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Pariet 10mg drug is manufactured by Eisai Co., Ltd - JAPAN. Pariet 10mg has the main ingredient is rabeprazole sodium, used in the treatment of peptic ulcers.
1. What is Pariet 10mg?
Pariet 10mg is a prescription drug, classified as an antacid, anti-reflux and anti-ulcer drug. Pariet's active ingredient is rabeprazole sodium.
Dosage form: enteric film-coated tablets, yellow. Each tablet contains 10mg of rabeprazole sodium and excipients just enough. Packing form: box of 1 blister of 14 tablets.
2. Uses of Pariet 10mg
Pharmacodynamics: rabeprazole sodium is classified as an antacid, has no anticholinergic or H2 antihistamine effects. However, it is possible to inhibit gastric acid release through inhibition of the H+/K+ -ATPase channel.
After oral administration of a 20 mg dose of rabeprazole sodium, the anti-acid effect occurs after 1 hour, reaching a maximum after 2-4 hours. After 23 h, baseline inhibition of acid secretion was 69% and inhibition of food-induced acid secretion was 82%. This effect lasts 48 hours and increases slightly with repeated daily dosing. Acid secretion will return to normal after 2-3 days of discontinuation of the drug.
In patients participating in drug studies using therapeutic doses of 10 - 20 mg/day for 43 months, gastrin levels gradually increased over 2-8 weeks, which represents an effective inhibitor of acid secretion and stability when continue treatment. After 1 to 2 weeks of discontinuation of the drug, gastrin levels returned to pre-treatment levels.
Pharmacokinetics:
Absorption: Pariet 10mg is prepared in the form of enteric-soluble tablets, insoluble in the stomach. This is necessary, since rabeprazole is unstable in acidic media. Therefore, absorption of rabeprazole occurs after the drug has passed through the stomach. Pariet 10 mg is rapidly absorbed, peaking in plasma 3.5 hours after a 20 mg dose. The bioavailability of Pariet 10mg is not affected by food. Distribution: High plasma protein binding, about 97%. Metabolism: rabeprazole sodium is metabolised in the liver via the cytochrome P450 system to two metabolites, the cytochrome P450 conjugated form and the carboxylic acid form, and two other metabolites that have not been well studied. Elimination: rabeprazole sodium is excreted mainly in the urine (90%).
3. Indications and contraindications of Pariet 10mg
Pariet 10mg drug is indicated in the following cases:
Active duodenal ulcer Active benign gastric ulcer Anastomotic ulcer Gastroesophageal reflux moderate to very severe Zollinger-Ellison syndrome, other cases of hypersecretion H.pylori eradication in patients with peptic ulcer disease (in combination with other antibiotics) Who should not take Pariet 10mg? (Contraindications)
Patients with hypersensitivity to any of the ingredients in Pariet 10mg.
4. Dosage and how to use Pariet 10mg
Pariet 10mg is a prescription drug, so you can only take it with a doctor's prescription. Do not arbitrarily change the dose and use of the drug, do not give the medicine to others when they see that they have the same symptoms as you.
Dosage:
Adults:
Active duodenal ulcer, benign gastric ulcer, oral ulcer: 10mg/time/day, taken in the morning. Typically, patients with active duodenal ulcer heal after 4 weeks, benign gastric ulcer heal after 6 weeks. However, some cases require an additional 4-6 weeks of treatment. Gastroesophageal reflux - ulcerative / erosive form: 10mg / time / day x 4 - 8 weeks. Gastroesophageal reflux disease - moderate to very severe: 10mg / time / day x 4 weeks. If after 4 weeks there is no clinical improvement, the patient should be examined and evaluated further. Zollinger-Ellison syndrome, other cases of hypersecretion: initial dose is 60mg/day, then increase to 60mg/time x 2 times/day or 100mg/time/day. Eradicating H.pylori: 10mg/time x 2 times/day, combined with 500mg clarithromycin x 2 times/day and 1g amoxicillin x 2 times/day. Note: There is no need to adjust the dose of Pariet 10mg in patients with liver and kidney failure.
