This is an automatically translated article.
The article is professionally consulted by Master, Doctor Nguyen Thi Hong On - Department of Obstetrics and Gynecology - Vinmec Phu Quoc International General Hospital.Ovarian failure is one of the leading causes of infertility. In fact, there are many patients who are found to have ovarian failure when they go to the fertility clinic.
1. What is the diagnosis of early ovarian failure based on?
Early ovarian failure diagnosis should be based on the following criteria:Women under 40 years old. There is an increased concentration of FSH > 30 - 40 IU/L, this limit depends on each laboratory. Women with irregular menstrual cycles will have signs of decreased fertility and when FSH measurement on day 3 of the menstrual cycle is > 10 - 15 IU/L and serum estradiol concentration at the same time ≥ ≥ 80pg/L.
2. Tests for premature ovarian failure
FSH and estradiol levels should be tested on day 3 of the menstrual cycle to diagnose premature ovarian failure.2.1. FSH Level Test FSH is a hormone released from the anterior pituitary gland in the brain. In women, the hormone FSH stimulates oocyte development, which is part of the monthly menstrual cycle.
For women under 40 years of age, an increase in FSH level on day 3 of the menstrual cycle > 30-40 IU/L will be diagnosed as premature ovarian failure. Why are high hormone levels a sign of ovarian failure?
In a normal woman, when measuring FSH on the 3rd day of the menstrual cycle will range from 4.7 to 21.5 IU/L. As women enter perimenopause, FSH levels will begin to tend to increase. The reason is that during this stage, a woman's ovaries become less responsive to the gonadotropic hormones FSH and LH. After menopause begins, FSH levels will always rise to 30 IU/L or more.
Xét nghiệm FSH - xét nghiệm suy buồng trứng
2.2 Estradiol Test Estradiol is a form of the hormone estrogen it is produced by the ovaries, breasts, and adrenal glands. During the menstrual cycle, FSH stimulates the growth of immature ovarian follicles. When the follicle begins to develop, the oocyte releases estradiol, which in turn acts on the hypothalamus and pituitary gland to increase the release of the hormones GnRH and LH to promote ovulation.
Xét nghiệm Estradiol - xét nghiệm suy buồng trứng
2.3. Chromosome testing In addition to the FSH and Estradiol tests, your doctor may order a chromosomal test to diagnose the cause of premature ovarian failure. Because some women have premature ovarian failure due to having only one X chromosome instead of two, or having another defective chromosome.
Tests to do to diagnose early ovarian failure are FSH and estradiol hormone tests. Specifically, FSH hormone will be abnormally high above 30 IU/L and estradiol hormone will decrease lower than normal. In addition, the patient may be given additional chromosomal testing to diagnose the cause of the disease.
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