This is an automatically translated article.
The article is written by Master, Doctor Tran Quynh Trang - Doctor of Biochemistry - Laboratory Department - Vinmec Times City International Hospital.
Estradiol is a major female sex hormone, secreted mainly in the ovaries and plays an important role in the development and maintenance of the female reproductive system. So what is the change in Estradiol in IVF?
1. What is Estradiol?
Estradiol (E2) is a female sex hormone that is directly involved in reproduction and the menstrual cycle in females. This hormone is produced specifically in ovarian follicles, but is also produced in other tissues such as testes, adrenal glands, liver, fat, brain and breast. Estradiol is synthesized in the body from cholesterol through a series of reactions and the intermediates then produce estradiol.
Estradiol đóng vai trò quan trọng đối với chức năng sinh sản của phụ nữ
2. What is IVF?
IVF (Invitro fertilization) is an assisted reproductive technology in which sperm fertilize an ovum in an implanted disc (conventional invitro-fertilization) or by intracytoplasmic sperm injection (ICSI). ).The success of IVF depends on age, the success rate is 47.4% for women under 35 years old; 30.1% for women 38-40 years old; 20.3% in women aged 41-42 years and 10.7% in women aged 43-44 years.
The primary concern in the in vitro fertilization (IVF) cycle is obtaining a sufficient number of mature oocytes, good embryo quality and ultimately successful conception. Prediction of successful IVF outcomes has been focused on clinical research for many years. Previous studies suggested a role for different hormones such as follicle-stimulating hormone FSH, estradiol, inhibin A and inhibin B.
Thụ tinh ống nghiệm giúp hỗ trợ sinh sản cho các cặp vợ chồng vô sinh hiếm muộn
3. What is the change in Estradiol in IVF?
The role of estradiol (E2) in the IVF cycle is well known up to the insemination stage. The majority of estradiol is produced from the granulosa cells of the ovary. In addition, there is a gradual metabolism of Estradiol from Testosterone, estradiol is also produced in a small part from the adrenal cortex, the brain.
3.1 For women
Estradiol levels in women will change with the menstrual cycle, specifically in the follicular phase, Estradiol levels are at 11.3 - 232.3 pg/ml, when ovulating this concentration will increase to 41.1 - 397.4 pg/ml In the luteal phase, estradiol gradually decreases to 22.3 - 340.3 pg/ml, in menopause, the estradiol concentration drops to less than 5 - 137.4 pg/ml.
On the day of HCG activation, due to an increased number of follicles, high estradiol levels lead to low endometrial receptivity and thus reduced pregnancy rates in IVF cycles.
According to a study by Shdha Prasad, Yogesh Kumar et al., when studying Estradiol levels on day 5 and day of activation to predict the potential for IVF success when using a long regimen, it shows:
Success of pregnancy during IVF depends on endometrial receptivity, which is related to embryo quality and implantability. It has been well established that a certain amount of Estradiol is required per follicle in order to get pregnant. The study therefore explored the efficacy of estradiol as a marker for clinical pregnancy. Serum estradiol is used to monitor controlled ovarian hyperstimulation. Both low (<500 pg/ml) and high (>4000 pg/ml) serum estradiol concentrations, on the day of hCG administration, lead to an unavoidably low and high oocyte yield, thereby reducing viability. their fertility. Increased or decreased estradiol levels can impair cytoplasmic maturation and decrease the probability of pregnancy. The likelihood of pregnancy during an IVF cycle is maximum when the peak estradiol concentration at the time of hCG administration is between 900 and 1,900 pg/ml. Controlled ovarian stimulation during IVF is usually monitored by serum estradiol levels.
Nồng độ Estradiol đạt 900 đến 1.900 pg/ml báo hiệu khả năng mang thai trong chu kỳ IVF
3.2 For men
Estradiol also plays an important role in male sexual function, especially when testosterone levels are low.Estradiol in men is required to regulate libido, erectile function and spermatogenesis. Estrogen receptors, as well as aromatase, the enzyme that converts testosterone to estrogen, are abundant in the brain, penis, and testicles, organs important for sexual function. However, this test is usually only followed up in women, especially during IVF.
Khách hàng có thể đến Trung tâm Hỗ trợ sinh sản Vinmec để được thăm khám, điều trị
Reproductive Support Center - Vinmec International General Hospital is one of the leading centers in Vietnam, built and applied a treatment process that combines comprehensive examination, combining both gynecology and obstetrics. to provide the optimal method for each patient's case.
Advantages when customers choose Vinmec fertility center:
Equipped with modern equipment, clean air system according to international standards to ensure lab quality, single cabinet system to optimize quality embryo, improving the success rate for each cycle of artificial insemination. Implement most advanced assisted reproductive techniques in the world: ICSI (injection of sperm into the oocyte cytoplasm); support embryo escape membrane; Reproductive reserve: embryo freezing, sperm freezing, oocyte freezing to help customers take the initiative in giving birth at will, transferring embryos on day 5, minimizing pregnancy; male infertility techniques (PESA, MESA, TEFNA, TESE) Besides advanced reproductive support methods, a team of excellent doctors in the country and the world, with prestige and long-term experience in the field of infertility .
Please dial HOTLINE for more information or register for an appointment HERE. Download MyVinmec app to make appointments faster and to manage your bookings easily.
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