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Mergenza is a drug used for patients with breast cancer. Currently, the use of drugs in treatment needs to be strictly followed to achieve the best effect. So how should Margetuximab-cmkb be used?
1. What is Margetuximab-cmkb?
Margetuximab-cmkb is a monoclonal antibody that targets HER-2/neu-positive breast cancer cells. HER2 is overexpressed in some breast cancers. HER2 receptors on cells send signals to the cell to grow and divide. HER2-overexpressing cancers have too many receptors, which causes cells to grow and divide faster by inhibiting HER2.
2. Uses of Margetuximab-cmkb
Monoclonal antibodies will be made in the laboratory. They are used to attach to targets found on specific types of cancer cells. These antibodies can work in different ways. These include stimulating the immune system to destroy cells, helping to stop cell growth or other functions necessary for cell growth. Margetuximab is thought to block these receptors, preventing them from triggering cell growth.
3. How to take Margetuximab-cmkb (Mergenza)
Margetuximab-cmkb is given intravenously. The length of your infusion will depend on your treatment plan and whether you can tolerate the medication. The dosage is based on your body size and type of cancer. The frequency of dosing and adjuvant chemotherapy depends on the treatment regimen. Margetuximab-cmkb is usually indicated in combination with chemotherapy. As Margetuximab-cmkb is indicated only for the treatment of HER2-positive cancers. Before starting treatment, a sample of the tumor will be tested in a laboratory to determine if it is HER2 positive.
4. Possible side effects of Margetuximab-cmkb (Mergenza)
There are some possible side effects while taking Margetuximab-cmkb such as:
4.1 Heart problems Margetuximab-cmkb can cause heart problems or worsen heart problems pre-existing heart failure, including congestive heart failure. Your heart function will be checked using an echocardiogram or MUGA scan before starting treatment with margetuximab-cmkb, and every few months during and after treatment is completed. Tell your doctor if you experience sudden weight gain or swelling in your ankles or legs. If cardiac function declines, Margetuximab-cmkb is stopped. The risk of heart problems is higher when Margetuximab-cmkb is used in combination with anthracycline chemotherapy drugs.
4.2 Infusion-related side effects Some patients experience chills and fever within 24 hours of the first infusion. The first infusion of Margetuximab-cmkb may also cause nausea/vomiting, pain at the tumor site, headache, dizziness, and rash. For these reactions, the infusion will be stopped, acetaminophen or diphenhydramine given to reduce the reaction, and restarted at a slower rate when symptoms have resolved. This usually does not happen with subsequent infusions.
Some more serious reactions are possible but very rare. Symptoms of a serious reaction include difficulty breathing, wheezing, low blood pressure, and increased heart rate. The infusion will be stopped if this happens and your doctor will determine if it is safe to start the infusion again. Notify your nurse immediately if you develop any relevant symptoms.
4.3 Hepatotoxicity This drug can cause liver toxicity, which your doctor can monitor using blood tests called liver function tests. Tell your doctor or healthcare provider if you notice yellow skin or eyes, dark or brown urine, or pain in your abdomen. This could be a sign of liver toxicity.
4.4 Fatigue Fatigue is very common during cancer treatment and is a feeling of exhaustion that often does not subside with rest. During cancer treatment and for some time afterward, you may need to adjust your schedule to manage fatigue. Plan time to rest during the day and save energy for more important activities. Exercise can help fight fatigue; A simple daily walk with a friend can be helpful.
4.5 Anemia Red blood cells are responsible for carrying oxygen to the tissues in the body. When your red blood cell count is low, you may feel tired or weak. Tell your doctor if you feel short of breath or have chest pain. If the count is too low, you may receive a blood transfusion.
4.6 Nausea or vomiting Doctors can prescribe medication to help control nausea and vomiting. In addition, dietary changes may be helpful. Avoid things that can worsen symptoms, such as heavy or greasy/fatty foods, spices, or acids (lemons, tomatoes, oranges). Try salt water or ginger ale to ease symptoms.
4.7 Kidney problems This drug may cause kidney problems, including increased creatinine levels. Your doctor can monitor using blood tests. Notify your doctor if you notice decreased urine output, blood in your urine, swollen ankles, or loss of appetite.
4.8 Diarrhea Your doctor will prescribe you some medicine to relieve diarrhea. Also, try eating low-fiber foods such as steamed rice and boiled or grilled chicken. Avoid raw fruits, vegetables, whole grain breads, cereals and seeds. Soluble fiber is found in some foods and absorbs fluids, which can help relieve diarrhea. Foods rich in soluble fiber include apple sauce, bananas (ripe), canned fruit, orange portion, boiled potatoes, white rice, white flour products, oatmeal, rice cream, rice cream noodles and farina. Drink 8-10 glasses of non-alcoholic, caffeine-free water each day to prevent dehydration.
4.9 Reproductive concerns Exposing an unborn baby to this drug may cause birth defects. Therefore, you should not become pregnant or become a father while taking this medicine. Effective birth control is needed during treatment and for at least 4 months after treatment. Even if your period stops or you believe you are not producing sperm, you may still be able to conceive and conceive. You should consult your doctor before breast-feeding while taking this medicine.
Above is important information about Margetuximab-cmkb (Mergenza). Knowing the instructions, usage, and dosage will help the treatment process be more effective and safe.
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