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Lymph node hyperplasia is a rare disease, little known or heard about. The following article will help you better understand this disease.1. What is lymph node hyperplasia?
Lymph node hyperplasia (Castleman disease) is a rare disorder that involves the overproduction of cells in the body's lymph nodes. The most common form of the disease is hyperplasia of only one lymph node, usually in the chest or abdomen.Multi-lymph node hyperplasia affects lymph nodes throughout the body, and is associated with human herpes virus type 8 (HHV-8) and human herpes virus. human immunodeficiency virus (HIV).
Treatment and prognosis of lymph node hyperplasia depends on the specific disease condition. If there is only one lymph node hyperplasia, treatment is usually successful after surgery.
2. Lymph node hyperplasia symptoms
Many patients with only one lymph node hyperplasia often do not have any signs or symptoms. The discovery of enlarged lymph nodes is often incidental, during clinical examination or during imaging (with the primary purpose of serving another medical problem).However, some patients with single-lymph node hyperplasia may also develop signs and symptoms commonly seen in patients with multi-lymph node hyperplasia, including:
Fever; Weight loss (unintentional); Tired; Night sweats; Nausea; Enlarged liver, or enlarged spleen. In patients with multiple lymph node hyperplasia, enlarged lymph nodes are most common in the neck, clavicle, axillary, and inguinal regions.
Mệt mỏi, sụt cân là những triệu chứng thường thấy ở bệnh nhân tăng sản nhiều hạch bạch huyết
3. Lymph node hyperplasia when to see a doctor?
If you notice enlarged lymph nodes in your neck, collarbone, armpit or groin area, see your doctor. Also, contact your doctor if the following signs persist: feeling of fullness in the chest or abdomen, fever, fatigue, or unexplained weight loss.4. Causes of lymph node hyperplasia
Until now, the cause of lymph node hyperplasia is unknown. However, infection with human herpes virus type 8 (HHV-8) is associated with multiple lymph node hyperplasia.Herpes virus type 8 has also been linked to the development of Kaposi's sarcoma, a malignant tumor that is a complication of HIV and AIDS. Studies have shown that human herpes virus type 8 is present in nearly all cases of HIV-positive lymph node hyperplasia, and in about half of all HIV-negative cases of lymph node hyperplasia. .
5. Risk factors for lymph node hyperplasia
Lymph node hyperplasia can occur at any age, but the average age of patients diagnosed with single-lymph node hyperplasia is 35. Patients with multi-lymph node hyperplasia are most commonly at this age. age 50 and 60, and is more common in men than in women.The risk of developing multiple lymph node hyperplasia is increased in subjects infected with human herpes virus type 8.
6. Complications of lymph node hyperplasia
Mắc bất kỳ dạng nào của tăng sản hạch bạch huyết đều làm gia tăng nguy cơ bị u lympho
Having any form of lymph node hyperplasia increases the risk of lymphoma.
7. Diagnosis of lymph node hyperplasia
After the clinical examination, the doctor may order some of the following laboratory tests and techniques:Blood tests, urinalysis To assist in the detection of other diseases or infections. These tests also help look for anemia and protein abnormalities in the blood (conditions often characteristic of lymph node hyperplasia)
Imaging techniques To detect the condition enlargement of the lymph nodes, liver, or spleen. Computed tomography scan (CT scan) or magnetic resonance imaging (MRI) of the neck, thorax, abdomen, or pelvis may also be ordered. Positron emission tomography scan (PET scan) can be used to diagnose and monitor the outcome of treatment for lymph node hyperplasia.
Lymph node biopsy For the differential diagnosis of lymph node hyperplasia from other types of lymphoproliferative disorders, such as lymphoma. A tissue sample will be taken from the abnormally growing lymph node for pathology.
Xét nghiệm máu, xét nghiệm nước tiểu nhằm hỗ trợ tình trạng bệnh hoặc tình trạng nhiễm khuẩn khác
8. Treatment of lymph node hyperplasia
The treatment for lymph node hyperplasia will depend on the patient's condition.
8.1 Treatment of single-lymph node hyperplasia Single-lymph node hyperplasia is treatable by surgically removing the diseased lymph node. In cases where the diseased lymph node is located in the thorax or abdomen (very common), complex surgery may be required.
If surgical removal of the diseased lymph node cannot be performed, medication can be used. Radiation therapy that destroys the diseased lymph node is also an effective method.
After treatment, patients need to follow-up appointments and perform tests (including imaging) to monitor recurrence.
8.2 Treatment of multiple lymph node hyperplasia Treatment of multiple lymph node hyperplasia often requires medications and therapies to control cell overgrowth. Specific treatment should be based on disease severity as well as HIV infection and human herpes virus infection.
Treatment for multiple lymph node hyperplasia usually includes:
Immunotherapy: Medications such as siltuximab (Sylvant) or rituximab (Rituxan) may be used. Chemotherapy: To slow cell proliferation, and is often indicated when patients do not respond to immunotherapy or when there is already organ failure. Corticosteroids: Anti-inflammatory drugs such as prednisone can be used. Antiviral drugs: Can block the activity of HIV virus and human herpes virus type 8.
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Reference source: mayoclinic.org
