Barraquer-Simons syndrome is the name given to a rare disorder that has important and often overlooked clinical consequences. Barraquer-Simons syndrome is an acquired form of focal lipodystrophy of unknown cause, characterized by loss of subcutaneous fat confined to the upper body. Insulin resistance and other metabolic complications are less common compared to other forms of lipodystrophy.

Inherited metabolic disorders are metabolic disorders that are determined by genes. Most people with inherited metabolic disorders carry genes that cause deficiencies in certain enzymes. There are hundreds of types of inherited metabolic disorders, each with its own unique symptoms, treatment, and prognosis.

Metabolic syndrome is a group of factors that increase the risk of heart disease and diabetes. When these factors are combined, the risk increases even more.