Uses of Capflam

The main ingredient of Capflam is Diclofenac, which is a non-steroidal anti-inflammatory drug with strong anti-inflammatory, analgesic and antipyretic effects due to inhibition of Cyclooxygenase activity. Thereby reducing the formation of mediators of the inflammatory process such as Prostaglandin, Prostacyclin, Thromboxane.
Capflam is rapidly absorbed from the gastrointestinal tract after oral administration, the drug is absorbed faster when taken on an empty stomach. The drug is highly bound to plasma albumin, about 99%. Approximately 50% of an oral dose is metabolized by the liver in the first place, reaching maximum blood concentrations about 2 hours after oral administration.
The half-life of Capflam is about 1-2 hours, 60% of the drug is eliminated as metabolites with an active part, 1% as intact, the rest is excreted in the bile and feces.

Capflam is indicated in the following cases:
Pain relief in cases of acute pain such as in obstetrics and gynecology, maxillofacial pain, headache, pain due to trauma or surgery) and chronic pain. Chronic arthritis. Osteoarthritis Rheumatoid arthritis. Primary dysmenorrhea. Capflam is contraindicated in the following cases:
People who are allergic to Diclofenac, Aspirin or to other non-steroidal anti-inflammatory drugs. People with advanced stomach ulcers. Patient is taking Coumarin anticoagulant. Patients with asthma, bronchospasm, or cardiovascular disease. People with severe liver or kidney failure. Use caution when using Capflam in the following cases:
People with a history of ulcers, gastrointestinal bleeding. Patients with liver failure, kidney failure. Patients with cardiovascular disease, hypertension have fluid retention or edema. People with a history of blood clotting disorders, visual disturbances. Women who are planning to become pregnant should not take prostaglandin synthesis inhibitors such as Capflam because they inhibit embryo implantation. Use during pregnancy only when clearly needed. Capflam should not be used during the third trimester of pregnancy, as it inhibits uterine contractions and causes the ductus arteriosus to close prematurely. Diclofenac in Capflam is very small in breast milk, so it can be used by women who are breastfeeding. Capflam does not affect the ability to drive vehicles and use machines.

Capflam is used orally, it should be taken after eating. The dose of Capflam should be according to the doctor's prescription, the reference dose is as follows:
Adults: Use 1-2 tablets/time x 2-3 times/day. Children from 1 to 12 years old: Use 1 tablet/time, 2-3 times a day. Manifestations of an overdose of Capflam are similar to side effects but more severe. The treatment when drug overdose and experiencing side effects are:
Induce vomiting Gastric lavage Can give the patient activated charcoal to reduce drug absorption in the gastrointestinal tract and hepatobiliary cycle of the drug. Then treat the patient's symptoms and other necessary supportive measures.

While using Capflam, you may experience some side effects of the drug, including:
Headache Restlessness Tinnitus. Nausea, vomiting. Epigastric pain Diarrhea Indigestion Indigestion Anorexia. Increased liver transaminases. Irritation, gastrointestinal bleeding, and ulcer development. During the use of Capflam, if you see any unusual symptoms, you should immediately notify your doctor or go to the nearest medical facility for timely support from medical staff.

Using Capflam with anticoagulants increases the risk of bleeding. The use of the drug together with quinolone antibiotics will increase the CNS side effects of antibiotics. Using Capflam with Lithium and Digoxin will increase the blood levels of these drugs which can lead to poisoning. It is necessary to adjust the dose of Lithium, Digoxin when used with Capflam. Capflam will increase the toxicity of Methotrexate, Ticlopidine, Cyclosporin when used together with these drugs. Using Capflam with Aspirin, glucocorticoids will reduce the concentration of Diclofenac and increase the gastrointestinal damage caused by the drug. Co-administration of Capflam with antacids reduces the intestinal irritation of Diclofenac but will also decrease serum concentrations of the drug. Cimetidine helps to protect the duodenum from the harmful effects of Capflam. Using Capflam together with Probenecid will increase the concentration of Diclofenac thereby making it more effective, but toxicity can also occur, so the dose of Capflam should be reduced if necessary. Concomitant use of Diflunisal may increase blood levels of Diclofenac and decrease the clearance of Diclofenac, possibly causing very heavy gastrointestinal bleeding. Patients receiving antihypertensive drugs (eg, ACE inhibitors, beta-blockers, diuretics) should be closely monitored when co-administering Capflam.