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Cardorite medicine has the active ingredient Rosuvastatin and other excipients in a sufficient amount. This is a drug used in the treatment of primary hypercholesterolemia or mixed dyslipidemia effectively. However, the drug should not be used by pregnant and lactating women.
1. What is Cardorite?
Drug group: Cardorite belongs to the group of drugs for cardiovascular disease.
Dosage form: Film coated tablets.
Packing: Box of 3 blisters x 10 tablets
Ingredients: Active ingredient Rosuvastatin (in the form of Rosuvastatin calcium) 10mg and other excipients with a sufficient amount of 1 tablet.
1.1. Pharmacodynamics: Active ingredient Rosuvastatin is a selective and competitive inhibitor of HMG-CoA reductase. This is an enzyme that catalyzes the conversion of 3-hydroxy-3-methylglutaryl coenzyme A to mevalonate, a precursor of cholesterol.
1.2. Pharmacokinetics: Absorption: Peak plasma concentrations of Rosuvastatin are reached approximately 5 hours after oral administration. Absolute bioavailability is about 20%.
Distribution: Rosuvastatin is widely distributed in the liver, which is the major site of cholesterol synthesis and clearance of LDL-C. The volume of distribution of Rosuvastatin is approximately 134 L. Approximately 90% of rosuvastatin is bound to plasma proteins, mainly to albumin.
Metabolism capacity a: Active ingredient Rosuvastatin is rarely metabolised (about 10%). In vitro metabolism studies using human hepatocytes have shown that Rosuvastatin is a weak substrate for cytochrome P450 metabolism. CYP2C9 is the main enzyme involved in metabolism, other enzymes such as 2C19, 3A4 and 2D6 participate to a lesser extent. The major metabolites are N-desmethyl and lactone. Elimination: Approximately 90% of the therapeutic dose of Rosuvastatin is eliminated unchanged in the feces (including absorbed and unabsorbed active substances) and the remainder is excreted in the urine. About 5% is excreted unchanged in the urine. The mean plasma half-life is 19 hours. The half-life was not increased with higher therapeutic doses. The average plasma clearance of the active substance is about 50 liters/hour. Similar to other HMG-CoA reductase inhibitors, clearance of the active ingredient Rosuvastatin from the liver is related to the transmembrane transporter OATP-C. This transporter is important in the elimination of the active substance Rosuvastatin from the liver.
1.3. Mechanism of action: Rosuvastatin is a selective and competitive inhibitor of HMG-CoA reductase. The main site of action of Rosuvastatin is the liver, the target organ of cholesterol lowering. Rosuvastatin increases the number of LDL receptors on the cell surface in the liver, thereby increasing the absorption and catabolism of LDL and inhibits the synthesis of VLDL in the liver, thus has a role in reducing VLDL components. and LDL. Pharmacodynamic effects: Rosuvastatin reduces levels of LDL-cholesterol, total cholesterol and triglycerides and increases HDL-cholesterol.
2. Effects of Cardorite
2.1. Treatment of high blood cholesterol Treatment for adults and children over 6 years of age with primary hypercholesterolemia (type IIa including heterozygous familial hypercholesterolemia) or mixed dyslipidemia (type IIb). ) when the patient has not been able to reduce the cholesterol in the blood despite the use of a diet or other non-pharmacological treatments. Treatment of adults and children over 6 years of age with homozygous familial hypercholesterolemia when the patient fails to reduce cholesterol despite dieting or other lipid-lowering treatments. As an adjunct to the treatment of people with high serum triglyceride levels (type IV). Adjunctive therapy in combination with dietary modification in patients with primary dyslipidemia (type III). In combination with dietary modification for the treatment of people with advanced atherosclerosis. 2.2. Prevention of cardiovascular events Primary cardiovascular disease prevention in people without clinical signs or symptoms of coronary heart disease but at high risk for cardiovascular disease, used to reduce risk stroke, heart attack.
3. Usage and dosage of Cardorite
Before starting treatment with Cardorite, you need to follow a standard nutritional diet. The effect is to support the reduction of cholesterol in the blood and it is necessary to maintain this diet during treatment with the drug.
3.1. How to use Cardorite The drug is prepared in the form of film-coated tablets suitable for oral use. You must not break or crush the tablet, but swallow it with a sufficient amount of water. The drug is not affected by food, so you can use it at any time of the day, can be taken with meals, away from meals. 3.2. Therapeutic dose of Cardorite Therapeutic dose should be specific to treatment goals and individual response.
In adults
The therapeutic dose range of Rosuvastatin in adults is 5 - 40 mg. In the treatment of hypercholesterolemia, the recommended starting dose is 5 or 10 mg orally once a day. After 2-4 weeks of starting treatment, the doctor will order a test and monitor the blood lipid level to adjust the next dose. For those requiring primary prevention of cardiovascular disease, the therapeutic dose is 20 mg/day. In children over 6 years old
For people with heterozygous familial hypercholesterolemia, the doctor will prescribe 5 to 10 mg orally once a day, patients from 10 to 17 years old take a dose of 5 to 20 mg Drink 1 time/day. For patients with homozygous familial hypercholesterolemia, patients 7 to 17 years of age receive a dose of 20 mg orally once a day. The starting dose should only be 5 to 10 mg once a day depending on age, weight, and prior statin therapy. Elderly
The recommended starting dose for people over 70 years of age is 5mg. There is no need to adjust the dose according to age.
