arteries and the lower right chamber of the heart (the right ventricle). Some forms of pulmonary hypertension are serious illnesses that gradually get worse and are sometimes fatal.
4.2 Right Heart Failure This serious condition occurs when the right ventricle pumps harder than usual to push blood through the partially blocked pulmonary arteries.

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ung thư phổi là biến chứng nặng của bệnh xơ phổi
4.3 Respiratory failure This is usually the end stage of chronic lung disease. It occurs when the oxygen level in the blood drops to dangerously low levels.
4.4 Lung cancer Persistent pulmonary fibrosis also increases the risk of developing lung cancer.
4.5 Lung Complications As pulmonary fibrosis progresses, it can lead to complications such as a blood clot in the lung, a collapsed lung, or a lung infection.

5. Diagnosis of pulmonary fibrosis in premature infants


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Chụp X-quang ngực giúp chẩn đoán xơ phổi ở trẻ sinh non
To diagnose pulmonary fibrosis, the physician takes medical history, family history, checks for signs and symptoms, considers any exposures the patient has had (dust, gases, and chemicals), and will use a stethoscope to listen carefully to your baby's lungs while he or she breathes. In addition, your doctor may recommend one or more of the following tests:
Chest X-ray: A chest X-ray may show the typical scar tissue of pulmonary fibrosis, and it may be helpful for monitoring. disease process and treatment Computerized tomography (CT): CT scanners use a computer to combine X-ray images taken from many different angles to create cross-sectional images of internal structures body. Echocardiogram : Helps assess the amount of pressure occurring in the right heart Pulmonary function test: Several types of lung function tests may be performed. Arterial blood gas test. Blood oxygen saturation Lung biopsy: If other tests fail to diagnose the condition, doctors may need to remove a small amount of lung tissue (biopsy). The biopsy is then examined in a laboratory to diagnose pulmonary fibrosis or rule out other conditions.

6. Treatment of pulmonary fibrosis in premature infants


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Ghép phổi
Pulmonary scarring occurs in irreversible pulmonary fibrosis and no current treatment has been shown to be effective in halting disease progression. Some treatments can temporarily improve symptoms or slow the progression of the disease. Others may help improve quality of life. Doctors will assess the severity of your condition to determine the most appropriate treatment for your condition.
Drug use: pirfenidone and nintedanib. These drugs can help slow the progression of idiopathic pulmonary fibrosis. Oxygen therapy Pulmonary rehabilitation can help manage symptoms and improve everyday lung function A lung transplant may be an option for people with pulmonary fibrosis. However, lung transplantation can be associated with complications such as rejection and infection. The doctor can discuss with the child's family if a lung transplant may be appropriate for the child's condition. Vietnam is the first country in the world to announce a successful stem cell transplant to treat pulmonary fibrosis in premature babies. In 2017, Vinmec Time City International Hospital applied stem cell transplantation from bone marrow in the treatment of pulmonary fibrosis for 3 patients and all 3 were cured. After about 3 weeks to 1 month of stem cell transplantation, the patient was weaned from oxygen, was able to breathe on his own and the pulmonary fibrosis gradually disappeared (about 6 months).
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