Oresol User Manual

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Posted by CCII Doctor Bui Thu Huong - Head of Emergency, Day Treatment Unit - Pediatric Center - Vinmec Times City International Hospital.
Oresol is a drug that works to rehydrate patients, used to replace lost water and electrolytes in the following cases: acute diarrhea, vomiting, high fever, grade I, II, III hemorrhagic fever. if the child can drink it) or when doing physical activities, working for a long time in a hot environment...

1. What is Oresol?

ORS (Oral Rehydration Salts) is an oral rehydration powder that, when mixed with water, becomes Oresol. Currently, the World Health Organization (WHO) has guidelines for a new type of ORS that has the same osmotic components as a regular ORS package, but the content is changed to be able to mix with water with low salt and sugar concentrations. help shorten the duration of diarrhea and reduce the number of cases requiring intravenous fluids.

2. New ORS Component

Formula: Each 4.1g pack contains:
Sodium chloride ............. 520 mg Sodium citrate ....... .. 580 mg Potassium chloride .................. 300 mg Glucose anhydrous ............. 2.7 g Excipients just enough ................ ...... 1 package

3. Principle of using ORS

The small intestine plays an important role in the regulation of water and electrolyte balance between plasma and intestinal lumen. Intestinal intercellular water exchange is regulated mainly by osmotic pressure gradients caused by solute transport, in which Na+ plays an important role.
Na+ is transported from the intestinal lumen into cells by 3 main mechanisms:
Exchange with 1 H+ ion Attach to chloride Attach to Glucose or peptide on the carriers When Glucose enters the body, it will increase the absorption of Na from the lumen. intestines into the bloodstream 3 times. The pairwise uptake of Na and Glucose is the basic principle of glucose utilization in ORS solution. Therefore, when having diarrhea, taking ORS increases the absorption of Na+, which in turn leads to water.

4. Specify the use of ORS

Used in the treatment of dehydration caused by diarrhea in children and adults Used to replace lost water and electrolytes in the following cases: Acute diarrhea, vomiting, high fever, dengue grade I, II, III (if the child can drink) When doing physical activities (playing sports, exercising hard, athletes, people who work for a long time in a hot environment, ...)

5. Contraindications to the use of ORS

Anuria, prolonged oliguria, persistent vomiting, (requires fluid transfusion), high fever with convulsions, coma Patients with: impaired glucose tolerance, acute renal failure, intestinal obstruction, paralytic ileus, intestinal perforation Hypersensitivity to any ingredient of the drug

6. How to use ORS

Mix 1 sachet with 200ml of cooled boiled water Prevention of dehydration due to acute diarrhea: according to protocol A, B Prevention of dehydration in other cases (not due to diarrhea): Drink Oresol 245 solution in sips according to ability and need

7. Pay attention when mixing ORS 245

Mix Oresol 245 sachet right before use. Once mixed, it can be kept for 24 hours, after which it should not be used. Use cold water to mix Oresol 245 solution, do not mix Oresol 245 with mineral water because in mineral water there are electrolytes that will distort the ratio of electrolytes in Oresol 245, after mixing, do not boil the solution. Oresol 245 Do not mix with milk, broth, juice or soft drinks... and absolutely do not add sugar When mixing Oresol 245 solution into water, we get a cloudy solution, always shake or stir thoroughly before mixing. drink Do not boil the prepared solution. Wash your hands with soap before preparing
Do not arbitrarily split the Oresol package, causing the components to be heterogeneous. Do not dilute Oresol at the wrong rate. Do not mix Oresol thicker than directed, it will make blood osmotic pressure higher, causing cells to shrink due to dehydration. Symptoms of children are often wrinkled skin, dry eyes, convulsions, brain atrophy, coma, ... When mixing Oresol, you must carefully read the instructions in the Oresol package, do not mix it wrong because it will be dangerous for the baby.
Pediatrics department at Vinmec International General Hospital is the address for receiving and examining diseases that infants and young children are susceptible to: viral fever, bacterial fever, otitis media, pneumonia in With modern equipment, sterile space, minimizing the impact as well as the risk of disease spread. Along with that is the dedication from the doctors with professional experience with pediatric patients, making the examination no longer a concern of the parents.

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