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Crysvita is a monoclonal antibody used in the treatment of an inherited disease that causes low blood phosphorus levels. Treatment helps stabilize blood phosphorus levels and reduce the risk of disease caused by hypophosphatemia.1. What are the uses of Crysvita?
Crysvita drug has the main ingredient is Burosumab 10mg / 1ml, prepared for injection.
Crysvita is a monoclonal antibody that targets and blocks the action of a blood protein called FGF23. In an inherited condition that causes hypophosphataemia, low levels of phosphate in the blood are found to be caused by abnormally high levels of the protein FGF23, which causes the kidneys to stop reabsorbing phosphate into the bloodstream.
Blocking the protein FGF23 allows the kidneys to restore and maintain phosphate levels within normal values. Phosphate is very important for the strength of bones and teeth. Low phosphate levels can lead to bone deformities and growth problems.
Crysvita is used to normalize phosphate levels in adults and children who are at least 1 year old and have X-linked hypophosphatemia.
2. How to use Crysvita
How to take:
Before taking this medicine you will have blood tests done to make sure that you do not have other conditions that would prevent you from using Crysvita safely. At least 1 week before you start using it for the first time, stop taking oral medications that contain ingredients such as phosphate and vitamin D. Crysvita is administered by subcutaneous injection. Usually every 2 weeks in children and every 4 weeks in adults. During the injection you will be injected by the medical staff. Dosage: Crysvita dosage is based on weight in children. Children's dose needs may change if they gain or lose weight. Or when the condition does not respond adequately
For children aged 1 year to under 18 years): For patients weighing less than 10kg, the recommended starting dose is 1mg/kg body weight, rounded to the nearest 1mg, use twice a week. For patients weighing 10 kg or more, the recommended starting dose is 0.8 mg/kg body weight, administered every two weeks. The minimum starting dose is 10mg up to the maximum dose of 90mg. For adults over 18 years: Use at the recommended adult dose of 1 mg/kg body weight, rounded to 10 mg to a maximum dose of 90 mg, administered every four weeks. Pediatric patients with tumour-induced osteomalacia (2 years to less than 18 years): The recommended starting dose for this child is 0.4 mg/kg body weight, administered every 2 weeks to a maximum dose of 2 mg/kg not exceeding 180 mg. use every 2 weeks. After taking the drug, re-evaluate the fasting blood phosphate level every 4 weeks. If stable, maintain therapeutic dose. If not, the dose should be increased or decreased depending on the case.
3. Contraindications to the drug Crysvita
You should not use Crysvita if you have the following conditions:
Have severe or end-stage kidney disease; Do not take it if you are currently taking oral phosphate or vitamin D supplements. These drugs should be discontinued at least 2 weeks prior to treatment. Do not use if you are sensitive to Burosumab or any of its ingredients. Crysvita is not recommended for use by anyone under the age of 1.
4. Undesirable effects of Crysvita
When taking the drug a person may experience unwanted effects that can range from mild to severe. Undesirable effects that you may experience include:
Severe allergic reactions include: Hives ; shortness of breath; severe abdominal pain; facial swelling, swelling of the lips, tongue, or throat; much dizziness. When you experience an allergic reaction you need urgent treatment. Common side effects of Crysvita may include: Headache, dizziness; pain in your arms, legs, or back; vomiting, constipation; having a restless feeling in your legs; fever; tooth infection; a decrease in the level of vitamin D in the blood; excessive phosphorus levels; or pain, redness, itching, swelling, bruising, or a hard lump at the injection site. This is not a complete list of side effects and other possible side effects. Tell your doctor about any unwanted effects you experience while taking Crysvita
5. Things to keep in mind when using Crysvita
Medicines are taken under the direction of a doctor, tell your doctor if you are allergic to the drug or have a medical condition such as kidney disease or restless legs syndrome. You need to have regular medical check-ups while taking the medicine. Even if you don't have any symptoms, these tests can help your doctor determine if this medicine is working. It is not known whether Crysvita will harm an unborn baby. Tell your doctor if you are pregnant or if you become pregnant while using Crysvita. This medicine may not be safe to use while breastfeeding. Ask your doctor about any risks that a breastfed baby may face so that the benefits and risks can be weighed carefully. When taking drugs, drug interactions can occur. Be sure to tell your doctor about all the medications you take, including prescription and over-the-counter medicines, including vitamins and herbal products. Crysvita drug is used in the treatment of hypophosphatemia, when using you need to ensure that you follow the instructions for use and monitor after use to ensure safe and effective use of the drug.
