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Spinolac fort belongs to the group of diuretics used to treat cholecystitis caused by liver edema, cardiac edema, renal edema, hypertension when other edema drugs are not effective.
1. What is Spinolac fort?
Spinolac fort has the main ingredients Spironolacton 50mg and Furosemid 40mg, which is indicated by doctors for use in the following cases:
Treatment of congestive heart failure. Reduce symptoms of edema caused by congestive heart failure and cirrhosis. Use in patients resistant to diuretics in monotherapy. Alternative to using spironolactone and furosemide separately at respective dose levels. Treatment of essential hypertension in patients with hyperaldosteronism.
2. Dosage and how to use Spinolac Fort
2.1. How to use Spinolac fort is in the form of tablets, used orally. For the drug to be most effective, patients should use it right after breakfast or lunch. The drug should not be used in the evening, especially at the beginning of treatment, because the drug affects the excretion of urine at night.
2.2. Dosage For adults
Diuretic when edema is resistant to treatment due to cirrhosis, congestive heart failure, nephrotic syndrome, especially suspected hyperaldosteronism, the dosage level is 1 - 4 tablets/day, taking 2 - 4 times, use at least 5 days, maintenance dose is 2-8 tablets/day, divided 2-4 times. Anti-hypertensive patients use 1-2 tablets/day, divided into 2-4 times, use at least 2 weeks, maintenance dose adjusted according to each patient. Patients with hyperaldosteronism use a dose of 2-8 tablets/day, divided into 2-4 times before surgery. Lowest effective dose that can be maintained for a long time in inoperable patients. For children
Diuretic or antihypertensive, ascites due to cirrhosis apply the initial dose of 1 - 3 mg/kg/day, administered once or divided into 2 - 4 times, the dose is adjusted after 5 day.
Note: The above dosage is for reference only, it depends on the condition and the progression of the disease. Therefore, patients need to consult a doctor or medical professional to get the right dose of medicine.
3. Overdose and how to handle Spinolac Fort
Manifestation: When a patient overdoses on the drug, he or she will experience some symptoms such as anxiety, shortness of breath, muscle weakness...
How to handle:
Usually the doctor will appoint gastric lavage in case severe reactions or use activated charcoal to reduce the toxicity of the drug. Have the patient check electrolyte balance and kidney function. Supportive treatment to reduce symptoms, specifically, if the patient has signs of hyperkalemia with changes in the electrocardiogram, they will give intravenous sodium bicarbonate, calcium gluconate; for patients to drink ion exchange resin (sodium polystyreb sulfonate - brand name Kayexalat...) to capture potassium ions, reduce blood potassium levels.
4. Precautions when using Spinolac Fort
During the use of Spinolac Fort, it should be noted:
Do not use the drug with patients who are allergic to the ingredients of the drug Do not use the drug with people with hyperkalemia, severe renal failure. Use with caution in patients with hypersensitivity to furosemide and to sulfonamide derivatives, such as antidiabetic sulphonamides. Use with caution in patients with anuria or renal failure caused by the use of drugs that are toxic to the kidneys or liver. The ingredients in the drug change the voice, so patients should watch for this reaction, especially those who have specific jobs that require a voice such as singers, actors or teachers. Pregnant women: Not to be used during pregnancy unless absolutely necessary. If using the drug, it is necessary to monitor the development of the fetus during the course of taking the drug. Lactation: Furosemide 40mg is an ingredient in the drug that can be excreted in breast milk and has the ability to inhibit lactation. Therefore, the drug should be used with caution in pregnant women.
5. Side effects when using Spinolac Fort
Some common reactions such as:
Causes systemic reactions: Headache, fatigue, impotence, somnolence. Endocrine reactions: Menstrual irregularities, increased prolactin, breast enlargement in men, excessive milk flow in lactating women, amenorrhea, bleeding after menopause. Gastrointestinal reactions: Diarrhea, nausea. Some rare reactions such as:
Skin related reactions: Erythema, rash, urticaria. Metabolism: Decreased serum sodium concentration, hyperkalemia. Nervous system: Paresthesia, muscle spasms. Genitourinary tract: Increased serum creatinine concentration. Some rare reactions:
Blood: Decreased platelet count, agranulocytosis.
6. Drug interactions
Possible drug interactions Spinolac Fort may occur as follows:
Using Spinolac fort with cardiac glycosides and diuretics, antihypertensive drugs may increase the possibility of causing hypotension. Using Spinolac fort with drugs that reduce potassium excretion, non-steroidal anti-inflammatory drugs, ACE inhibitors will cause a reaction to increase the concentration of potassium in the blood. Combining Spinolac fort with Sucralfate reduces the absorption of the drug from the gastrointestinal tract. Therefore, these 2 drugs need to be taken 2 hours apart. When Spinolac fort is used together with lithium, the drug may increase lithium plasma concentrations, increasing the risk of cardiotoxicity and neurotoxicity. Therefore, when using these two drugs together, it is necessary to monitor lithium levels regularly and adjust the dose when necessary. Concomitant use of antidiabetic drugs and amines that cause hypertension may decrease their effectiveness. Taking Spinolac fort with Cyclosporin increases the risk of Gout. Spinolac fort belongs to the group of diuretics used to treat cholecystitis caused by liver edema, cardiac edema, renal edema, and hypertension when other edema drugs have not been effective. To ensure the effectiveness of treatment and avoid unwanted side effects, patients need to strictly follow the instructions of the doctor, professional pharmacist.
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