Uses of Agimol 80mg

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1. What are the effects of Agimol 80mg?

Agimol 80 ingredients in each 1g pack contains Paracetamol 80 mg in the form of granules mixed with oral suspension.
1.1. Pharmacodynamics of Agimol 80mg Paracetamol is a non-steroidal antipyretic analgesic. Paracetamol (also known as Acetaminophen or N - acetyl - p - aminophenol) is the active metabolite of Phenacetin. This is an effective pain reliever and fever reducer that can replace aspirin. However, unlike aspirin, paracetamol is not effective in treating inflammation. In equal doses in grams, Paracetamol has analgesic and antipyretic effects similar to that of Aspirin. Paracetamol with therapeutic doses has little impact on the cardiovascular and respiratory systems, does not change the acid-base balance, does not cause irritation, scratches or stomach bleeding like when using preparations containing salicylates. The reason is that Paracetamol has no effect on systemic Cyclooxygenase, but only affects Cyclooxygenase/Prostaglandin of the central nervous system. Paracetamol has no effect on platelets or bleeding time. 1.2. Pharmacokinetics of the drug Agimol 80mg Absorption: Agimol 80 is rapidly and almost completely absorbed from the gastrointestinal tract. Peak plasma concentrations are reached within 30 to 60 minutes after a therapeutic dose of Agimol 80. Distribution: Agimol 80 is rapidly and uniformly distributed into most body tissues. Approximately 25% of paracetamol in the blood is bound to plasma proteins. Metabolism ability: Agimol 80 is metabolized in cytochrome P450 in the liver to form N - acetyl benzoquinonimin as an intermediate, which continues to conjugate with the Sulfydryl group of Glutathion to produce inactive substances. Elimination ability: Agimol 80 is mainly excreted in the urine as metabolites, with a clearance of 19.3 l/h. The half-life is about 2.5 hours on average. When Agimol 80 is used in high doses (>10 g/day), it will generate a lot of N - acetyl benzoquinonomin that depletes liver glutathione, then N - acetyl benzoquinonimin will react with the sulfydride group of liver proteins causing liver damage, liver necrosis, which can be life-threatening if not treated promptly. 1.3. Effects of Agimol 80 Drug Agimol 80 reduces body temperature in febrile individuals, but rarely in normal subjects. Agimol 80 acts on the hypothalamus causing hypothermia, increased heat release due to vasodilation and increased peripheral blood flow.

2. Indications of Agimol 80mg

Treatment of fever, nasal congestion, runny nose, runny nose, rhinitis, exudative mucous membrane inflammation. Treatment of sinusitis, aches and pains such as headaches, muscle and joint pain caused by colds or allergies to the weather.

3. Usage and dosage of Agimol 80mg

How to use Agimol 80mg:
Agimol 80 is usually taken orally. For patients unable to swallow, a rectal suppository may be used; however, the rectal dose required for the same plasma concentrations may be higher than the oral dose. Agimol 80 should not be used for self-administration of pain for more than 10 days in adults or more than 5 days in children, unless directed by a doctor, because such severe and persistent pain could be a sign of a serious illness. medical conditions that should be diagnosed and treated under supervision by a physician. Dosage of the drug Agimol 80 for adults
The regulations on therapeutic doses of the drug are usually guided for adults according to oral administration. Therapeutic doses with other routes of administration are specified in the leaflet. Do not arbitrarily change the therapeutic dose of the drug without consulting the treating doctor or pharmacist.
Dosage of Agimol 80 for children
Children from 1 to 3 months old: Take 1⁄2 sachets/time, repeat after 8 hours if needed. Children from 4 to 11 months old: Take 1 sachet/time, repeat after 4-6 hours if needed. To minimize the risk of overdose, children should not be given more than 5 doses of Paracetamol for pain relief or fever reduction within 24 hours, unless directed and directed by the treating physician.

