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Nospa medicine 40mg belongs to the group of antispasmodic drugs with the main ingredient is Drotaverine hydrochloride 40mg content. The effect of Nospa 40mg is to reduce spasms of smooth muscles in the gastrointestinal tract, urinary tract, reproductive system and blood vessels. Learn the basic information of Nospa 40mg drug such as ingredients, uses, doses and side effects that will give patients the best treatment effect.
1. What is Nospa 40mg?
Nospa medicine 40mg is made in the form of tablets or solution for injection, with the main ingredients including:
Active ingredients: Drotaverine hydrochloride 40 mg. Excipients: Tablets: Lactose monohydrate, Talc, Corn starch, Magnesium stearate. Sufficient tube of 2 ml solution. Solution for injection: Sodium metabisulfite, Distilled water for injection, Alcohol, Carbon dioxide. Just enough for 1 tablet of 40 mg. Pharmacodynamics
In the body, the enzyme Phosphodiesterase (PDE) IV has the main effect of inhibiting the contractility of smooth muscle, and Phosphodiesterase (PDE) III hydrolyzes cAMP in the myocardium and the muscle in the blood vessels.
Active ingredient Drotaverine is a derivative of Isoquinoline, which selectively inhibits PDE IV, not inhibiting enzymes of the same group as PDE III. Therefore, Drotaverine can be effectively applied in the treatment of hypermotility disorders and diseases associated with gastrointestinal, urinary or genitourinary or vascular smooth muscle spasms, and without adverse effects. undesirable effects on the myocardium.
The effect of Drotaverine is independent of the distribution of the autonomic nervous system on the muscles of the gastrointestinal tract, biliary tract, urinary system, genitourinary system and blood vessels.
2. What are the effects of Nospa 40mg?
Nospa medicine 40mg is indicated for the treatment of the following cases:
Reduce biliary smooth muscle spasm encountered in gallstones, peri-gall bladder inflammation, cholecystitis, cholangitis, pancreatic ball. Treatment of renal colic pain due to smooth muscle spasm encountered in kidney stones, ureteral stones, pyelonephritis, pyelonephritis, cystitis, bladder spasms. Support the treatment of gastrointestinal smooth muscle spasms such as spasms in peptic ulcer disease, spasms of the stomach, pylorus, colon spasms, constipation and other forms of abdominal distention caused by colon syndrome irritable bowel, enteritis, and colitis. Reducing smooth muscle spasms in obstetric and gynecological diseases such as abdominal pain in threatened miscarriage, dysmenorrhea...
3. Contraindications of Nospa 40mg
Nospa 40mg drug is contraindicated in the following cases:
Hypersensitivity to any ingredient of Nospa 40mg drug. History of allergy to drugs containing Drotaverine. People with impaired liver function, severe kidney function. People with severe heart failure with low ejection fraction. Cardiovascular conduction disturbances such as first degree atrial block II-III. Children < 1 year old.
4. Dosage and how to use Nospa 40mg
In each dosage form, there will be different ways to use the drug. Specifically:
4.1. Injections Adults
Usual dose: Intramuscular injection 1-2 ampoules (40mg)/time x 1-3 times/day. Dose to relieve gastrointestinal or urinary colic: Intravenous injection 1-2 ampoules (40-80mg)/time x 1 time/day. Children : Injection is not recommended.
4.2. Tablets Adults: Dose: Take 1-2 tablets (40 - 80mg)/time x 3 times/day.
Children 1 - 6 years old: Dose: Take 1⁄2 - 1 tablet (20-40mg)/time x 2 - 3 times/day.
Children > 6 years old: Dosage: Take 1 tablet (40 mg)/time x 2-3 times/day.
Note: The intravenous route is only used in acute pain with severe severity. The drug should be mixed with distilled water before injection and injected at a slow rate. Before use, consult a doctor.
5. Side effects when using Nospa 40mg
Side effects encountered when using Nospa 40mg:
Using Nospa 40mg in high doses or for a long time can cause rare side effects such as:
Digestive disorders: Nausea, vomiting, constipation or diarrhea. diarrhea. Nervous disorders: Headache, dizziness, insomnia. Cardiovascular disorders: Hypotension, palpitations. Immune disorders: Allergic hypersensitivity such as urticaria, angioedema, erythema, pruritus. Severe can lead to anaphylaxis. When experiencing the above symptoms or other undesirable symptoms after using Nospa 40mg, the patient should immediately notify the treating doctor or go to the nearest medical facility for timely treatment.
6. Note the use of Nospa 40mg drug in the subjects
Caution should be taken when using Nospa 40mg in the following cases: People with current or history of hypotension, people with rare disorders such as Galactose intolerance, Glucose-Galactose malabsorption, or Lactase deficiency caused by The drug is in tablet form and the excipient is Lactose. Pregnancy: Studies have shown that Drotaverine does not increase the risk of fetal abnormalities in women who are pregnant. Clinically, it is still possible to use Nospa 40mg on this subject but must be approved by a doctor specializing in obstetrics and gynecology. Lactation: There are limited data on the effects of Drotaverine in this population, so Nospa 40mg should not be used in this population. Drivers or machine operators need to be careful when using Nospa 40mg, because they may experience side effects such as headache, dizziness or insomnia.
7. Nospa 40mg . drug interactions
Nospa 40mg reduces the effect of Levodopa in the treatment of symptoms in Parkinson's disease. In addition, to avoid drug interactions, patients need to list the herbs, drugs, and dietary supplements they are using.
Above is an overview of ingredients, uses, dosages and notes when using Nospa 40mg. In order to bring about the best treatment effect, patients should carefully read the instructions for use on the packaging of Nospa 40mg product and strictly follow the instructions of the treating doctor.
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