Precautions while using Clobetasol 0.05%

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1. Uses of Clobetasol 0.05% 1.1. Indications Ingredient Clobetasol 0.05% is the active ingredient Clobetasol propionate, belongs to the group of topical drugs and is indicated in the treatment of the following conditions:
Short-term local treatment (less than 2 weeks) for redness conditions , pruritus, scaly, scaly skin, eczema , psoriasis, dermatitis and other uncomfortable skin conditions; Short-term treatment of dermatitis and eczema such as photodermatitis, atopic eczema, atopic dermatitis, otitis externa, itchy papules, insect bites, seborrheic dermatitis. 1.2. Pharmacokinetics Active ingredient Clobetasol propionate has a low degree of absorption through the skin, so it is often used in the topical treatment of atopic dermatitis. However, when preparations containing Clobetasol propionate are applied to the skin, a certain amount of the drug is still absorbed through the skin. Especially in the case of damaged skin, the absorption capacity will increase. Therefore, caution should be exercised when using the drug with open wounds. The extent of drug absorption through the skin is influenced by many factors including the integrity of the epidermal barrier, the amount of drug applied to the skin, the excipients used in the formulation, the length of the dressing, and other skin conditions. . The drug in the form of a gel is better absorbed than the drug in the form of a cream.
Currently, there are no studies demonstrating whether Clobetasol Propionate is distributed into milk. The drug metabolism takes place in the liver and is eliminated by the kidneys, partly through the bile and then excreted in the feces.

1.3. Pharmacodynamics Active ingredient Clobetasol Propionate belongs to the group of synthetic corticosteroids similar to Prednisolone, very strong Glucocorticoid activity and weak Mineralocorticoid activity, so it is used to treat local skin diseases.
In case the skin is damaged, applying a large amount of the drug or when the skin is covered with a bandage after application, the drug may be absorbed larger than usual and cause systemic side effects. Similar to other topical corticosteroids, Clobetasol Propionate is an active ingredient with anti-allergic, anti-inflammatory and vasoconstrictor effects.
The mechanism of the anti-inflammatory action of Clobetasol Propionate is still unknown. The drug can induce proteins called Lipocortin – Phosphorylase A 2 inhibitor. These proteins play a role in controlling the biosynthesis of potent inflammatory mediators such as Leucotriene, Prostaglandin through inhibition of dissolution. Releases Arachidonic Acid - a common precursor of Leucotriene and Prostaglandin.

2. Dosage of clobetasol 0.05% Dosage and usage in adults are as follows:
Apply a thin layer of the drug and gently rub it on the affected skin, use it twice a day in the morning and evening; In case of scalp disease, it is recommended to use foam form, 2 times a day in the morning and evening. After applying the medicine, it should be left open, only covered when prescribed by a doctor; Active ingredient Clobetasol 0.05% has a very strong effect, so patients only apply a sufficient amount of medicine to the area to be treated, not more than 2g at a time. In case the treated skin area is too large, the patient should also note that do not use more than 50g per week and do not use more than 2 weeks; Stop taking the medicine when the disease is cured. In case of taking the drug for 2 weeks but no response, the drug must be stopped and the diagnosis should be reviewed; Clobetasol 0.05% is formulated in the form of a cream containing emollient (Emollient Cream), when used in the treatment of moderate or severe plaque psoriasis with an area of ​​​​5 - 10% of the body can be used up to 4 weeks. However, from the 3rd week, regular monitoring of hypothalamic-pituitary-adrenal axis suppression is required; Clobetasol 0.05% medicine is prepared in many different topical forms, so patients need to carefully read the instructions for use attached to the product to achieve high treatment efficiency. Dosage and administration in children:
Children over 12 years old: Dosage and administration are the same as for adults; Children under 12 years: Contraindicated to use Clobetasol 0.05% for children in this subject.

