Almost all specialists agree that antibiotics should only be used when absolutely necessary and, if possible, the amount of antibiotics taken should be limited. However, in clinical practice, it is not always the case that using just one antibiotic will eliminate the infection. Sometimes, a combination of two or three different antibiotics is needed to effectively treat the condition. Antibiotic combination therapy is necessary in certain clinical situations

Each antibiotic will have an effect on a site in the composition or a step in the biological reactions of the bacterial cell. Therefore, it can be said that the antibiotic is bacteriostatic because it can stop the growth and growth of bacterial cells. However, in some cases, it is necessary to combine antibiotics to improve the effectiveness of treatment.