Heart failure and severe heart failure is a complex clinical syndrome that results from physical damage or dysfunction of the heart leading to an inability of the ventricles to receive blood (diastolic heart failure). or ejection (systolic heart failure). Currently, medicine has many solutions to treat heart failure patients, including patients with severe heart failure. Digoxin drug to treat heart failure has been interested in recent times. The following article will provide some precautions when using Digoxin to treat severe heart failure.