What is Travicol 650 used for?

Travicol 650 is indicated when the patient has a headache, sore throat, teeth, pain due to cold or flu, fever after vaccination. Read the following article to know what Travicol is and how to use it effectively.

Travicol has the main ingredient is Paracetamol belonging to the group of antipyretic and pain relievers, packaged in the form of 650mg tablets. The drug is indicated for the symptomatic treatment of pain in the following cases: Headache, joint pain, toothache, earache, muscle pain, sore throat, pain due to trauma.
Fever symptoms caused by bacterial infections, flu, colds or vaccinations.
Pharmacodynamic properties of Travicol 650:
The mechanism of action of the analgesic is not yet fully determined. Paracetamol's mode of action is primarily by inhibiting the synthesis of prostaglandins in the central nervous system (CNS) but to a lesser extent, through its peripheral action by blocking the generation of pain impulses. Peripheral effects other than prostaglandin synthesis inhibitors may also be due to other substances that increase the sensitivity of pain receptors to chemical or mechanical stimuli. Paracetamol's antipyretic action is by targeting the hypothalamus, specifically the thermoregulatory center, to induce vasodilation in the periphery, thereby increasing blood flow through the skin, causing sweating and heat loss. . The effect at the thermoregulatory center may also be related to the inhibition of prostaglandin synthesis in the hypothalamus. Pharmacokinetic properties of Travicol 650:
Absorption: Travicol 650 is readily absorbed directly from the gastrointestinal tract with peak plasma concentrations occurring approximately 30 minutes to 2 hours after oral administration. The effects of Travicol 650 last for an average of 4 to 6 hours after administration. Metabolism: The drug is metabolised in the liver and excreted mainly in the urine as sulfate and glucuronide conjugates. Elimination: Paracetamol is excreted less than 5% unchanged. The half-life of the drug varies from 1 to 4 hours. At normal therapeutic concentrations, the binding of the drug to plasma proteins is negligible but increases with increasing concentration.

Travicol 650 should not be used in the following cases:
Avoid using Travicol 650 if you are allergic to any of its ingredients. Get medical attention immediately if you notice any symptoms such as skin rash, swelling and/or itching, dizziness, trouble breathing... after taking this medicine. Analgesic Nephropathy is a condition that causes kidney damage due to long-term use of pain relievers. Using Travicol 650 is not recommended if you have kidney problems related to overuse of pain relievers. Travicol 650 is converted to the active form in the liver. This medicine is not recommended if you have severe liver problems. The patient is often anemic or has heart or lung disease. Patients with glucose-6-phosphate dehydrogenase deficiency. Paracetamol 650 MG Tablet is not recommended for children under 10 years of age. Precautions for use:
Pregnancy: Travicol 650 can be used during pregnancy for the shortest possible duration and the lowest effective dose. However, you should use this medicine after consulting your doctor. Breast-feeding: Travicol 650 is considered safe during breast-feeding. It passes into breast milk in very small amounts and is unlikely to harm your baby. However, you should use this medicine after consulting your doctor.

How to take Travicol 650:
The medicine must be swallowed whole, do not try to crush, break or mix in water. Travicol 650 mg is taken orally 1 hour before a meal. Dosage of Travicol 650:
Adults: Take 1 tablet each time, 2 to 3 times a day. Do not use more than 6 tablets/day. Travicol 650 mg should not be used for self-administration of pain for more than 10 days in adults and more than 5 days in children. Do not use Travicol 650 mg for self-treatment of high fever > 39.5oC, fever lasting more than 3 days, as it may be a sign of a medical condition that needs to be diagnosed quickly. Please read the user manual carefully before use.
Note: The above dosage is for reference only. The specific dose depends on the condition and the progression of the disease. To get the right dose, you need to consult your doctor or healthcare professional.

Common side effects of Travicol 650:
Nausea and vomiting; Stomachache; Diarrhea ; Undigested; Skin rash. Rare side effects when using Travicol 650
Bloody or black, tarry stools; Bloody or cloudy urine; Fever sometimes accompanied by chills; Pain in the lower back and/or side (severe and/or sharp); severe skin rash or itching; Sores, sores, or white spots on the lips or in the mouth; Sudden decrease in urine output; Unusual bleeding or bruising; unusual tiredness or weakness; Yellow eyes or skin. Excessive single or repeated overdose of Travicol 650 (eg, approximately 8 to 10 g per day, for 1 to 2 days) or long-term analgesic use can cause hepatotoxicity, which may cause symptoms. symptoms such as: Nausea, vomiting, abdominal pain, skin - mucous membranes and nails blue-violet.
Treatment of overdose:
Active supportive treatment: Gastric lavage in all cases, preferably within 4 hours after ingestion. The main mechanism of detoxification therapy is the administration of more effective sulfhydryl compounds less than 10 hours after ingestion of Paracetamol or Methionine. Also can use salt bleach or activated charcoal, these drugs have the ability to reduce the liver's ability to absorb Paracetamol. If things get worse, call 911 immediately or go to the nearest local medical center.

Interactions with alcohol:
You should avoid drinking alcohol while taking this medicine. Symptoms such as fever, chills, rash, joint pain and swelling, extreme weakness, nausea should be reported to a doctor immediately; Drinking too much alcohol can increase the risk of liver toxicity from Paracetamol, including rare cases such as fatal hepatitis, severe liver failure requiring a liver transplant. The proposed mechanism is induction of liver microsomal enzymes during chronic alcohol use, which may lead to a faster metabolism of paracetamol and increased production of potentially hepatotoxic metabolites. Interactions with laboratory testing:
Urine test 5-HIAA; You may get a false positive result for this test if you take Paracetamol. Drug Interactions:
Paracetamol and Leflunomide may increase the risk of liver damage Paracetamol and Lomitapide taken together cause hepatotoxicity. Lomitapide may cause elevation of serum transaminases and hepatic steatosis. Cholestyramine: Causes the absorption of Paracetamol to be reduced. Domperidone and Metoclopramide: Metoclopramide and Domperidone increase the absorption of Paracetamol. However, if necessary, it is not necessary to avoid concurrent use. Warfarin : When regular and prolonged use of Paracetamol with Warfarin and other Coumarins, the anticoagulant effect of the drug may be enhanced, increasing the risk of bleeding; but in occasional doses there is no significant effect. Chloramphenicol: Co-administration with Paracetamol increases the plasma concentration of Chloramphenicol. Anticonvulsants (Phenytoin, Barbiturates, Carbamazepine...) induce liver enzymes that increase the metabolism of Paracetamol into toxic substances for the liver. Concomitant use with Isoniazid may increase the hepatotoxicity of Paracetamol. In addition, Barbiturates, Carbamazepine, Hydantoins, Sulfinpyrazone can increase the hepatotoxic potential of Paracetamol Disease Interactions:
Patients with liver disease should use some other safer alternative medicine. Interactions with food:
May slow down the absorption of extended-release preparations slightly; The rate of absorption may be reduced with foods high in carbohydrates. The above are the uses and notes to use when using Travicol 650. This is a drug to be used under the prescription of a doctor, you should not use it on your own. Any drug can have adverse effects on the body, so use it only when needed.