Krabbe disease is a relatively rare condition. Diagnosis is usually based on blood tests or skin biopsy. Treatment of Krabbe disease is primarily aimed at relieving symptoms and improving quality of life.

Sickle cell disease (SCD) is a group of inherited disorders that affect hemoglobin, a molecule in red blood cells that carries oxygen throughout the body. People with this disorder have atypical hemoglobin molecules called hemoglobin S, which can distort red blood cells into a sickle, or sickle, shape.