How to use: The patient needs to drink the whole tablet with filtered water, do not chew or crush the tablet, because it will affect the absorption of the drug. Pariet 10mg should be taken in the morning to facilitate adherence.
What to do if you miss a dose of Pariet 10mg?
Take another dose as soon as you remember. If it is almost time for your next dose, skip it and take your next dose as scheduled. Do not take a double dose to make up for the missed dose. What to do when taking an overdose of Pariet 10mg?
There are very few reports of documented overdoses. Symptoms of overdose are minimal and reversible without medical intervention. Currently, there is no specific antidote to rabeprazole. Treatment of rabeprazole overdose consists of symptomatic treatment and improvement of condition.
5. Undesirable effects when using Pariet 10mg
During the use of Pariet 10mg, you may encounter unwanted effects such as:
Common: infection, insomnia, dizziness, headache, cough, sore throat, rhinitis, digestive disorders, nausea, vomiting, back pain. Uncommon: agitation, drowsiness, bronchitis, sinusitis, dry mouth, belching, dyspepsia, erythema, myalgia, cramps, fracture, arthralgia, urinary tract infection, elevated liver enzymes. Rare: leukopenia, leukocytosis, thrombocytopenia, allergies, anorexia, hypomagnesaemia, depression, gastritis, taste disturbances, stomatitis, jaundice, hepatitis, hepatic encephalopathy, pruritus, blistering, sweating, interstitial nephritis, weight gain. Very rare: Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme. Frequency not known: confusion, peripheral edema, hyponatremia, gynecomastia in men. The undesirable effects mentioned above are not exhaustive. In addition, you may experience other unusual symptoms while taking Pariet 10mg. Please contact your doctor or pharmacist immediately for advice and timely treatment.
6. Drug interactions
Pariet 10mg drug has a strong and long-lasting inhibitory effect on gastric acid secretion, so interactions with drugs with pH-dependent absorption may occur. Concomitant administration of Pariet 10mg with ketoconazole or itraconazole reduces blood concentrations of the antifungal drug. Therefore, monitoring and dosage adjustments should be made when these drugs are co-administered.
Co-administration of atazanavir/ritonavir with omeprazole or atazanavir with lansoprazole reduces atazanavir concentrations. Although the combination with Pariet 10mg has not been studied, similar results are expected for other proton pump inhibitors. Therefore, the concomitant use of Pariet 10mg with atazanavir is not recommended.
7. Some notes when using Pariet 10mg
Pregnant women: There are insufficient data on the safety and toxicity of Pariet 10mg in pregnancy. Therefore, use Pariet in pregnant women only when the potential benefit to the mother outweighs the risk to the fetus.
Lactation: There are insufficient data to confirm whether rabeprazole is excreted in human milk. However, animal studies have shown that rabeprazole is excreted in rat milk. Therefore, Pariet 10mg should not be used in nursing women. If use is mandatory, breast-feeding should be discontinued.
People working at height, driving and operating machines: rabeprazole does not impair the ability to drive or use machines. However, drowsiness reduces concentration and alertness, so it is necessary to avoid driving or operating complex machinery, working at height.
Other notes:
Gastrointestinal malignancies should be excluded before initiating treatment with Pariet 10mg, as clinical improvement does not exclude the presence of gastric cancer. manage. Patients on long-term treatment, especially more than 1 year, should be checked regularly. Do not use Pariet 10mg for children under 12 years old, because there is no experience for the use of this drug in this population. There are insufficient data on the use of Pariet 10 mg in patients with severe hepatic dysfunction. Therefore, caution should be exercised when initiating treatment in this population.
8. Preservation of drugs
Store Pariet 10mg in sealed packaging, in a cool, dry place, away from direct sunlight, below 30 degrees Celsius. Keep this medicine out of reach of children and pets. Do not leave the medicine at home. Places that are too hot or too humid will affect the quality of the medicine. Pariet 10mg has the main ingredient is rabeprazole sodium, used in the treatment of peptic ulcers. This is a prescription drug, so patients should strictly follow the instructions of the doctor, professional pharmacist.
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