For patients with genetic polymorphisms
Certain genetic polymorphisms are known to increase the risk of exposure to the active ingredient Rosuvastatin, so a lower daily dose of Rosuvastatin is recommended.
For people with a history of myopathy
The recommended starting dose in people with predisposing factors for myopathy is 5 mg.
4. In case of missed dose or overdose of Cardorite
In case of missed dose: In case you miss a dose, skip that treatment dose and take your next dose the next day at the usual time you are still taking. You should absolutely take 2 doses at the same time to make up for the missed dose. If you frequently miss a dose, you should set an alarm or a dosing schedule to remind you to take your medication in full and on time each day.
In case of overdose: The dose of the active ingredient Rosuvastatin that can lead to an overdose is different for each person. In this case, you should immediately call the treating doctor or go to the nearest medical facility for symptomatic treatment and timely support measures. Liver function tests and CK levels then need to be monitored with laboratory tests.
5. Undesirable effects of the drug Cardorite
Like other drugs Cardorite 10 can also cause unwanted effects, but not everyone experiences these side effects and after a period of use, these side effects usually improve benevolent.
The most common side effects you may experience are: Fatigue, headache, dizziness, abdominal pain, nausea. When you experience these side effects, you can continue to use the medicine, but you should talk to your doctor about these side effects.
Occasionally, people using the drug can experience serious side effects, but the frequency is rarer. Side effects can include:
Muscle aches, weakness or cramps – this is a sign of muscle and kidney damage. Jaundice, yellow eyes – these are signs of liver-related problems. Severe stomach pain – this is a sign of problems related to the pancreas. Cough, shortness of breath, weight loss – these are signs of lung-related diseases. In cases of such undesirable effects, you should stop taking the drug and immediately notify the treating doctor to get an accurate decision.
When you experience some unwanted effects that are not too serious, you can handle them as follows:
If you feel nauseated: You should eat simple meals and give less spice and take medicine after meals . When this symptom persists for a few days and becomes more severe, contact your doctor. If you feel tired, dizzy: You should pause what you are doing, sit down or lie down to rest until you feel better. In this case you should not drive or operate machinery. Do not use preparations containing alcohol because it will make your condition worse. If you feel a headache: You should rest and drink plenty of water. Don't drink too much alcohol and maybe use pain relievers if you feel too much pain. If this symptom persists for more than a week or is more severe, contact your doctor. If constipated: You should add more foods rich in fiber such as fruits, vegetables, whole grains, drink more water, exercise more regularly. If you feel pain in the epigastrium or stomach: You should rest, relax and divide your meals into several small meals.
6. Interaction of Cardorite with other drugs
Some drugs when used together with Cardorite can reduce the effect or increase the toxicity of the drug. Therefore, you need to tell the treating doctor about all the medications you are taking, both prescription and over-the-counter medicines to avoid possible adverse effects.
Here are some Cardorite drug interactions with other drugs to watch out for:
Inhibitors of transport proteins Rosuvastatin is a substrate of several transport proteins including the hepatic absorption transporter OATP1B1 and BCRP transporter. Therefore, when Cardorite is used in combination with inhibitors of these transport proteins, plasma concentrations of Rosuvastatin are increased and the risk of muscle toxicity is increased.
Protease Inhibitors Concomitant use of Cardorite with protease inhibitors such as antivirals, HIV drugs or hepatitis C drugs may increase plasma concentrations of the active ingredient Rosuvastatin and increase the risk of muscle damage, which can even cause rhabdomyolysis, kidney failure, and be life-threatening.
Gemfibrozil and other lipid-lowering drugs Concomitant use of Cardorite with these drugs may increase the side effects of Rosuvastatin.
Antacid Antacids containing aluminum and magnesium hydroxide will reduce plasma concentrations of Rosuvastatin by about 50%. Therefore, when used at the same time, doctors usually prescribe Antacid treatment 2 hours after taking Rosuvastatin.
Erythromycin Concomitant use of these 2 drugs will reduce the AUC and Cmax of Rosuvastatin because the antibiotic Erythromycin may increase intestinal motility.
In addition, Rosuvastatin also affects some other medicines.
Vitamin K antagonists: Rosuvastatin should require a dose adjustment when used with vitamin K antagonists. Oral contraceptives or hormone replacement therapy: Concomitant use of Rosuvastatin with oral contraceptives cause adverse interactions, other methods of contraception should be considered.
7. Some notes when using Cardorite in treatment
7.1. Contraindications of the drug People with known hypersensitivity or hypersensitivity to the active ingredient Rosuvastatin or any of the excipients of the drug. Patients with active liver disease including persistent and unexplained elevations in serum transaminases. Patients with severe renal impairment with creatinine clearance < 30 ml/min. People with muscle disease. People who are taking Cyclosporin. Pregnant and lactating women, women can become pregnant if appropriate contraception is not used. 7.2. Some points to keep in mind when using Cardorite 10 Doctors will re-evaluate kidney function on a regular basis, especially when used at high doses. People on drug therapy should have liver enzyme and CK tests before starting treatment. During treatment, if you have muscle manifestations, you need to do a CK test to have appropriate interventions. People with hereditary problems of lactose intolerance should not use this medicine. In cases of suspected interstitial lung disease, statins should be discontinued. Cardorite medicine has the active ingredient Rosuvastatin and other excipients in sufficient quantities. This is a drug used in the treatment of primary hypercholesterolemia or mixed dyslipidemia effectively.
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