Uses of Entacron 25

Entacron is a drug used in diseases such as kidney disease, liver disease, heart disease causing edema, ascites and also used in combination in hypertension. So what is the drug Entacron 25, how does it work and how to use it?

The main ingredient of Entacron 25 is Spironolactone 25mg, which is prepared in the form of film-coated tablets.
Spironolactone is a potassium-sparing diuretic, which is a competitive antagonist of aldosterone. Spironolactone drug acts on the distal renal tubule, inhibits the effect of water and Na + retention, inhibits the effect of increasing the elimination of K + of aldosterone. Spironolactone not only increases the excretion of Na+ and Cl-, reducing the elimination of K+, but it also inhibits the excretion of H+ in the urine. The result of diuresis is to reduce water and Na+ retention in the body, which in turn also lowers blood pressure.
The drug is used in the following cases:
Cases with primary or secondary hyperaldosteronism. In combination with other diuretics that have the effect of removing K + blood to treat edema due to heart failure, edema due to congestive heart failure, edema due to cirrhosis of the liver with ascites. Nephrotic syndrome: if treatment measures or measures to limit the use of water and salt or use other diuretics but do not achieve the desired effect. Primary hypertension: Often used in combination with other antihypertensive agents, especially useful in cases of hypokalemia. Hypokalemia, if other therapies are not available. The drug can also be used to prevent hypokalemia in patients with heart failure treated with digitalis, in cases where other treatment is not possible.

Entacron 25 is contraindicated in some of the following cases:
Severe liver dysfunction. Anuria, acute renal failure, severe chronic renal failure (glomerular filtration rate <10ml/min). Increase blood K+, decrease blood Na+. Hypersensitivity to spironolactone or to any of the other ingredients. Those who need to be cautious before taking the drug: Elderly, pregnant women, lactating women, children under 15 years old, people with liver failure, kidney failure, people with myasthenia gravis, hepatic coma , stomach ulcers .

Usage: The drug is prepared in the form of film-coated tablets and is taken orally. Patients should take the drug during the day, avoid taking it at night, because it can make it difficult for you to sleep and have to get up to urinate many times.
Dosage of the drug:
Adults:
Diuretic when there is treatment-resistant edema due to cirrhosis, nephrotic syndrome, congestive heart failure, especially if an increase in aldosterone is suspected, often used in combination with furosemide, thiazides or Similar diuretics: The initial dose is 25-200mg/day, divided into 2-4 times, used for at least 5 days, the maintenance dose is 75-400mg/day, divided into two divided doses. 2-4 times depending on the patient's response. Treatment of hypertension: The initial dose is 50-100 mg/day, divided into 2 to 4 times, for at least 2 weeks; Maintenance dose is individualized for each patient. However, currently this drug is rarely used to treat high blood pressure. Primary hyperaldosteronism: 100-400 mg/day, divided into 2-4 times before performing surgery to treat the cause of hyperaldosteronism. The lowest effective dose that can be used as long-term maintenance in patients who cannot have surgery. Children:
Diuretic effect or treatment of hypertension, ascites due to cirrhosis: The initial dose for patients is 1 to 3 mg/kg/day, used once or can be divided into 2-4 times. ; The dose is adjusted as appropriate as possible after 5 days.

Common side effects: Fatigue, headache, impotence, somnolence, increased prolactin production, breast enlargement in men, heavy milk flow, menstrual disorders, amenorrhea, postmenopausal bleeding, diarrhea , nausea Uncommon side effects: Erythema, rash, urticaria, hyponatremia, hyperkalemia, hyponatremia, cramps, muscle spasms, paresthesias, increased blood creatinine. Rare: Agranulocytosis, thrombocytopenia, anaphylactic reactions. When experiencing abnormal symptoms after taking the drug for a long time, the patient should immediately notify the doctor for the best advice and treatment.

This is a prescription drug that should be used under a doctor's prescription, the patient needs to tell the doctor about the history of allergies, other medical history when taking the drug. It can be used by pregnant and lactating women if they have heart failure, but the benefits and risks to the fetus need to be carefully weighed. In general, diuretic therapy is not generally recommended for pregnant women with common pregnancy-related edema. Like other diuretics, there is a risk of serious electrolyte disturbances. Therefore, if taking the drug for a long time, it is necessary to have regular electrolyte tests or to detect early signs of electrolyte imbalance such as vomiting, nausea, thirst, lethargy, restlessness, cramps, fatigue, rapid or slow changes in heart rate... Severe hyperkalemia may occur during treatment with Entacron 25, as with combined renal failure. Metabolic acidosis can also occur and is often associated with hyperkalemia, requiring special attention in patients with renal impairment. Drug interactions can occur when drugs are taken together. Note that this drug should not be used with antihypertensive drugs of the ACE inhibitor class, potassium supplements because this can cause hyperkalemia. Some anticoagulants such as coumarin, heparin are reduced when used concurrently with Entacron 25. Non-steroidal anti-inflammatory drugs reduce the effect of Entacron and should not be used concomitantly with lithium, because of the increased risk of lithium toxicity. Combinations of alcohol, sedatives, and drugs have addictive effects and increase the risk of severe orthostatic hypotension. The drug can increase the risk of side effects such as drowsiness, headache, so it should be used with caution when operating machinery. Entacron is a drug used in diseases such as kidney disease, liver disease, heart disease causing edema, ascites and also used in combination in hypertension. To ensure the effectiveness of treatment and avoid unwanted side effects, patients need to take the drug exactly as directed by the doctor, professional pharmacist.
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