Cholestatic liver disease can cause many dangerous complications that need to be treated properly to prevent serious complications that affect health and can even be life-threatening.

The interaction between bile acids and the gut microbiota is implicated in the pathophysiology of many intestinal and gastrointestinal diseases, especially cholestatic liver disease. In particular, the progression of autoimmune cholestatic liver diseases also affects the composition of the gut microbiota, exacerbating the development of cholestasis in this interactive cycle.