This is an automatically translated article.
Gastric ulcer is the most common pathology of the gastrointestinal tract. Although the treatment of stomach diseases is simple, it is necessary to strictly follow the treatment regimen. If you do not take enough stomach medicine and even arbitrarily take drugs that cause stomach pain, it will make the disease even more serious, which can lead to dangerous complications.
1. Harm of inadequate stomach medicine
Inadequate gastric medication intake is reflected in 3 aspects: Self-stopping, taking the wrong type of medication and arbitrarily changing drugs:
Self-stopping: Some patients have stomach pain but when taking the drug After 3 to 5 days, the stomach pain will be gone, the vomiting will be gone, you will feel better, so you should stop taking the drug or reduce the dose on your own. Such half-dosing will cause a reverse reflex such as increasing gastric acid secretion more. In simple terms, if you are taking stomach medicine according to the progress of the disease, but you stop taking the medicine suddenly, the parietal cells will simultaneously increase acid secretion. As a result, more acid is produced. Inadequate treatment and non-compliance with the treatment regimen will make the stomach disease worse, less responsive to treatment, leading to gastric ulcer. Taking the wrong medicine: Gastric ulcers will be treated specifically with acid-suppressing drugs. Taking the wrong medicine not only does not reduce acid secretion, but also causes additional harm to the stomach. Arbitrarily changing drugs: Treatment of stomach ulcers requires compliance with the course (right medicine, enough medicine, enough days), if the patient arbitrarily changes the drug to another type, it may cause stomach pain which is already near. The disease will recur, or become chronic inflammation and progress to gastric cancer.
Diclofenac là một trong các loại thuốc gây đau dạ dày
2. Medicines that cause stomach upset
Currently, there are many drugs that cause stomach pain are widely sold in the market. Each drug has its own specific treatment indication. If you do not take the medicine without the doctor's permission, it will make the stomach ulcer worse and worse, possibly causing a perforation of the stomach or stomach cancer. The drugs cause stomach pain mainly by two main mechanisms: Direct irritation causing damage to the gastric mucosa and reducing the production of mucus (which plays a protective role in the gastric mucosa) or causing an increase. secrete gastric acid, facilitate gastric acid and pepsin to erode the mucosa. Drugs that cause stomach upset, if taken by injection, will damage the stomach by reducing the production of mucus or causing increased secretion of gastric acid. If taken orally, it will cause stomach ulcers by both mechanisms.
There are two common groups of drugs that have side effects causing stomach pain: corticosteroids and non-steroidal anti-inflammatory drugs.
2.1 Corticoid drugs Corticoid drugs include: Cortisol, Hydrocortisone, Prednisone, Prednisolone, Methylprednisolone, Betamethasone, Dexamethasone, Triamcinolone... have direct and indirect effects on increasing gastric acid and pepsin secretion, reducing prostaglandin synthesis. E1, E2, while reducing mucus production has a role in protecting the stomach lining. Corticosteroids have a side effect of causing stomach ulcers, which often occur with high doses or long-term use.
Nếu uống thuốc dạ dày không đầy đủ sẽ càng làm cho bệnh nghiêm trọng hơn
2.2 Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Non-steroidal anti-inflammatory drugs (NSAIDs) have the ability to inhibit COX1, reducing mucus production to protect the gastrointestinal mucosa. When the amount of mucus decreases, the gastric acid in the stomach will erode and destroy the stomach lining, leading to stomach ulcers. In particular, NSAIDs all have the common characteristic of being acidic derivatives with poor solubility. In the acidic environment of the stomach, it will be more difficult to dissolve, accumulate in the stomach longer, and directly irritate the mucosa and mucous membranes. cause peptic ulcer disease.
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely sold in the market such as:
Aspirin: The most commonly used salicylic acid derivative. Aspirin has a very good analgesic and antipyretic effect, so it is used by many people when they have high fever, toothache, headache, body aches, acute and chronic rheumatism. In addition, aspirin also has antiplatelet effects, inhibits the formation of blood clots, so it is widely used in myocardial ischemia. However, aspirin is a drug with a very high ability to cause peptic ulcers, even gastric perforation and gastrointestinal bleeding. Ibuprofen, often combined with paracetamol, is a component of many antipyretic analgesics such as antidol, alaxan, which acts to relieve pain quickly by inhibiting the synthesis and release of prostaglandins. However, Ibuprofen often causes side effects on the gastrointestinal tract (5-15% of people taking ibuprofen) such as: Nausea, vomiting, abdominal pain, bloating, more severe peptic ulcer, gastrointestinal bleeding . Diclofenac (diclofen, voltaren): Is an anti-inflammatory, analgesic commonly used to treat back pain, osteoarthritis, spondylosis, polyarthritis, ... Diclofenac is also one of the drugs that cause stomach pain. . Indomethacin: Has anti-inflammatory analgesic effect, is used to treat back pain, chronic arthritis, neuritis,... Abuse of this drug can cause peptic ulcer, enteritis, disorder. coagulation . Drugs meloxicam (mobic, camrox, M-cam), tenoxicam (tilcotil), piroxicam (fendene) are used in the treatment of osteoarthritis, ankylosing spondylitis, osteoarthritis... Although side effects are less frequent. However, there is still a high risk of causing peptic ulcers and gastrointestinal bleeding if abused or used in high doses for a long time.
In short, the use of stomach pain medication or common drugs if not according to the instructions and prescription of the doctor, it is very easy to encounter serious side effects.
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