Anectin drug effects

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1. What is Anectine?

Anectine has the active ingredient succinylcholine chloride, which is prepared for intravenous injection.
Anectine Injection is a sterile solution for intravenous administration in which each mL contains 20 mg of active succinylcholine chloride.
Anectine (Succinylcholine) is a muscle relaxant, after entering the body, the drug combines with cholinergic receptors to create depolarization, causing neuromuscular transmission to be inhibited, making the patient paralysed. softens rapidly less than 1 minute after intravenous administration and with a single administration prolongs this muscle relaxant effect by about 4 to 6 minutes.
Although when taking Succinylcholine there is no direct effect on the heart muscle. But succinylcholine stimulates both autonomic ganglia and muscarinic receptors which can cause changes in heart rate, including cardiac arrest, which can also be caused by vagal stimulation during surgery, or by increased potassium. blood, especially in pediatric patients. Succinylcholine also causes an increase in intraocular pressure immediately after injection.

2. Uses of the drug Anectine

Anectine is indicated as an adjunct to general anesthesia, to facilitate intubation and to help relax muscles during surgery or during mechanical ventilation.
Note that Anectine should not be used in the following cases:
People with a personal or family history of malignant hyperthermia, muscle disease. People with hypersensitivity to the drug. The drug is also contraindicated in patients after the acute phase of trauma following major burns, multiple trauma, loss of musculoskeletal function or upper motor nerve injury, because when taking succinylcholine is used for Such people can lead to severe hyperkalemia that can lead to cardiac arrest.

3. Dosage and Administration of Anectine

Drugs are administered intravenously, you will be given this medication by medical staff. Dosage of Anectine should be individualized, carefully determined. Here are the reference dosages:
For short surgical procedures
The average dose required to induce neuromuscular blockade, for intubation conditions is 0.6 mg/kg Anectine injected vein. The optimal dose will vary from person to person: Average is 0.3 to 1.1 mg/kg for adults. After administration of doses in this range, neuromuscular blockade develops over a period of several minutes. However, as very large doses can lead to more prolonged blockade, specific studies are needed before appropriate dosages can be given. For long surgical procedures
The dose depends on the duration of the surgery and the need for muscle relaxation. The average rate for an adult is about 2.5 to 4.3 mg per minute.
Children:
For emergency intubation or immediate need for airway protection, can be used in young children. But the dose is carefully calculated by weight. It should be noted that in rare cases intravenous administration of succinylcholine to neonates and pediatric patients may result in malignant ventricular arrhythmias and cardiac arrest secondary to acute rhabdomyolysis with hyperkalemia. In such situations, an underlying myopathy should be suspected.
Intravenous use of succinylcholine in neonates or pediatric patients may result in profound bradycardia or, rarely, loss of heart rate. As in adults, the incidence of bradycardia was higher in pediatric patients after a second dose of succinylcholine.
Overdose:
An overdose of Anectine can lead to neuromuscular blockade beyond the time required for surgery and anesthesia. Causes excessive muscle relaxation or stops breathing.

4. Possible side effects when taking Anectine

Anectine side effects are mainly caused by its excessive pharmacological effects, including:
Succinylcholine causes deep muscle relaxation leading to respiratory depression to the point of apnea; Other adverse reactions have been reported, including: cardiac arrest, malignant hyperthermia, arrhythmias, bradycardia or tachycardia, hypertension or hypotension, hyperkalemia, respiratory depression or causes prolonged apnea, glaucoma, muscle spasticity, postoperative myalgia, possible rhabdomyolysis, acute renal failure, profuse salivation and rash. Anaphylaxis: Serious anaphylactoid reactions to neuromuscular blocking agents, including Anectine, have been reported. These reactions can be life-threatening and fatal. Because of the potential severity of these reactions, necessary precautions should be taken, such as being ready for appropriate emergency treatment immediately. Hyperkalemia: May be encountered and cause serious arrhythmias or cardiac arrest due to hyperkalemia. Malignant Hyperthermia: The use of Succinylcholine has been associated with the acute onset of malignant hyperthermia, a potentially fatal hypermetabolic state. The risk of developing malignant hyperthermia following administration of succinylcholine is increased with concomitant administration of volatile anesthetics.

5. Things to keep in mind when taking Anectine

In both adults and pediatric patients, the incidence of bradycardia, which can progress to asystole, was higher after a second dose of succinylcholine. The incidence and severity of bradycardia in pediatric patients is higher than in adults. Pretreatment with anticholinergics such as atropine may reduce the occurrence of arrhythmias.
Succinylcholine should be used with caution in patients with fractures or muscle spasms because initial muscle spasticity may exacerbate injury.
As allergic cross-reactions with other drugs have been reported in this class, patients should be informed of previous anaphylactic reactions to any other neuromuscular blocking agent.
Pregnant and lactating women: Because the risk of effects is unknown, use only when absolutely necessary. Drug interactions: Drugs that may enhance the neuromuscular blocking activity of succinylcholine such as promazine, oxytocin, aprotinin, some non-penicillin antibiotics, β-adrenergic blockers, procainamide, lidocaine, trimethaphan, lithium carbonate, magnesium salts, quinine, chloroquine, diethylether, desflurane, metoclopramide and terbutaline. The neuromuscular blocking effect of succinylcholine may be enhanced by chronic oral contraceptives, glucocorticoids or some monoamine oxidase inhibitors...
Anectine is a drug that is taken when prescribed by a doctor. You should ask your doctor about any risks with taking the medication and talk to your doctor about your medical history to make sure it's safe to take.

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