4. Undesirable effects of the drug Agimol 80mg

Common side effects when using Agimol 80
Serious skin reactions such as Stevens - Johnson syndrome, Lyell's syndrome, toxic epidermal necrolysis, acute generalized pustulosis, although rare, but possible life-threatening risk. If a skin rash or other skin manifestations occurs, the patient should stop using the drug and consult a doctor. Skin rashes and other allergic reactions such as erythema and urticaria may occur, but are sometimes more severe and may be accompanied by drug fever and mucosal lesions. In rare cases, the active ingredient Paracetamol has caused neutropenia, thrombocytopenia and pancytopenia. Uncommon side effects, 1/1 000 < ADR < 1/100:
Gastrointestinal: feeling of nausea, vomiting. Hematology: hematopoietic disorders, neutropenia, pancytopenia, leukopenia or anemia. Kidney: kidney disease, nephrotoxicity when long-term abuse treatment. Rare adverse effects, ADR < 1/1 000:
Skin: toxic epidermal necrolysis, Stevens - Johnson syndrome, Lyell syndrome, acute generalized exanthematous pustulosis. Other possible adverse effects: hypersensitivity reactions. Usually, side effects or unwanted effects (Adverse Drug Reaction (ADR), unwanted effects will go away after stopping use of the drug. If you experience rare side effects that are not mentioned in the leaflet, please inform your treating doctor or healthcare professional immediately.

5. Drug interactions of Agimol 80mg

Drug interactions with other drugs are often quite complicated due to the influence of many ingredients in the drug. Studies or recommendations have shown common interactions with use. Some possible drug interactions are as follows:
Long-term intake of high doses of Agimol 80 slightly increases the anticoagulant effect of coumarin and indandion derivatives. Attention should be paid to the potential for severe hypothermia in patients concomitantly receiving Agimol 80 with phenothiazines and antipyretic therapy. Anticonvulsants such as Phenytoin, Barbiturates, Carbamazepine induce enzymes in the liver microsomes, which can increase the hepatotoxicity of paracetamol by increasing the metabolism of the drug into substances that are toxic to the liver. Drinking too much alcohol over a long period of time can increase the risk of liver toxicity. At the same time, agents can change the ability of the ingredients in the drug to work. Therefore, you need to consider taking the drug with alcohol, tobacco, alcoholic or fermented beverages.

6. Some notes after taking Agimol 80mg

Contraindications of Agimol 80:
The drug is contraindicated in patients with hypersensitivity to one of the components of Agimol 80. People who are deficient in the enzyme glucose - 6 - phosphate dehydrogenase. Patients with severe liver failure, narrow-angle glaucoma, acute asthma, prostatic hypertrophy, bladder neck obstruction, peptic ulcer, pyloroduodenal obstruction, taking MAO inhibitors for 14 years day. Breastfeeding women, infants and premature infants. People who need to be careful before using Agimol 80: elderly people, pregnant women, lactating women, children under 15 years old, people with liver failure, kidney failure, people with hypersensitivity or allergies with any ingredient of the drug... or subjects with myasthenia gravis, hepatic coma, stomach ulcers.
Other notes when using Agimol 80:
For people with phenylketonuria and those who have to limit the amount of phenylalanine put into the body, they should avoid using drugs containing Paracetamol with drugs or foods containing Aspartame. . For some people with hypersensitivity, specifically asthma, treatment with Agimol 80 should be avoided with sulfite-containing drugs or foods. Should be used with caution in patients with pre-existing anemia, impaired liver and kidney function. Drinking alcoholic beverages such as alcohol can increase the hepatotoxicity of paracetamol, so avoid or limit alcohol consumption. People with rare hereditary problems of galactose intolerance, the lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine. For medicines containing Paracetamol: Your doctor will warn you about signs of a serious skin reaction such as Stevens-Johnson syndrome (SJS) or Lyell's syndrome, toxic epidermal necrolysis (TEN) or acute generalized exanthematous pustulosis (AGEP). Precautions during pregnancy: When you are pregnant, you need to consider and consult your doctor or pharmacist before taking this medicine. Even tested drugs still have risks when used. Note the breastfeeding period: Mothers need to carefully weigh the benefits and risks for mother and baby. Do not arbitrarily use the drug without carefully reading the instructions for use and instructions of the treating doctor to ensure the safety of mother and baby. Agimol medicine 80mg is an effective medicine for colds, fever, runny nose and stuffy nose. In addition, Agimol 80 is also used in the treatment of sinusitis, rhinitis, aches and pains such as headaches, muscle and joint pain caused by flu or allergies to the weather.
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