How is Von Willebrand disease treated?

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Von Willebrand is a blood clotting disorder where there is normally a protein in the blood that helps control bleeding. People with von Willebrand disease don't have enough of this protein, or have it but don't work properly, which slows blood clotting, so bleeding takes longer to stop. So how is von Willebrand disease treated?

1.Outline of von Willebrand disease Von Willebrand is a glycoprotein synthesized mainly in endothelial cells. The functions of this glycoprotein are:
As a mediator for platelet adhesion to the collagen layer of the endothelium. Stimulates platelet aggregation. As the carrier protein of factor VIII, which helps keep factor VIII stable von Willebrand's disease is a blood clotting disorder where either a lack of a protein in the blood that helps control bleeding or a protein that doesn't work properly leads to slow blood clotting. , causing prolonged bleeding.
2. Causes of von Willebrand disease von Willebrand disease can be inherited, both parents carry the disease gene to their children. However, the degree of bleeding among patients who are family members varies widely.
In fact, there are cases of patients with the disease but no history of bleeding in the family, it is thought that von Willebrand disease occurs due to mutations in the gene of von Willebrand before the child was born.
Von Willebrand disease has many forms, but all are caused by proteins of von Willebrand factor.
When a blood vessel breaks and bleeds, von Willebrand factor plays a role in helping platelets stick together and form a clot to stop bleeding. When there is a deficiency or there are von Willebrand factors that do not work properly, bleeding will take a long time to stop.
Blood type also plays a role in von Willebrand disease, people with blood type O often have lower levels of von Willebrand factor than people with blood type A, B or AB. Therefore, patients with type O blood type von Willebrand have more severe bleeding.

3. Diagnosis of von Willebrand's disease To know if you have the disease or not, patients should pay attention to the following symptoms for timely detection and medical facilities as soon as possible. Doctors will rely on symptoms and clinical signs to diagnose the disease.
3.1 Clinical of the disease Prolonged bleeding time (usually bleeding from the nose, teeth, mouth), bleeding after surgery or after tooth extraction. Bleeding under the skin. 3.2 Laboratory Tests Complete blood count: HBG, RBC, PLT are normal (unless there is anemia due to blood loss and low platelet count in von Willebrand type 2B). Test for prolonged bleeding time. Tests show that the clot does not contract or does not contract completely. Stop platelet aggregation with reduced ristocetin. APTT may be prolonged. Factor VIII is normal or decreased. Quantification of concentrations and activities of von Willebrand factor, other clotting proteins. 4. The von Willebrand cure For von Willebrand disease, your doctor will likely recommend one or more of the following treatments, to increase the von Willebrand factor and increase blood clotting in women to control bleeding. Heavy bleeding during menstruation:
Treatment is usually with synthetic drugs such as desmopressin, a concentrated factor preparation containing von Willebrand factor, drugs that help control bleeding. Taking transamin or colloidal fibrin can control bleeding in the lining of the nose, mouth, intestines, or uterus. Hormone therapy, such as oral contraceptives, increases levels of von Willebrand factor, VIII, and helps control menstrual bleeding. moon. Transfusion of red blood cells Take iron tablets (when anemia is present).

5. Doctor's Advice Patients with von Willebrand should always carry information about: diagnosis, treatments, and the name and phone number of the doctor or hospital who treated him or her, so that if in any of the cases, the doctor or hospital that treated him or her If necessary, this information will help medical staff pay attention to the patient's bleeding disease.
When traveling, on business or away..., the patient should find out the address and phone number of the hospital treating blood clotting disorders at the destination and remember to bring the medical examination book. Every time you go to the doctor, you need to tell the doctor about your bleeding disease before taking any medicine.
Patients should develop a regular daily exercise regimen to keep muscles and joints strong. Eating a well-balanced diet and paying attention to vitamin C supplements will be very helpful for the patient's health.
Treatments for von Willebrand's disease can have side effects, so von Willebrand patients should talk to their doctor about possible side effects.
Von Willebrand is inherently a complex disease, so patients should not be subjective and need to follow the doctor's instructions in treatment to have the best improvement in terms of health. Vinmec International General Hospital is a high-quality medical examination address, meeting international standards with a team of qualified doctors combined with a system of modern equipment and machinery. Therefore, when there are any health problems, customers can go to the hospital to be examined and consulted by specialists and specialists.

Besides, in order to help customers always control their health well, Vinmec Hospital has developed a general health checkup package for all subjects and ages. The examination helps the doctor give advice and advice on the diet, sleep, and activities that are most suitable for each person's condition.