Mixed phase bipolar affective disorder

Bipolar disorder is a type of mental disorder that causes fluctuations in emotions, activity levels, and daily activities. Symptoms of bipolar disorder f31 vary from stage to stage, in particular, mixed-phase bipolar disorder has many unusually severe manifestations.

1.1 Episodes of Bipolar Disorder According to the ICD-10 system, bipolar disorder falls under category F31 (also known as bipolar affective disorder f31 ) with many different stages and degrees of illness, consists of:

1.2 What is mixed-phase bipolar disorder? This is an unstable mood disorder characterized by severe and mild symptoms occurring at the same time or alternating within the same episode, meaning that a person can be in both a manic episode and a manic episode. , and depression.
Of most forms of bipolar affective disorder f31, this is the severe form where the mood is constantly fluctuating, difficult to control.

The identification of mixed-phase bipolar disorder is relatively clear: a mixed episode is defined when manic and depressive manifestations occur simultaneously, or in alternating sequence but at a rapid rate. fast change.
Some specific manifestations are:
The patient is in an irritable or excessively agitated mood. Signs of depression are similar to those of regular depression, including sad moods, loss of interest, feelings of worthlessness, guilt, and suicidal thoughts. This phase of juxtaposition of contrasting moods can last anywhere from a few days to a few weeks or even months if left untreated. This episode can also recur many times, after which the patient recovers much more slowly than in pure manic/depressive episodes.

The most serious risk of this unstable mood disorder is suicide. People with f31 bipolar affective disorder in general are 10 to 20 times more likely to commit suicide than the general population, of which about 10% - 15% of people with this syndrome lose their lives because of the disorder. Suicide.
There is a growing body of evidence that mixed episode bipolar disorder has many unusual and conflicting features, putting patients at greater risk of suicide than other episodes of bipolar disorder. .
At the same time, statistics show that people with bipolar disorder are also at higher risk of substance abuse: nearly 60% of patients with bipolar disorder abuse drugs or alcohol. This makes the symptoms of bipolar disorder more intense, severe, and difficult to control.
3.1 Who is at risk for mixed-phase bipolar disorder? Almost anyone can develop bipolar affective disorder. Mixed episodes are common in about 50% of people with bipolar disorder. These people are often at a young age, especially in adolescence, rarely after the age of 50. In addition, people with a family history of bipolar f31 affect also have an increased risk of developing this condition. disease is higher.
3.2 Treatment of mixed bipolar affective disorder Manic or depressive episodes of mixed episode both require drug treatment, however, are more difficult to control a lot of. Treatment drugs also need to have a combination of both mood stabilizers and antipsychotics.
Mood Stabilization While lithium is considered the standard treatment for manic manifestations, it is less effective when mania and depression are co-occurring during an episode of unstable mood swings. Therefore, at this stage, if lithium is used, it may take several weeks for the full effect to take place. This makes maintenance treatment better than an acute manic episode.
Besides, some other drugs are also applied are:
valproic acid: antiepileptic drug with mood-calming effects in people with bipolar disorder, proven to be more effective than lithium when treating seizures mania in mixed disorder. Carbamazepine, lamotrigine are also effective mood stabilizers. Antipsychotics Several atypical antipsychotics are effective FDA-approved treatments for manic episodes in mixed bipolar affective disorder, including:
Aripiprazole (Abilify). Asenapine (Saphris). Olanzapine (Zyprexa). Quetiapine (Seroquel). Risperidone (Risperdal). Ziprasidone (Geodon). Sometimes, antipsychotic drugs need to be combined with mood stabilizers for prophylaxis.

Some common antidepressants such as fluoxetine, paroxetine, sertraline... have aggravated manic symptoms, but did not improve depression when both occur simultaneously. As a result, most experts advise NOT to use antidepressants during episodes of mixed-phase f31 bipolar disorder.
Instead, mood stabilizers and atypical antipsychotics are considered first-line treatments for this episode.
It can be seen that mixed phase bipolar disorder is a complex and contradictory emotional state when two completely opposite states take place at the same time. This makes treatment more complex, requiring attention and follow-up from psychiatrists.
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