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Androcur 50mg drug has the effect of reducing sexual desire when there are false sexual manifestations. In addition, the drug is also used in the treatment of inoperable prostate cancer, baldness, hair loss, excessive hair growth,... Let's learn more about Androcur, what is the drug? What notes when using the drug through the following article.
1. What is Androcur? Ingredients of the drug
Androcur 50mg is a hormonal drug that effectively reduces libido. Androcur inhibits the effects of androgens on the body. Decreases libido and sex drive in men. In women, the function of the ovaries is suppressed. The composition of the drug Androcur 50mg includes the active ingredient Cyproterone acetate (50mg), excipients with sufficient content. Prepared in the form of 1 tablet.
2. Uses of Androcur 50mg in the treatment of diseases
Androcur drugs are used to treat specific subjects:
In men:
Decreased libido in case of sexual perversion; Anti-androgen drugs are treating prostate cancer, which cannot be operated on. In women:
Cases with signs of virilization such as hair growth, acne growth, sebum secretion and excessive hair loss.
3. Use the correct dose of Androcur medicine
Androcur tablets are administered orally. The drug is mainly intended for adults and people over 18 years of age. However, before use should read the instructions carefully before using the drug.
Androcur is usually taken with water after meals, with a maximum daily dose of 300mg.
3.1. Decreased libido when sexually perverted in men
In this case, the starting dose will be used 2 times / day and 1 tablet of 50 mg each time. When necessary, the dose can be increased to 2 tablets / day and taken 2 times a day. Can be taken 3 times a day with 2 tablets each time. However, should only drink for a short time and then stop.
Once the desired results have been achieved, treatment should be maintained at the lowest possible dose. Usually 1⁄2 tablets and 2 times per day are enough. The maintenance dose should be established or when treatment is discontinued, the dose should not be reduced abruptly, it should be gradually reduced. By reducing the dose to 1 tablet/day or 1⁄2 tablets/day.
To stabilize the therapeutic effect, it is necessary to take Androcur for a long time. Can be combined with psychotherapeutic measures.
3.2. Anti-androgen treatment in prostate cancer This case will take 2-3 times a day and take 2 tablets of 50mg each time. Do not stop taking the drug or reduce the dose suddenly when there is improvement or remission of the disease.
To reduce the increase of sex hormones in men. May be combined with GnRH agonists during the initial period of treatment.
Initially, men will take this medicine 2 times a day and take 2 50 mg tablets each time. The duration of treatment will take place in 5-7 days. Then, combine 2 oral 50mg tablets with 1 GnRH agonist tablet at the manufacturer's recommended dose for 3 to 4 weeks.
For the treatment of hot flashes when using GnRH agonists or in orchiectomy patients, men will take 1-3 tablets of 50 mg (50-100 mg) daily, increasing to 2 tablets if necessary. 3 times/day (300mg).
3.3. Women of reproductive age
Pregnant women absolutely should not use. In women of childbearing age, treatment is given on the first day of the menstrual cycle. However, in women with amenorrhea, prescription treatment can be started right away.
Normally, women will take 1 time / day and take 2 tablets of 50mg each time, during 1 to 10 days of the menstrual cycle. At the same time, women must take 1 pill with Progesterone and Estrogen (for example, from day 1 to 21 of the cycle, take 1 tablet of Diane 35 per day, to prevent pregnancy and stabilize the menstrual cycle).
Every 21 days will take 7 days off the medicine. After 4 weeks of starting treatment, the next treatment will be continued regardless of whether or not menstruating or not. After the treatment improves, the dose can be reduced to 1- 1⁄2 tablets of 50mg per day, lasting for the first 10 days of the combined treatment with Diane 35.
In the absence of menstruation: During no period Menstruation should be discontinued to exclude the possibility of pregnancy before treatment; In case of forgetting to take a pill: It is recommended to take it according to the cycle of the drug and take it at a fixed time of the day. If you forget to take Androcur for more than 12 hours, it will reduce the effectiveness of contraception during the cycle, reduce the effectiveness of treatment, and bleed between cycles. It is best to pay attention to the time of taking the medicine when using it. Do not increase the dose on your own to make up for the missed dose; After menopause, hysterectomy: In this case, Androcur can only be used. Depending on the severity of symptoms can be used from 1-1⁄2 tablets of 50mg/day. Stop the drug immediately after 7 days of treatment.
3.4. Use of Androcur in children and young adults
Androcur is indicated in women who have passed puberty. Dosage is the same as usual. In addition, Androcur is not used in young men and children under 18 years of age because there are no accurate conclusions about safety and effectiveness. The drug should not be used before puberty because it can affect the development of the body. Unstable function of endocrine glands.
3.5. Use of Androcur in the elderly There have been no results indicating the need for dose adjustment in the elderly. The use of Androcur is contraindicated in women with liver disease. Patients with renal impairment do not really need to adjust the dose.
4. Contraindications of Androcur 50mg
Below are the contraindications to taking the drug in men and women. Specifically:
Androcur is not recommended for use in young men and children under 18 years of age. Indicated to reduce libido in cases of sexual deviation. In men treated for inoperable androgen-resistant prostate cancer. However, the drug is not recommended to be used in the following cases:
People with liver disease; Have Dubin-Johnson syndrome and Rotor syndrome; Have liver tumor, meningioma (history of having or currently having); Severe chronic depression; Past and at risk of thromboembolic processes; Have severe diabetes; Red blood cell anemia; Allergy to drugs. In women:
Females have not yet reached puberty; Women who are pregnant and breastfeeding; Have liver disease; Dubin-Johnson syndrome and Rotor syndrome; A history of persistent jaundice and itchy skin in a previous pregnancy; Herpes infection of pregnancy; Have liver tumor, meningioma (history of having or currently having); Severe chronic depression; Past and at risk of thromboembolic processes; Have severe diabetes; Red blood cell anemia ; Allergy to drugs.
5. Side effects
When using Androcur drugs, there may be some side effects for men and women as follows:
In men:
In patients using Androcur drugs often decrease sexual desire, dysfunction erection and reverse spermatogenesis. In addition, it inhibits gonadal function, causing breast enlargement and tenderness. However, these changes are reversible upon discontinuation of the drug; Serious reactions can cause hepatotoxicity, intra-abdominal bleeding, thromboembolism; Several weeks after treatment, the antiandrogen and antigonadotropin effects inhibit spermatogenesis. Sperm production will be restored gradually after a few months of stopping the drug; Meningioma cases have been reported in association with long-term (several years) use of Androcur at doses of 25 mg or higher. In women:
The most common adverse reaction with Androcur 50 mg use was spot bleeding. drops, weight gain and depression. The most serious reactions are hepatotoxicity, benign and malignant liver tumors. This can lead to intra-abdominal bleeding and thromboembolism. Combination treatment inhibits ovulation, thereby causing infertility. When it is necessary to combine treatment with Diane-35, it is important to note the undesirable side effects of this drug. Benign meningiomas have been reported in association with long-term (several years) use of Androcur at doses of 25 mg or higher. Androcur drugs have the effect of reducing sexual desire when there are false sexual manifestations, treatment of inoperable prostate cancer, hair loss, excessive hair growth,... To ensure safety To maximize the effectiveness of treatment, patients need to use the drug exactly as prescribed by the doctor.
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