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Bravelle has Urofollitropin as the main ingredient, commonly used in the treatment of infertility in FSH-deficient women. However, when using Bravelle, patients may experience some unwanted effects such as blood clotting disorders, ectopic pregnancy,... Therefore, patients need to consult their doctor before use medicine.
1. What is Bravelle?
Bravelle is manufactured by Ferring GmbH - GERMANY. The main active ingredient of Bravelle is Urofollitropin.
Dosage form: Powder for injection.
Content: 75IU FSH/tube.
Packing form: Each medicine box includes 5 powder bottles and 5 solvent tubes or 10 powder vials and 10 solvent tubes.
2. What disease does Bravelle treat?
Bravelle is a purified form of a hormone called follicle-stimulating hormone (FSH). This hormone is important in the development of the follicles produced by the ovaries.
Bravelle is used together with other medicines to treat infertility in women with FSH deficiency. This medicine is also used to help the ovaries produce more eggs for use during IVF.
Bravelle alone will not cause shedding. Therefore, it is necessary to combine with other drugs to stimulate ovulation.
3. Indications and contraindications of Bravelle
Bravelle is usually indicated in the following cases:
Stimulation of ovulation in female patients who do not ovulate and do not respond to Clomiphene citrate. Stimulation of the ovaries to create primary follicles to support other assisted reproductive techniques. Absolutely do not use Bravelle for the following cases:
Primary ovarian failure. Cancer of the ovary, breast, uterus. Untreated or uncontrolled thyroid disorders. Untreated or uncontrolled adrenal gland disorders. Infertility is not caused by not ovulating. Unusual vaginal bleeding that has not been treated. Endometrial cancer . Tumor of the pituitary gland. Pregnant.
4. Dosage and how to take Bravelle
To use Bravelle safely and effectively, to avoid causing adverse health effects, you need to follow your doctor's instructions or the manufacturer's instruction sheet on dosage, route of administration, and interval. between medications. Do not arbitrarily adjust the dose, route of administration or dosing interval. Also, do not give Bravelle to others to use when they have the same symptoms as you.
Dosage:
Usual adult dose to stimulate ovulation: 150UI/day x 5 days. Maximum dose: 450UI/day. Dosage in assisted reproduction: 225UI/day x 5 days, injected subcutaneously. Maximum dose: 450UI/day. If used with menotropins, the total combined dose should not exceed 225 UI/day (150 UI Urofollitropin and 75 UI Menotropin, or 75 UI Urofollitropin and 150 UI Menotropin). Route of administration: Subcutaneous injection, intramuscular injection. Do not self-inject this medication if you do not know how to inject and dispose of used needles and syringes properly.
Note:
Do not use if the medicine is cloudy, changes color or has particles in it. After injection, throw away the reconstituted portion of the drug that is not used immediately. Use disposable needles and syringes and follow regulations regarding the disposal of used needles and syringes. Use sharps containers and keep them out of reach of children and pets. To be sure the medication is working, you'll need regular blood tests and ultrasounds. In addition, you may also need to record your body temperature on a daily chart. What to do in case of an overdose of Bravelle?
In case of overdose, it is necessary to bring the patient to the nearest medical center for timely emergency treatment. Family members should bring all medications the patient has taken (prescription, non-prescription, herbal products, vitamins, minerals, ...) and related documents to support the diagnosis Fast, timely.
5. Undesirable effects
Some women using Bravelle develop a condition called ovarian hyperstimulation syndrome (OHSS), especially after the first treatment. OHSS can be a life-threatening condition. So stop using Bravelle, do not have sex and call your doctor at once if you have any of the following symptoms of OHSS:
Abdominal pain, bloating. Nausea, vomiting, diarrhea. Rapid weight gain, especially in the face and abdomen. Urinating little or no urine. Pain on breathing, tachycardia, shortness of breath (especially when lying down). Also go to the nearest emergency facility immediately if you have signs of an allergy, stroke or blood clot, such as:
Allergic manifestations: hives, swelling of the face, lips, tongue, swelling of the throat, difficulty breathing ,... Sudden severe headache, numbness or weakness (especially on one side of the body). Stutter. Problems with vision or balance. Sudden cough, coughing up blood, chest pain, wheezing, rapid breathing. Swelling, heat, redness, pain in one or both legs. Common side effects of Bravelle may include:
Stomach cramps or bloating. Headache. Nausea. Shortness of breath. Hot flashes. Mild pelvic pain.
6. Drug interactions
When treating with many drugs, there may be interactions that affect the bioavailability, effect, and even increase the toxicity of the drug. Therefore, to ensure safety during the use of Bravelle, you need to list and inform your doctor about all the medicines you are using, including injections, oral, topical, vitamins-minerals, products. herbal products.
Drugs known to interact with Bravelle are Ganirelix. In addition, beer and other alcoholic beverages can interact with the ingredients of Bravelle. Therefore, it is important to discuss this with your doctor.
7. Some notes when using Bravelle
Use of Bravelle during pregnancy: Although Bravelle can increase your chances of getting pregnant, it can also harm an unborn baby or birth defects. Therefore, do not use Bravelle if you are pregnant. In addition, you need to contact your doctor immediately if you become pregnant while taking this medicine.
Use of Bravelle during breast-feeding: There is not enough research data on whether Bravelle passes into breast milk or harms a nursing infant. Therefore, you should not breast-feed while using Bravelle.
In addition, the male partner's fertility should be tested prior to treatment with Bravelle.
To make sure Bravelle is safe to use, tell your doctor if you have the following conditions:
Asthma. History of gastric surgery. History of ovarian cyst or ovarian torsion. Having risk factors for blood clots (such as diabetes, smoking, heart disease, coronary heart disease, being overweight, family history of coronary heart disease). Using Bravelle can increase the likelihood of multiple pregnancies (twins, triplets, quadruplets...), dangerous risks for mother and baby. Therefore, it is important to follow your doctor's instructions about any special care needed during pregnancy. Bravelle may also increase your risk of tubal pregnancy, miscarriage, stillbirth, premature labor, birth defects, or fever after delivery if you become pregnant after treatment with Bravelle. Also, Bravelle may increase your risk of developing uterine cancer, so tell your doctor right away if you have unusual vaginal bleeding.
8. Preservation of drugs
Store Bravelle in a cool, dry place at room temperature. Avoid direct light on the medicine, do not freeze Bravelle. Keep Bravelle out of reach of children and pets. Above is information about uses, dosage and notes when using Bravelle. If you need more information about the drug, the patient should contact the doctor/pharmacist for advice.
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