Are high GGT and Cyfra readings dangerous?

Question
I go for regular health check-ups, blood test results: Gamma GT: 86.0 U/L; Cyfra : 4.15 ; What do the results mean?
Phan Huu Thien (1962)
Reply
Hello, please answer your 2 test results as follows: GGT enzyme (Gamma Glutamyl transferase) is usually present in the liver and also in the kidneys, spleen, and pancreas. , small intestine. GGT is one of the enzymes that play an important role in the diagnosis of cholestasis in the liver. GGT is more valuable than other enzymes because it is very sensitive to changes in cholestasis. GGT activity is increased in several pathological conditions of the liver, such as chronic hepatitis, alcoholic liver injury, viral hepatitis, and metastatic liver cancer. Besides, the GGT test also plays an important role in determining the cause of increased ALP. Typically, both ALP and GGT are elevated in bile duct disease and liver disease. Only ALP is increased in bone diseases. Therefore, when ALP is increased in individuals with normal GGT levels, the increase in ALP is largely due to bone disease.
The average person has a GGT in the range < 60UI/L. However, the index is different for different sexes, namely:
Male < 55 U/L Female < 38 U/L Levels of increase in GGT:
GGT increased 1-2 times: mild. GGT increased 2 - 5 times: moderate level. GGT increased more than 5 times: severe. Causes of elevated liver enzymes
Patients have a habit of using alcohol for a long time. An unscientific diet makes the liver work hard such as eating a lot of fat, greasy food, eating less fiber and fruits. Overworked, prolonged stress. Having liver diseases such as hepatitis A, B, C, D, E Patients with cirrhosis have liver tumors. Abuse of stimulants. Have diabetes. Pancreatitis disease. Fatty liver disease . Heart failure disease. His GGT result of 86 UL/l is a bit high and mild. If you drink alcohol, you should be very limited, in addition, you can go to the hospital for a comprehensive examination to do more tests such as ALT, AST, Bilirubin, Albumin, HBsAg or abdominal ultrasound ...
The Cyfra test was mentioned in your question, but this is probably Cyfra 21-1: CYFRA 21-1 is a marker that can be used to diagnose, evaluate treatment effectiveness, and monitor cancer prognosis. lung cancer, especially non-small cell lung cancer and also used in combination with some other markers in other cancers such as esophageal, breast, pancreatic, cervical and bladder cancers .
Normal value: 95% of normal healthy individuals have a serum CYFRA 21-1 level < 2.0 μg/L.
In benign lung diseases such as chronic obstructive pulmonary disease, pneumonia, pulmonary tuberculosis, chronic bronchitis, bronchial asthma, pneumothorax, and benign lung tumors, serum CYFRA 21-1 levels are common. < 3.3 μg/L.
In benign pelvic diseases such as endometritis, ovarian cysts, adnexitis, benign ovarian tumors, urinary tract infections, renal cysts, benign bladder tumors, CYFRA level 21-1 serum is usually <3.1 μg/L.
In benign gastrointestinal diseases: in acute and chronic hepatitis, pancreatitis, cholangitis, gastritis , ileitis, colitis, colon polyps, blood CYFRA level 21-1 bar is usually < 3.0 μg/L.
In renal failure: serum CYFRA 21-1 level < 3.0 μg/L, rarely exceeds this level.
Your result if it is true Cyfra 21-1 is slightly above the normal value. You should go to the hospital for a comprehensive examination, repeat CYFRA 21-1 and combine other markers related to lung cancer such as NSE, CEA, Pro GRP, CA125, SCC as well as X-ray, X-ray. CT ... to rule out lung cancer.
Doctor Le Duy Cuong - Laboratory Department - Vinmec Times City International General Hospital