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Apuldon Suspension is a Dompamine receptor antagonist, indicated in the prevention and treatment of symptoms of vomiting and nausea. However, when using Apuldon, patients may experience some adverse reactions. Therefore, read the user manual carefully before use.
1. What is Apuldon Suspension?
Apuldon Suspension is a product of Aristopharma Ltd., which is prepared in the form of an oral suspension with the active ingredient Domperidon, concentration 5mg/5ml.
Domperidone has dopamine D1 and D2 receptor antagonist activity, similar to metoclopramide. Because the drug almost does not cross the blood-brain barrier, it has no effect on the mental and nervous system. Domperidone promotes gastric peristalsis (prokinetic agent), increases cardiac sphincter tone, and increases the amplitude of pyloric sphincter expansion after meals, but has no effect on gastric secretion. Domperidone is also capable of antagonizing the inhibition of prolactin secretion induced by dopamine or apomorphine, resulting in marked increases in plasma prolactin concentrations.
2. Indications of the drug Apuldon Suspension
Apuldon Suspension is indicated for the prevention and short-term treatment of severe nausea and vomiting caused by various causes such as:
Cancer chemotherapy or radiation therapy; Use levodopa/bromocriptine to treat Parkinson's disease. Or in combination with analgesics in the treatment of:
Nausea due to migraine; Digestive dysfunction; Indigestion not related to ulcer; Gastroesophageal reflux disease (GERD) ; Mild paralytic ileus in patients with diabetes mellitus; Acceleration of Bari movement in radiographic studies.
3. Contraindications of Apuldon Suspension
Do not use Apuldon Suspension in the following cases:
Patients with hypersensitivity to Domperidone or to any of its ingredients. Patients with cardiac conduction disorders or heart disease. Patients with moderate to severe hepatic impairment. Co-administration of Apuldon Suspension with drugs that prolong the QT interval or with strong inhibitors of CYP3A4 (eg, erythromycin, cimetidine, ketoconazole) because Apuldon is likely to increase the risk of prolongation of the QT interval on the electrocardiogram. Used in combination with antiemetics by inhibiting neurokinin-1 receptors in the brain. Patients with gastrointestinal bleeding, gastrointestinal perforation, or mechanical intestinal obstruction. The patient has a prolactin-secreting pituitary tumor (prolactinome). Pregnant women.
4. Dosage and usage of Apuldon Suspension
How to use: Patients take Apuldon Suspension 15 - 30 minutes before meals. The duration of symptomatic treatment of nausea and vomiting should not exceed 12 weeks.
Dosage:
Adults and children over 12 years old (weight over 35 kg): Take 10-20mg every 4-8 hours daily, maximum dose 80mg/day. Children 2 to 12 years of age (weighing less than 35 kg): 0.2 - 0.4 mg/kg body weight, orally every 4 to 8 hours. The lowest dose of Apuldon Suspension should be used for the shortest possible time. In the case of increasing the dose of domperidone to achieve a therapeutic effect, it is necessary to ensure that the benefits outweigh the risks.
5. Undesirable effects of Apuldon Suspension
When using Apuldon Suspension, patients may experience the following undesirable effects:
Uncommon side effects (with frequency 1/100 > ADR > 1/1000):
Digestive system: Dryness mouth, vomiting, nausea, diarrhea. Central Nervous System: Insomnia and headache Rare adverse effects (with ADR <1/1000):
Drowsiness and extrapyramidal disorders occur at a very low rate, usually due to mental disorders. permeability of the blood-brain barrier (premature infants, meningeal lesions) or from overdose. Increased serum prolactin can cause increased lactation, menstrual disorders, amenorrhea, breast enlargement or tenderness, decreased pleasure may be seen in patients receiving high doses of Apuldon Suspension for a long time. The risk of severe ventricular arrhythmias or sudden cardiovascular death is higher in patients taking daily doses above 30 mg and in patients over 60 years of age. Allergic reactions including urticaria, anaphylaxis, and Quincke's edema have been reported very rarely with the use of Apuldon Suspension.
6. Notes when using Apuldon Suspension
Use Apuldon Suspension with caution in high-risk patients such as:
Patients with prolonged cardiac impulse conduction time (especially prolonged QT interval). The patient has obvious electrolyte disturbances (hypokalemia and hypomagnesemia). Patients with cardiovascular disease (eg, congestive heart failure). Young children because of the risk of extrapyramidal syndrome. Apuldon Suspension is mainly metabolized by the liver. Therefore, Apuldon Suspension should not be used in patients with severe hepatic impairment. Patients with severe renal impairment (serum creatinine > 6 mg/dL) should consult their physician before taking the drug. Apuldon Suspension should not be used during pregnancy because there are no data on the safety of domperidone in this population. However, the drug has the potential to cause birth defects in animals. Apuldon Suspension should not be administered to a nursing woman because of the potential for maternal toxicity and small amounts of domperidone excreted in human milk (breast milk/plasma concentration ratio 0.03). Apuldon Suspension has no or negligible influence on the ability to drive and use machines. Overdose reactions of Apuldon Suspension, mainly seen in infants and children, include symptoms such as agitation, convulsions, somnolence, altered consciousness, disorientation, and extrapyramidal reactions. In this case, activated charcoal can be used and the patient closely monitored, supportive treatment, control extrapyramidal symptoms with anticholinergics, antiparkinsonian drugs. There is no specific antidote for Apuldon.
7. Drug interactions
Apuldon Suspension has interactions with the following drugs:
Anticholinergics and opioid analgesics: These drugs may antagonize the effect of Apuldon Suspension on gastrointestinal motility. Drugs that inhibit hepatic CYP3A4 enzymes (eg, ketoconazole and other antifungal azoles, erythromycin, clarithromycin, amiodarone, amprenavir, atazanavir, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir, diltiazem, verapamil): metabolism of domperidone, which increases the risk of QT prolongation and the risk of arrhythmias. Therefore, these drugs should be avoided with Apuldon Suspension. Bromocriptin: Domperidone may antagonize the plasma prolactin-lowering effects of bromocriptin. Paracetamol : Apuldon Suspension may increase the rate of gastrointestinal absorption of paracetamol by altering gastrointestinal motility. Antacids and Antacids: Reduced bioavailability of Apuldon Suspension. Therefore, Apuldon Suspension should not be taken with antacids or taken before meals and antacids after meals. Dopamine agonists: Apuldon Suspension blocks the peripheral effects of these drugs.
8. Preservation of drugs
Store Apuldon Suspension in sealed packaging, in a cool, dry place, at a temperature below 300C, protected from light. Apuldon oral suspension should only be used within 3 months of opening the vial. Above is all information about Apuldon Suspension, patients need to carefully read the instructions for use, consult a doctor / pharmacist before use. Absolutely do not arbitrarily buy Apuldon Suspension to treat at home because there may be unwanted side effects.
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