How to read Pepsinogen test results?

Question
Hello doctor,
Yesterday, I had a Pepsinogen test, the result of Pepsinogen I was 57.03ng/mL, Pepsinogen II was 10.11 ng/mL. The Pepsinogen I/II ratio was 5.64 ng/mL. So the doctor asked me how to read Pepsinogen test results? Thank you doctor.
Dang Phuong Thao (1988)
Answer
Answered by Master, Doctor Do Thi Hoang Ha - Doctor of Biochemistry - Laboratory Department, Vinmec Hai Phong International General Hospital.
Hi,
With the question “How to read Pepsinogen test results? ", the doctor would like to answer as follows:
Gastric cancer (or gastric adenocarcinoma) is the fourth most common cancer and the second leading cause of cancer death. The majority of gastric cancers originate in the mucosa, and cancers with different sites of onset may present with different symptoms and course, resulting in different treatment and prognosis. The early diagnosis of gastric cancer has actually increased the cure rate and reduced the mortality rate significantly. Testing for Pepsinogen I, II serum and PGI/II ratio can help do that.
Pepsinogen (PG) is a proenzyme (proenzyme) of pepsin - a proteolytic enzyme - secreted by the mucosal cells of the stomach. Pepsinogen I is synthesized by the principal cells of the mucosa in the basal region of the stomach, while PG II is synthesized by the mucosal cells of all the cardia, basal, antrum, and duodenum regions. colon.
The normal value of serum Pepsinogen I level in normal healthy subjects is widely used in many countries around the world is greater than 70 ng/mL, for Pepsinogen II is 7.5 ng/mL and of PGI/II ratio is greater than 3. Pepsinogen I level, Pepsinogen II and PGI/II ratio do not differ by age and sex.
In patients with atrophic gastritis, the serum Pepsinogen I level decreased significantly while the serum Pepsinogen II level remained virtually unchanged. Thus, a high probability based on the significance of the Pepsinogen test is that you may have atrophic gastritis (as PGII levels and PGI/II ratios remain within the normal range, thus giving little indication of the possibility. cancer). For a more accurate diagnosis, you can book an appointment with a gastroenterologist for instructions on examining and performing further in-depth tests.
If you still have questions about reading Pepsinogen test results, you can go to a hospital of Vinmec Health System for further examination and advice. Thank you for trusting and sending questions to Vinmec. Wishing you lots of health.
Best regards!