Scleroderma is divided into two main types. One is localized scleroderma, which affects only the skin. The other is systemic sclerosis, which affects the skin, tissues, blood vessels, and internal organs, such as the digestive tract, heart, lungs, or kidneys.

Parry-Romberg syndrome, also known as progressive facial atrophy, is a rare condition characterized by progressive shrinkage and degeneration (progressive atrophy) of the tissues beneath the skin. This usually affects only one side of the face, but it can sometimes affect other parts of the body.