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Asceniv is made in the form of an injection, with the main ingredient being immunoglobulins. The drug is used to strengthen the patient's immune system. So how should the drug be used?
1. Uses of Asceniv
What is Asceniv? Asceniv contains immunoglobulins made from the blood of healthy people with high levels of globulin (antibodies). Asceniv is an alternative therapy for people with primary immunodeficiency. The broad spectrum of neutralizing IgG antibodies can fight bacterial pathogens, viruses and their toxins, avoiding the risk of serious opportunistic infections.
Indications for the use of Asceniv:
Strengthening the body's natural immune system, reducing the risk of infection in people with immunodeficiency; Supplementation of platelets in patients with coagulopathy (eg, idiopathic thrombocytopenic purpura); Treatment of people with muscle weakness (multifocal motor neuropathy); Treatment of chronic polyneuropathy; Prevention of vascular disorders in people with Kawasaki syndrome. Contraindications to the use of Asceniv:
People who have had anaphylactic reactions or severe systemic reactions when using immunoglobulins; People with IgA deficiency have antibodies to IgA and have a history of hypersensitivity.
2. How to use and dose Asceniv
Usage: Subcutaneous injection or slow intravenous injection. During the injection process, medical staff will inject slowly, closely monitoring the patient's health. Normally, the infusion should be initiated at a rate of 0.5 mg/kg/min. If there are no side effects, Asceniv can be given more quickly. Patients should inform their doctor immediately if there are signs such as: flushing, chills, back pain, joint pain, muscle cramps, fever, nausea, vomiting, difficulty breathing,... Now, Asceniv injections should be stopped or given more slowly.
Dosage: As prescribed by the doctor based on the patient's medical condition, weight and response to the drug.
The recommended dose of Asceniv for replacement therapy in primary humoral immunodeficiency disease is 300-800 mg/kg body weight, administered every 3 to 4 weeks. Dosage may be adjusted over time to achieve desired trough concentrations and clinical response. Dosage adjustment of Asceniv may be necessary in patients who cannot maintain a total trough IgG trough level of at least 500 mg/dL with a target of 600 mg/dL. It is recommended to start with a 2nd infusion, titrate the dose proportionally, targeting a trough of 600 mg/dL or more, based on the previous trough and associated dose. Note: The vial should be checked before use. If there is coloration or precipitation, absolutely do not use the drug. Patients will need to use Asceniv regularly to ensure the highest treatment effect.
Overdose: When administering Asceniv intravenously, an overdose can lead to the risk of fluid overload and increased blood viscosity. Subjects most often at risk for this are elderly patients, people with heart failure or kidney failure.
3. Asceniv side effects
During the use of Asceniv, patients may experience some unwanted side effects such as:
Whole body: Flushing, fever, headache, dizziness, chills, back pain, bone and joint pain , muscle cramps, nausea or vomiting,... Patients should immediately notify their doctor or healthcare provider if any of these side effects or side effects persist or worsen; Injection site: At the injection site, swelling, pain and redness may occur. If this condition persists or causes discomfort, the patient should notify the doctor for appropriate treatment; Hypertension: Asceniv may cause an increase in blood pressure in patients. Therefore, patients should check their blood pressure regularly, notify the doctor immediately if the blood pressure is abnormally high; Serious side effects that require immediate medical attention: Bleeding, bruising, fainting, fast or irregular heartbeat, unusual tiredness; Infections: Asceniv may contain infectious agents because it is prepared from the blood of a normal person. Although the screening process takes place carefully, so the risk of infection is very low, but to ensure safety, doctors still need to talk to the patient about the possible risks. Patients should inform their doctor if there are any signs of infection such as jaundice, yellow eyes, persistent fever, sore throat, dark urine,...; Aseptic meningitis syndrome: Asceniv can cause aseptic meningitis syndrome hours to 2 days after injection. However, the risk of this condition is very low. Patients should tell their doctor right away if they have any of these warning signs: severe headache, drowsiness, stiff neck, high fever, eye pain, sensitivity to light, nausea, severe vomiting, etc. ..
4. Precautions when using Asceniv
Some notes that patients need to remember before and while using Asceniv include:
Before using Asceniv, patients should inform their doctor about a history of allergies to ingredients in the drug, preparations. other immunoglobulin or any allergic condition. Asceniv should be used with caution in people with the following conditions: Immune system problems (immunoglobulin A deficiency, monoclonal gammopathy), diabetes, high blood pressure, migraines, infections blood, dyslipidemia (hypertriglyceridemia), kidney disease, severe dehydration; There is a possible risk of blood clots during treatment with Asceniv. This condition is more common in the elderly, prolonged immobilization, coagulopathy, estrogen use, history of venous or arterial thrombosis, central vascular catheterization, increased blood viscosity, other risks. Asceniv can cause dizziness, so if the patient is dizzy, they should not drive, operate machinery or do jobs that require alertness. At the same time, the patient should not use other dizzying substances such as alcohol, stimulants; Do not use Asceniv for people with fructose and sucrose intolerance; There are insufficient data on the safety and efficacy of Asceniv in children under 12 years of age; Immunoglobulin products are often made from maltose sugar, so taking the drug can cause a person's blood sugar to rise falsely (despite the fact that blood sugar is still normal or low). Therefore, diabetics should consult a doctor before taking the drug, perform the necessary blood sugar tests; Patients should talk to their doctor about vaccinations. Asceniv may decrease the effectiveness of some vaccines made from live viruses (measles, chickenpox, mumps, rubella,...). Asceniv should be used with caution in the elderly because of the high risk of adverse events (especially renal); Women during pregnancy only take Asceniv when absolutely necessary, with the doctor's approval; Consult your doctor before taking Asceniv in a nursing woman.
5. Asceniv drug interactions
Some drug interactions of Asceniv include:
Drugs that can harm the kidneys, for example aminoglycoside antibiotics such as gentamicin; diuretics, eg furosemide; Asceniv may affect the results of certain tests (blood type tests, blood sugar). Therefore, the patient should inform the doctor and laboratory staff about the fact that they are using Asceniv. When using Asceniv, patients should strictly follow the doctor's instructions to ensure effective treatment. If there are any unusual symptoms while taking the drug, the patient should immediately notify the doctor for appropriate examination and treatment.
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