Dapoxetin drug in the treatment of premature ejaculation: Uses, side effects and notes when using the drug

This is an automatically translated article.


Posted by Pharmacist Huynh Xuan Loc - Faculty of Pharmacy - Vinmec Central Park International General Hospital
Dapoxetine is used in the treatment of premature ejaculation in adult men aged 18 to 64 years. The drug has been shown to prolong the time needed before ejaculation and improve male control in this regard.

1. How does Dapoxetine work?

Dapoxetin, commonly known as Priligy, belongs to a class of selective serotonin reuptake inhibitors (SSRIs) used to treat premature ejaculation in adult men aged 18 to 64 years. age. Dapoxetin has been shown to prolong the time required before ejaculation and improve male control in this regard. Studies have also shown the effectiveness of the drug in reducing anxiety and frustration in men in the context of premature ejaculation.

2. Rational use of Dapoxetine drug


Dapoxetin 30mg is a prescription drug, so patients should not self-medicate without a doctor's prescription. Furthermore, the correct diagnosis of premature ejaculation needs to be reviewed and evaluated by a specialist to rule out other conditions with similar manifestations.
Patients need to inform the treating doctor if they have cardiovascular diseases (heart failure, arrhythmia ...), history of syncope, psycho-neurological disorders (mania). , major depression, bipolar disorder, epilepsy, schizophrenia ) , glaucoma, liver disease, kidney disease, blood clotting disorder ...
In addition, the patient should also list the medications being taken. use or recent use including other herbal or dietary supplements.
Special attention should be paid to drugs for depression (monoamine oxidase inhibitors - MAOIs, lithium, nefazodone ...), antibiotics (linezolid, telithromycin ...), antifungals (ketoconazole, itraconazole .. .), antiviral (amprenavir, fosamprenavir,...), sedative, hypnotic (trytophan, benzodizepine), pain reliever (tramadol) or migraine medication... because these drugs should not be used concurrently with dapoxetine.
In case of necessity, the patient should discuss with the treating doctor about the continuation of Dapoxetine use with these drugs: either stop other drugs 14 days then start dapoxetin or stop dapoxetin 7 days later use other drugs.

Bệnh nhân mắc bệnh suy tim nên thận trọng khi uống thuốc dapoxetin
Bệnh nhân mắc bệnh suy tim nên thận trọng khi uống thuốc dapoxetin

3. Common side effects when taking Dapoxetine


Many people think that Dapoxetin is the most effective treatment for premature ejaculation, so they self-abuse without consulting a doctor. In fact, Dapoxetin, like other drugs, has the potential to cause undesirable effects in a certain proportion of patients.
Accordingly, patients need to stop using Dapoxetine and see a doctor immediately if they experience the following conditions: convulsions, fainting or feeling dizzy when standing up, mood changes, suicidal thoughts or hopes want to harm themselves.
Dapoxetine medicine can also cause fainting or low blood pressure when the patient stands up or changes position suddenly, especially when dehydrated due to not drinking enough water within 4-6 hours before taking the drug, due to heat. , sweat for a long time or are suffering from diseases causing hyperthermia, diarrhea ... other.
In addition, other common side effects include dizziness, headache, drowsiness (>1/10 people taking the drug), irritability, anxiety or lethargy, flushing or sweating, and diarrhea. , digestive disorders , flatulence , sleep or somnolence disorders , fatigue , nasal congestion , loss of concentration , tinnitus , blurred vision , dry mouth (=< 1/10 people taking the drug) ...
People Patients should inform their doctor about these undesirable effects or any other disorder suspected to be caused by the drug.

4. Notes when using Dapoxetin


Proper use of Dapoxetin helps promote the effect of the drug and minimize side effects (if any). The drug is available in two strengths: Dapoxetin 30mg and 60mg. Accordingly, the patient needs to take the prescribed dose and not arbitrarily increase the dose without consulting the treating doctor. Take the drug within 1-3 hours before the expected time of sexual activity and do not take more than once in 24 hours.
Accordingly, you should note, the drug is not used for women. Swallow the tablet whole with a full glass of water to avoid a bitter taste and reduce the risk of dehydration leading to fainting or low blood pressure. Patients also need to fully replenish water, avoid dehydration during 4-6 hours before taking the drug.
Do not stand or sit up suddenly after taking the medicine and do not drive or operate machinery if the patient does not feel well after taking the medicine.
After taking Dapoxetine or when changing positions suddenly, if you feel dizzy, light-headed, sweaty or have a heart rhythm disorder, the patient should lie down immediately, keep the head lower than the body or sit. Bend your head down and put it between your knees until you feel better. This helps reduce the risk of falls and injury from fainting. If the patient faints after taking the drug, notify the treating physician.
Patients need to have regular health check-ups or talk to their doctors again after 4 weeks or 6 doses of the drug to evaluate the effectiveness of treatment. If indicated to continue taking the drug, the patient should periodically re-examine at least once every 6 months to monitor treatment.

Thuốc dapoxetine 30mg có thể khiến người bệnh cảm thấy chóng mặt khi đột ngột thay đổi tư thế
Thuốc dapoxetine 30mg có thể khiến người bệnh cảm thấy chóng mặt khi đột ngột thay đổi tư thế

5. Drug interactions with food and alcohol


Do not use grapefruit juice (grapefruit) within 24 hours before taking the drug because the interaction increases the concentration of the drug in the body causing harmful effects. Dapoxetin can be taken with or without food
Take the medicine with water and not with alcohol or other alcoholic beverages due to the increased risk of side effects such as dizziness, drowsiness, slow reflexes as well. such as increased risk of injury or falls if drug-induced fainting occurs. Dapoxetine is used in the treatment of premature ejaculation in adult men aged 18 to 64 years. This is a prescription drug, so patients should not use it on their own, but should strictly follow the instructions of the doctor or pharmacist. During use, if there are abnormal signs, patients need to go to medical centers for examination and treatment.

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References:
Priligy 30 mg film-coated tablets, Patient information leaflet, https://www.medicines.org.uk/emc/product/1269/pil Priligy, drug leaflet
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