3. Side effects when using Clobetasol Some unwanted effects (ADRs) that can be encountered when using Clobetasol 0.05% are as follows:
Common reactions: Sharp pain, burning in the application area like insect bites. insect bites ; Uncommon reactions: Folliculitis, itching, dry skin, skin rash, fungal or bacterial skin infections. Rare reactions: Skin cracking, skin atrophy, frostbite, skin with acne-millet appearance, perioral dermatitis, hypopigmentation, allergic contact dermatitis. In case the drug is absorbed a lot through the skin into the circulation, it will inhibit the hypothalamic-pituitary-adrenal axis, thereby causing adrenal insufficiency, hyperglycemia, Cushing's syndrome and glucoseuria in some patients.
4. Note when taking Clobetasol 4.1. Contraindications Clobetasol 0.05% is contraindicated in the following cases:
Children under 12 years old; People with acne and rosacea , perioral dermatitis, extensive psoriasis; Do not use drugs for oral or eye contact; Do not apply the medicine to the face, armpits, groin or vagina; People who are allergic to Corticosteroids or any of the ingredients in Clobetasol Propionate; Skin lesions caused by fungi, viruses, bacterial infections mainly of the scalp, fungi, viruses or tuberculosis of the skin. 4.2. Note when using Clobetasol Propionate is a strong drug, it should be used as directed by a doctor. The drug is only for external use, do not use it for longer than the indicated time, do not cover the area of ​​application unless directed by a doctor, do not abuse the drug for inappropriate cases.
In the event of symptoms of undesirable effects, or extensive drug use, the patient should be assessed for the functioning of the hypothalamic-pituitary-adrenal axis. (HPA) periodically through specific tests.
For children, the ratio of skin area to body weight is larger than that of adults, so they are more susceptible to HPA axis suppression and Cushing's syndrome when using topical corticosteroids, increasing the risk of adrenal insufficiency in and after taking the drug. Therefore, clobetasol is contraindicated in children under 12 years of age.
For the elderly (over 65 years old) no difference in efficacy and adverse events compared with young people. However, the lowest possible dose should be used.
In case the patient has a fungal infection and a bacterial infection at the same time during Clobetasol 0.05% treatment, it is necessary to combine with appropriate antibiotics and antifungal drugs. In case of fungal or bacterial infections that cannot be controlled immediately, the patient should stop taking Clobetasol until the fungal infection or bacterial infection is controlled.

4.3. Effects of the drug on special subjects For pregnant women: There are currently no specific studies proving the effect of Clobetasol 0.05% on the fetus. However, the drug can be absorbed through the skin, so the benefits and risks for mother and fetus need to be weighed. In case of real need to use, be careful not to use too high a dose and for a long time. For women who are breast-feeding: There have been no studies on the effects of the drug on women who are breastfeeding, but in case of heavy use and long-term use, breast-feeding should be limited. For operating machines, drivers: There are no studies showing the effect of Clobetasol on the ability to drive or use machines.
5. Treatment of overdose and missed dose of Clobetasol Using an overdose of Clobetasol increases the absorption of drugs through the skin into the circulation. In case the drug dose is absorbed through the skin large enough, it will cause systemic complications, especially the syndrome. Cushing, adrenal insufficiency, hyperglycemia and hyperglycemia.
Treatment in case of overdose: Stop taking the drug immediately after overdose, this will help the function of the hypothalamic-pituitary-adrenal axis to be restored quickly. However, some cases of drug discontinuation will show glucocorticoid deficiency, requiring corticosteroids for a while.
In case of forgetting to apply a dose, the patient should apply it when he remembers it as soon as possible. If it is almost time for the next dose, you can skip the missed dose and take your next dose at the scheduled time. Be careful not to take a double dose if you forget. Clobetasol 0.05% topical medicine contains the active ingredient Clobetasol, which is used for short-term treatment of redness, itching, scaly skin, scaling, eczema, contact dermatitis and other uncomfortable conditions of the skin. . To ensure the effectiveness of treatment and avoid side effects, patients need to strictly follow the instructions of the doctor or pharmacist.
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