Uses of the drug Vadol

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Vadol belongs to the group of pain relievers and fever reducers thanks to the main ingredient being paracetamol. Let's learn about the use of Vadol and the notes when using

1. Uses of the drug Vadol

Thanks to the paracetamol component, Vadol is proven effective and prescribed in the following cases:
Fast pain relief, helping patients feel more comfortable with headaches, pain after tooth extraction, menstrual cramps , sore throat, joint pain, sinusitis .... Vadol helps reduce fever quickly, thus limiting prolonged fatigue, dehydration and convulsions when high fever in children.

2. Contraindications of the drug Vadol

In order to avoid dangerous complications, absolutely do not use Vadol for the following cases:
All cases of hypersensitivity to any ingredient of the drug are not prescribed. Children under 6 years of age should not arbitrarily use the drug without instructions or prescription from a doctor. Patients with anemia, heart disease, liver disease should not use the drug Patients with glucose - 6 - phosphate dehydrogenase deficiency

2. Usage and dosage

2.1. How to take Vadol is used orally. Experts recommend that the time between doses should be at least 4 hours apart and the dose should not exceed 4g/day.
2.2. Dosage of vadol 325 or vadol extra 500mg should be taken according to the doctor's prescription. The specific dose will depend on the condition and the progression of the disease. Here is the suggested dosage for reference only:
2.2.1. Adults and children 12 years and older Take 500mg to 1g paracetamol (1-2 tablets/time), every 4-6 hours if needed. Maximum daily dose: 4000 mg. No overdose specified. Do not take with other medicines containing paracetamol. 2.2.2 Children 6 to 11 years of age Apply a dose of 250-500 mg every 4 to 6 hours as needed. Maximum daily dose: 60 mg/kg body weight in divided doses, each time 10-15 mg/kg body weight used for 24 hours. Maximum duration of taking the drug without consulting a doctor: 3 days. 2.3. Missed dose and treatment If you forget a dose of Vadol, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your next dose at the scheduled time. Note that double the prescribed dose should not be taken.
2.4. Overdose and treatment Vadol overdose, also known as Paracetamol overdose, can be caused by one or more of the following reasons:
Due to a single toxic dose Abuse of large doses of Paracetamol, possibly 7.5 - 10g per day , in 1-2 days. Using Vadol for a long time These cases can cause liver necrosis, even death. Some symptoms of patients may experience when overdose Paracetamol such as nausea, vomiting, abdominal pain, cyanosis symptoms of skin, mucous membranes and nails.
In this case, the patient needs active supportive treatment. First, the doctor will prescribe gastric lavage, which is most effective when done within 4 hours of ingestion.
Vadol poisoning has the main antidote is using Sulfhydryl compounds. N-acetylcysteine. Ensure that the patient is given oral or intravenous infusion within less than 36 hours of taking Paracetamol. When giving orally, dilute the N - acetylcysteine ​​solution with water or a non-alcoholic beverage to obtain a 5% solution and must be drunk within 1 hour after mixing. Give oral N - acetylcysteine ​​with the first dose of 140 mg/kg body weight, then give another 17 doses, each dose of 70 mg/kg body weight every 4 hours.

3. Possible side effects when using Vadol

Some side effects may be seen in a small number of patients such as: skin rash, vomiting, nausea, pancytopenia, leukopenia, kidney disease,... The reactions are quite rare after taking the drug. Vadol as: hypersensitivity reactions. May cause liver failure (due to hepatocellular destruction) when used in high doses, for a long time.

4. Drug interactions

Before using Vadol, patients should note some drug interactions as follows:
Long-term intake of high doses of Paracetamol slightly increases the anticoagulant effect of Coumarin and Indandion derivatives. Attention should be paid to the potential for severe hypothermia in patients receiving concomitant phenothiazines and antipyretic therapy. Anticonvulsants (Phenytoin, Barbiturates, Carbamazepine) induce enzymes in the liver microsomes, which may increase the hepatotoxicity of Paracetamol by increasing the metabolism of the drug into substances that are toxic to the liver. Concomitant use of Isoniazid with Paracetamol may lead to an increased risk of hepatotoxicity.

5. Be careful when using Vadol

Must be used with caution in people with liver failure, kidney failure and alcoholism. Thrombocytopenia, leukopenia, and pancytopenia have occurred with the use of p-aminophenol derivatives, especially with prolonged use of large doses. Neutropenia and thrombocytopenic purpura have occurred with paracetamol. Persons with phenylketonuria (ie, deficiency of the gene that determines the status of phenylalanine hydroxylase) and those who must limit their intake of phenylalanine should be warned that some paracetamol preparations containing aspartame will be metabolized in the stomach stomach - intestines into phenylalanine after oral administration. Heavy drinking can increase the hepatotoxicity of paracetamol, so alcohol should be avoided or limited. Patients may experience some diseases when using the drug such as Stevens-Johnson syndrome (SJS), toxic skin necrosis syndrome (TEN) or Lyell's syndrome, acute generalized exanthematous pustulosis syndrome. (AGEP). Use caution when driving and operating machinery, because the drug can cause drowsiness, fatigue, loss of concentration... Pregnant women should avoid using antibiotics for 3 months. early pregnancy. The safety of paracetamol during pregnancy has not been established. However, please consult your doctor when pregnant women need to use the drug. Hopefully the above information has helped you answer the question "What are the uses of Vadol?". However, in order to limit the side effects and risks when taking the drug, the patient should visit the doctor and take the drug exactly as prescribed by the doctor.

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