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Currently on the market there are many preparations of 5 Alpha reductase of countries in the form of tablets and capsules. One with 1 mg for the treatment of androgenetic alopecia in men (Propecia, generic). One with 5 mg to treat an enlarged prostate (Proscar, strain). Join Vinmec to learn more about 5 Alpha reductase inhibitors in this article.
1. What is an enlarged prostate gland?
According to WHO, the number of men with benign prostatic hypertrophy (BPH) at the age of 60 is 59%, at the age of 70 it is 76.9%, over 80 years old is 90%. In today's life, the population's life expectancy is increasing, this is also one of the reasons why the rate of men with the disease, as well as the severity of benign prostatic hypertrophy, increases.
The cause of the disease is the hyperplasia of the structural cells of the prostate gland. Then cause symptoms of urinary disorders. Early detection and treatment can prevent complications.
Medical treatment is treatment based on the use of drugs and monitoring of disease progression. This method of choice is safe and is indicated when the disease has not caused complications. The main treatment drugs include Alpha inhibitors and 5-Alpha reductase inhibitors. Some alpha-blockers such as Alfuzosin (Xatral), Indoracin, Terazosin hydrochloride (Hytrin), Doxazosin aresylate (Carduran) have a mechanism to reduce smooth muscle spasms in the prostate, glandular cortex and bladder neck, thereby improving symptoms rapidly. A group of drugs that inhibit the activity of 5-Alpha reductase enzymes have a marked effect on reducing prostate volume.
2. What are 5 Alpha reductase inhibitors?
5 Alpha reductase inhibitors (ATC G04CB) are effective against symptoms of an enlarged prostate. It helps to reduce prostate size and stabilize hair loss in male hormonal alopecia. Some effects are based on inhibition of the local intracellular enzyme 5α-reductase, which is responsible for the synthesis of 5α-dihydrotestosterone (DHT) from testosterone. DHT will play a role in the development of both prostate enlargement and endogenous alopecia areata.3. Active ingredients of 5 Alpha reductase inhibitors
The active ingredients of 5 Alpha reductase inhibitors include:
Finasteride (Propecia 1 mg, generic) - Hair loss in men. Finasteride (Proscar 5 mg, strain) - Enlarges the prostate gland. Dutasteride + tamsulosin (Alpha blocker) (Duodart, fixed combination). Dutasteride (Avodart, generic).
4. Indications for taking 5 Alpha reductase inhibitors
5 Alpha reductase inhibitors are indicated in the following cases:
Benign prostatic hypertrophy in men Hereditary hair loss in men (intragenic alopecia) Dosage of the drug according to the instructions of the doctors. specialist doctor. The recommended dose is once a day.
5. Contraindications to using 5 Alpha reductase
5 Alpha reductase inhibitors are contraindicated in the following cases:
People with hypersensitivity to any ingredient of the drug Do not use for women, children and adolescents.
6. Side effects of 5 Alpha reductase inhibitors
When using the drug, you may experience some of the following side effects:
Ejaculation disorders Impotence, erectile dysfunction Decreased libido The above is the basic information about 5 Alpha reductase inhibitors, To use the drug most effectively, you should see a doctor and consult a specialist. Do not arbitrarily buy and use drugs to avoid unwanted side effects.
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