Uses of Hitop 100mg

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1. What is Hitop 100mg?

Drug Hitop 100mg is a prescription drug, belongs to the group of psychoactive drugs. Hitop 100mg has the main active ingredient Topiramate and excipients such as:
Tablettose 80 Mesh; Avicel pH 102; Pregelatinized starch; Sodium starch glycolate; Talcum powder; Titanium Dioxide; Color Orage red;

2. Uses of Hitop 100mg

The ingredient Topiramate contained in Hitop 100mg is anti-epileptic, classified as a sulphonamide-substituted monosacchairid. Topiramate has an antiepileptic effect through three properties:
Action potentials repeated by prolonged depolarization of neurons are blocked by topiramate in a temporal pattern, resulting in a sodium channel blocking action. status; Increased GABA activity at some GABA receptors; Weakly inhibits the excitatory effects of KAINI/AMPA glytamate receptor subtype. In addition, Topiramate also has the ability to inhibit some isozymes of carbonic anhydrase.
Hitop medicine 100mg is indicated for adults and children over 4 years old with:
Partial-onset epilepsy with or without secondary generalized seizures; Epilepsy with Lennox-Gastaut syndrome; Generalized epilepsy with tonic-clonic seizures; Not responding well to first-line antiepileptic therapy. Hitop medicine 100mg is not used for subjects who are hypersensitive or allergic to any of the ingredients in the drug.

3. Dosage – how to use Hitop 100mg

Hitop medicine 100mg for oral administration according to the instructions prescribed by the doctor. Dosage is usually started with a low dose, then titrated up to the target dose.
Treatment with Hitop 100mg should be started at a low dose, then increased to the target dose. Hitop medicine 100mg can be taken at any time according to the instructions of medical staff.
3.1. Hitop 100mg Dosage in Adults Treatment with Hitop 100mg begins with a low dose of 25-50mg every night/week. Use weekly, increase dose to 25-50mg/day x 2 times. The dose may be adjusted to achieve good seizure control.
Usually the total daily dose is from 200-400mg x 2 times orally. The maximum daily dose should not exceed 800mg
3.2. Dosage of Hitop 100mg in children > 4 years of age Hitop 100mg is recommended to be used at a dose of 5-9 mg/kg body weight x 2 times/day. Adjust dose to 25 mg/day nightly for the first week, possibly increasing weekly or 2 weeks to 1 to 3 mg.kg body weight/day x 2 times orally to achieve seizure control.

4. Warning – note when using Hitop 100mg

Hitop 100mg drug is warned to gradually reduce the dose to reduce the frequency of seizures. Some trials reduced the dose at 100 mg/day per week. For patients with moderate to severe renal impairment, it may take 10 to 15 days to reach stable concentrations compared to 4 to 8 days for people with good renal function.
Hitop 100mg can be increased in dose for optimal seizure control and avoidance of side effects. In addition, when taking Hitop 100mg, there may also be a risk of kidney stone formation.
In subjects with impaired liver function, caution should also be exercised because Topiramate clearance may be reduced.
In addition, when using the drug Hitop 100mg also need to be careful because it also causes:
Metabolic acid; Decreased sweating and increased body temperature; Psychosis; Suicidal intention and behavior; The warnings given by the manufacturer are intended to avoid the possible side effects and risks when using Hitop 100mg.

5. Side effects Hitop 100mg

Hitop medicine 100mg should be used with caution, because it can cause unpredictable side effects. Some side effects are warned by the manufacturer when using Hitop 100mg including:
Drowsiness; Tired ; Stress ; Psychomotor slowness; Dizziness; Anorexia, weight loss; Difficulty concentrating ; Other side effects that are less mentioned are agitation, emotional disturbances, psychosis, depression, hallucinations... In children, the most common side effects when using Hitop 100mg are sadness. sleep, loss of appetite, difficulty concentrating, purpura...
The frequency and side effects of these may vary from person to person, when using Hitop 100mg you need to monitor and inform your doctor to be more specific advice.

6. Interactions when taking Hitop 100mg

Drug Hitop 100mg may cause interactions when used with some other drugs such as:
Ingredients have the same effect as Topiramate; Birth control pills; Use with Hitop 100mg with Digoxin, Hydrocholorothiazide, Metformin, Glyburide; Some other drugs such as antidepressants, alcohol,...; Drug interactions Hitop 100mg is quite complicated, so it should be used with caution when used with other drugs.

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