Uses of Sulpragi

Sulpragi is classified as a psychotropic drug, used to treat anxiety in the elderly and chronic schizophrenia. The following article will introduce the uses, usage and notes when using Sulpragi for patients.

1. What is Sulpragi?

Sulpragi belongs to the group of psychotropic drugs used in the treatment of anxiety and acute and chronic schizophrenia. The drug is prepared in the form of capsules, with the main ingredient being Sulpiride with a content of 50mg/tablet.

2. What is the use of Sulpragi?

Sulpragi drug with the main active ingredient is Sulpiride, which is classified as a psychotropic drug, has antipsychotic, antidepressant effects, selectively inhibits the neuronal dopamine receptors D2, D3 and D4. It can be seen that the Supiride in Sulpragi is like a combination drug between sedative and antidepressant. Sulpragi has advantages over classic antipsychotics such as Phenothiazine or Butyrophenon. According to clinical studies, Sulpiride in Sulpragi, when used in high doses, controls the positive symptoms of schizophrenia, helping patients to have a more stable mood. With low doses of Sulpragi will work to make people with lethargic schizophrenia become more alert and active.
Sulpragi is relatively slowly absorbed from the gastrointestinal tract because of its low bioavailability depending on the individual. Peak Sulpragi concentrations are reached 3 to 6 hours after dosing. Sulpragi distributes fairly rapidly into tissues. The plasma protein binding capacity of Sulpragi is quite low (less than 40%), and is excreted in the urine and faeces about 95% as unchanged drug.

3. Indications for taking Sulpragi

Sulpragi is used in the treatment of anxiety symptoms in the elderly. Treatment of severe behavioral disorders (agitation, self-harm) in children over 6 years of age, children with autism. Treatment of patients with acute and chronic schizophrenia.

4. Contraindications to taking Sulpragi

In the following cases, the use of Sulpragi is contraindicated:
Patients with hypersensitivity to Sulpiride or to any component of Sulpragi. The patient has an adrenal myeloma. Sulpragi should not be used in cases of acute porphyria. The patient fell into a depressed CNS state, coma, alcohol poisoning and neuroleptic drugs. Patients with prolactin-dependent tumors (eg, breast cancer, pituitary tumor).

5. Dosage and usage of Sulpragi

Sulpragi tablets in the form of capsules are indicated for oral administration with the following doses:
Basic dosage for short-term treatment of anxiety in adults: 50-150mg/day, the patient can be divided into several oral doses. , maximum oral dose 4 times Dosage for behavioral disorders children over 6 years old: 5-10mg/kg/day. Dosage of Sulpragi for acute and chronic schizophrenia: Adults: Negative symptoms in patients with schizophrenia: Initially, 200-400mg/time, twice a day, if necessary, the dose can be increased until the evening. maximum 800mg/day. Positive symptoms of schizophrenia: 400mg/time, twice a day. Gradually increase the dose to a maximum of 1200mg / time, 2 times a day. Combined positive and negative symptoms in patients with schizophrenia: 400-600mg/time, twice a day. Children: Children over 14 years old: Take a dose of 3-5mg/kg/day. Children under 14 years old: Contraindicated. Elderly people: The initial dose is 50-100mg/time, take 2 times a day and start increasing the dose until effective. In patients with renal failure, the dose depends on the creatinine clearance: Creatinine clearance from 30 to 60ml/min: Use a dose equal to 2/3 of the dose of Sulpragi for normal people. Creatinine clearance from 10-30ml/min: Use a dose equal to 1/2 dose of Sulpagri drug for normal people. Clearance less than 10ml/min: Use a dose equal to 1/3 of the normal dose of Sulpagri. However, patients with moderate to severe renal impairment should not take Sulpiride.

5. Sulpragi side effects

Common side effects in patients taking Sulpragi are as follows
Common side effects:
Insomnia; Increased prolactin blood, increased lactation; Menstrual disorders, possibly amenorrhea; Extrapyramidal syndrome, the patient can sit still, have a crooked neck due to spasms, or have a habit of turning eyes; Parkinson's Syndrome. Rare side effects:
Gynecomastia in men; Malignant high fever syndrome; Orthostatic hypotension, bradycardia, arrhythmia; Hypothermia, photosensitivity, sun sensitivity; Cholestatic jaundice.

6. Notes when using Sulpragi

Sulpragi should be used with caution in patients with renal impairment, dose reduction and regular monitoring of creatinine clearance are required. If the patient has severe renal impairment, consider intermittent therapy. It is necessary to strengthen monitoring when treating with Sulpragi in the following subjects: Epilepsy patients, elderly patients prone to orthostatic hypotension. When there is a high fever of unknown cause, it is necessary to stop taking Sulpragi immediately to avoid causing the malignant neuroleptic syndrome. For people with mania and hypomania, taking Sulpragi may worsen symptoms. In elderly patients with dementia, Sulpragi is likely to increase mortality. Sulpragi may increase the risk of venous thrombosis in patients. In pregnant and lactating mothers, Sulpragi is distributed into breast milk in relatively large amounts, which may cause adverse reactions in the nursing infant. Therefore, the use of Sulpragi should be avoided in pregnant and lactating women. Sulpragi may cause drowsiness, so it is not recommended to drive a vehicle or operate machinery. Sulpragi is a psychotropic medication used to treat anxiety in adults and people with symptoms of schizophrenia. The drug is used as prescribed by the doctor and must be closely monitored after taking the drug.

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